A5068751681- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- Infective Endocarditis Diagnosis and Management
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Hepatitis C virus research
- Infectious Diseases and Tuberculosis
- Vitamin D Research Studies
- HIV Research and Treatment
- HIV/AIDS Impact and Responses
- Mycobacterium research and diagnosis
- Hernia repair and management
- HIV, Drug Use, Sexual Risk
- Kawasaki Disease and Coronary Complications
- Antibiotic Use and Resistance
- Immunotherapy and Immune Responses
- HIV/AIDS Research and Interventions
- Coenzyme Q10 studies and effects
- Sarcoidosis and Beryllium Toxicity Research
- Antimicrobial Resistance in Staphylococcus
- Global Maternal and Child Health
- Healthcare Systems and Reforms
Kunming University of Science and Technology
2021-2023
Yunnan University
2023
Aga Khan University
2012-2021
Aga Khan University Hospital
2012-2017
Northern Lincolnshire and Goole Hospitals NHS Foundation Trust
2007
Broomfield Hospital
2005
Vitamin D enhances host protective immune responses to Mycobacterium tuberculosis by suppressing Interferon-gamma (IFN-g) and reducing disease associated inflammation in the host. The objectives of this study were determine whether vitamin supplementation patients with (TB) could influence recovery.Two hundred fifty nine pulmonary TB randomized receive either 600,000 IU Intramuscular D3 or placebo for 2 doses. Assessments performed at 4, 8 12 weeks. Early secreted T cell activated 6 kDa...
Hepatitis B virus (HBV) infection is a global public health problem that closely related to liver cirrhosis and hepatocellular carcinoma (HCC). The prevalence of acute chronic HBV infection, cirrhosis, HCC has significantly decreased as result the introduction universal vaccination programs. first hepatitis vaccine approved was developed by purifying surface antigen (HBsAg) from plasma asymptomatic HBsAg carriers. Subsequently, recombinant DNA technology led development vaccine. Although...
Background Crimean Congo Hemorrhagic Fever (CCHF) is a life threatening acute viral infection that presents significant risk of nosocomial transmission to healthcare workers. Aim Evaluation CCHF prevention and control (IP&C) practices in facilities routinely manage cases Eurasia. Methods A cross-sectional IP&C survey was designed distributed centers 10 endemic Eurasian countries 2016. Results Twenty-three responses were received from Turkey, Pakistan, Russia, Georgia, Kosovo, Bulgaria, Oman,...
Abstract Crimean–Congo hemorrhagic fever (CCHF) is endemic in the Baluchistan province, Pakistan. Sporadic outbreaks of CCHF occur throughout year especially individuals contact with infected livestock. Nosocomial transmission remains a risk due to difficulties diagnosis and limited availability facilities for isolation suspected patients. Rapid virus infection required early management disease prevent transmission. This study describes case 43‐year‐old surgeon who contracted during surgical...
Granulomas caused by Mycobacterium Tuberculosis have been observed at autopsy in the heart, pre-dominantly myocardium and endocardium, but rarely involving coronary vessels valvular structures. tuberculosis endocarditis is extremely rare, with most reports coming from series. We report case of a 17 year old immunocompetent girl who presented history fever, malaise, foot gangrene left sided hemiparesis. On investigation she was found to infective aortic, mitral tricuspid valves. She had...
More than 250 million people worldwide have chronic hepatitis B virus (HBV) infections, resulting in over 1 annual fatalities because HBV cannot be adequately treated with current antivirals. Hepatocellular carcinoma (HCC) risk is elevated the presence of HBV. Novel and powerful medications that specifically target persistent viral components are needed to remove infection. This study aimed use HepG2.2.15 cells rAAV-HBV1.3 C57BL/6 mouse model established our laboratory examine effects 16F16...
Abstract Introduction Invasive aspergillosis is a serious complication in immunocompromised patients. It an opportunistic disease, which predominantly occurs the lungs, although dissemination to virtually any organ possible. immunocompetent patient with extension mediastinum has rarely been reported. Here, we present case of no apparent immunodeficiency state, who presented Aspergillus endocarditis and fulminant invasive extensive involvement mediastinal structures, ultimately was...
Serum levels of the inflammatory C-X-C motif chemokine 10 (CXCL10) are raised in tuberculosis (TB). CXCL10 gene expression is downregulated monocytes by metabolically active vitamin D3 (1,25dihydroxy D). Stratification patients serum 25hydroxyvitamin D (25[OH]D) at baseline showed that treatment-induced decrease occurred those with 'insufficient' and 'deficient' but not 'optimal' levels. In deficient group, 25(OH)D an inverse correlation may thus be a useful biomarker for follow-up response...
In Pakistan, HIV has converted from outbreak to concentrated epidemic and also bridged into the low-risk population. The in Pakistan mainly comprises subtype A. Here, we present first case genetic analysis of a circulating recombinant form 56_cpx Pakistani HIV-infected patient. Genetic sequence indicated that had more drug resistance mutation than other sequences available database.
After the first case of HIV infection in 1987, number cases has continuously increased Pakistan, turning from isolated incidents to outbreaks concentrated epidemic. The epidemic Pakistan is mainly driven by subtype A; however, overlapping transmission chains facilitate recombination between subtypes and existing circulating recombinants forms (CRFs), leading emergence unique recombinant (URFs). In this study, we report a URF (URF_DG) Pakistani HIV-infected patient. Phylogenetic drug...
Introduction: A recent meta-analysis by the World Health Organization estimated that rate of central-line associated blood stream infections (CLABSIs) among adult ICU patients in developing countries was 12.2 per 1000 central line days which is 2-3 fold higher than developed countries, and account for a crude unadjusted excess mortality 15% to 24%. This burden not only unacceptably high, but most part remains unaddressed. Excellent evidence exists CLABSI reduction, like bundled initiative...
Purpose To analyse the implementation of fast‐tracking pathway hip fractures from accident and emergency to orthopaedic wards. Design/methodology/approach A retrospective audit analysing 100 case notes fast‐tracked selected at random for period one year was undertaken. Findings Several deficiencies were identified in pathway. Practical implications Recommendations have been made correction inadequacies identified. Originality/value This paper aims increase efficiency safety system fractures,...
Background: Dengue infection, which cause dengue fever (DF), haemorrhagic (DHF) and shock syndrome (DSS) are currently endemic or intermittently epidemic in many tropical sub-tropical regions of the world. According to World Health Organization, has recently become a major public health concern globally. It is generally found regions, more specifically urban semi-urban areas. Objectives: This study was conducted find out relationship with climate factors such as temperature, humidity...
Background: Rationalizing the use of antibiotics which are considered last resort against organisms resistant to first line agents has remained top priority antibiotic stewardship programs in healthcare institutions. The problem is particularly important developing countries where more discrepancies have been reported and range available antimicrobials for also quite narrow. We conducted this study our hospital a 550 bed tertiary care, ISO certified, JCIA accredited teaching Pakistan....
Background: Dengue has recently become a major public health concern globally. It is generally found in tropical and sub-tropical regions, more specifically urban semi-urban areas. This study was designed to find out relationship of dengue infection with climatic factors such as rainfall, temperature relative humidity the warm humid region Karachi, Pakistan. conducted fever climate temperature, rainfall during period 2009–2017. Methods materials: The confirmed infections hospital cases were...
Objective: This study describes a case of disseminated phaeohyphomycotic lymphadenitis in young female with delayed diagnosis and good clinical response after appropriate treatment. Methods: A 32-year-old presented erythematous to violaceous papules oozing discharge bilaterally her inguinal region for few months. History revealed tuberculous meningitis 4 years earlier treated first line anti-tuberculous therapy 18 months, 2 previously she developed pigmented discharging lymph nodes axillae....