A5065575529- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Advanced Glycation End Products research
- Neuroscience and Neuropharmacology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- S100 Proteins and Annexins
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- Immune cells in cancer
- High Altitude and Hypoxia
- Pharmacological Effects of Natural Compounds
- Acute Ischemic Stroke Management
- Neurological Complications and Syndromes
- Neurological Disorders and Treatments
- Diabetes and associated disorders
- CAR-T cell therapy research
- Heme Oxygenase-1 and Carbon Monoxide
- Migraine and Headache Studies
- Cancer Immunotherapy and Biomarkers
- RNA regulation and disease
- Cancer, Hypoxia, and Metabolism
- Muscle metabolism and nutrition
- Fatty Acid Research and Health
- Neonatal and Maternal Infections
- Neuroblastoma Research and Treatments
Nanchang University
2020-2024
Hong Kong Polytechnic University
2023-2024
First Affiliated Hospital of Jiangxi Medical College
2024
First Affiliated Hospital of Nanchang University
2020-2023
Zhongda Hospital Southeast University
2017-2021
Southeast University
2018-2020
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder predominantly affecting the elderly population. It characterized by cognitive deficits associated with accumulation of amyloid-beta plaques and neurofibrillary tangles. Huang-Lian-Jie-Du (HLJD) decoction, recognized as representative formulation heat-clearing detoxification effects, has been demonstrated to be effective in treating AD. However, underlying mechanisms require further investigation. Methods...
Hippocampal dysfunction related to cognitive impairment and emotional disorders in young children adolescents caused by neonatal hypoxic-ischemic brain injury (HIBI) has attracted increasing attention recent years. Crosstalk between the nervous immune systems organized hypoxia-ischemia (HI) insult may contribute hippocampal after HIBI. Extracellular HMGB1 functions as a damage-associated molecular pattern instigate amplify inflammatory responses, but whether this molecule is correlated with...
Background and Objective . Chronic unexpected mild stress (CUMS) destroys synaptic plasticity of hippocampal regenerated neurons that may be involved in the occurrence poststroke depression. Astrocytes uptake glutamate at synapse provide metabolic support for neighboring neurons. Currently, we aim to investigate whether CUMS inhibits formation through a transporter, GLT-1, astrocytes ischemic stroke rats. Method We exposed rats ceftriaxone, during intervention period determine effects GLT-1...
Muscle wasting and diminished physical performance contribute to the morbidity mortality of chronic kidney disease (CKD), for which no curative therapy exists. Accumulating evidence indicates that impaired angiogenesis occurs in muscles CKD models. Therefore, proangiogenesis is considered a potentially effective strategy limiting CKD-associated myopathy. Hypoxia-inducible factor (HIF)-prolyl hydroxylase inhibitor (HIF-PHI) stabilizes HIF enhances muscle during acute ischemia; however, little...
Background. Ketamine has been shown to possess lasting antidepressant properties. However, studies of the mechanisms involved in its effects on poststroke depression are nonexistent. Methods. To investigate these mechanisms, Sprague-Dawley rats were treated with a single local dose ketamine after middle cerebral artery occlusion and chronic unpredicted mild stress. The hippocampal dentate gyrus analyzed through assessment N-methyl-D-aspartate receptor/calcium/calmodulin-dependent protein...
Little is known about the effect of astroglial GLT-1 post-stroke depression (PSD) rat model on function neural stem cells (NSCs). This study aimed to investigate whether PSD rats affect differentiation NSCs from neonatal hippocampus and synaptic formation NSC-derived neurons. Astrocytes were isolated left normal adult SD rats. A lentiviral vector was used silence expression in astrocytes respectively co-cultured with (control), PSD, silenced for 7 days. GLT-1, GFAP, MAP2, Synaptophysin...
OBJECTIVE: To investigate whether the HMGB1 DAMP signaling pathway is involved inresveratrol anti-oxygen glucose deprivation (OGD)-induced microglialinflammatory processes and explore its underlying mechanisms.