A5112293636- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Cancer, Hypoxia, and Metabolism
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cytokine Signaling Pathways and Interactions
- Vagus Nerve Stimulation Research
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Gastrointestinal Tumor Research and Treatment
- Cancer, Lipids, and Metabolism
- Angiogenesis and VEGF in Cancer
- Ferroptosis and cancer prognosis
- Stroke Rehabilitation and Recovery
- Colorectal Cancer Screening and Detection
- Minimally Invasive Surgical Techniques
- Polyamine Metabolism and Applications
- Direction-of-Arrival Estimation Techniques
- Acupuncture Treatment Research Studies
- Cardiomyopathy and Myosin Studies
- Surgical Simulation and Training
- TGF-β signaling in diseases
- Cardiac, Anesthesia and Surgical Outcomes
The First Affiliated Hospital, Sun Yat-sen University
2013-2024
Sun Yat-sen University
2014-2024
Affiliated Hospital of Southwest Medical University
2017-2022
The University of Queensland
2022
Xidian University
2021
Southwest Medical University
2011-2020
First Affiliated Hospital of Sichuan Medical University
2011
Long noncoding RNAs (lncRNAs) have been identified as having functional roles in cancer biology and are deregulated many cancers. The present study aimed to determine the expression, mechanisms of a long RNA CCAT1 progression hepatocellular carcinoma (HCC).CCAT1 expression levels 66 pairs HCC tissues pair-matched noncancerous hepatic were tested by real-time PCR. effects on cells proliferation migration assessed using vitro cell assays. A computational screen microRNAs (miRNAs) target sites...
Angiogenesis is a fundamental process that involves in tumor progression and metastasis. Vascular endothelial growth factor (VEGF) family their receptors are identified as the most prominent regulators of angiogenesis. However, clinical efficacy anti-VEGF/VEGFR therapy not ideal, prompting needs to further understand mechanisms behind Here, we found Dickkopf associated protein 2 (DKK2), secretory highly expressed metastatic colorectal cancer tissues, could stimulate angiogenesis via classic...
AIM:To investigate the clinicopathological significance and prognostic value of caveolin-1 (CAV-1) in both tumor stromal cells colorectal cancer (CRC). METHODS:A total 178 patients with CRC were included this study.The correlation between CAV-1 expression clinicopathologic features survival was studied. RESULTS:CAV-1 detected cells.The closely associated histological type (P = 0.022), pathologic tumor-node-metastasis stage 0.047), N 0.035) recurrence 0.000).However, cell did not show any...
Membrane type 1-matrix metalloproteinase (MT1-MMP) has been identified to play a significant role in several types of cancers, but little is known about the significance MT1-MMP gastric cancer patients. The purpose this study investigate involvement tumor progression cancer. expression levels were examined tissues and cells, normal cells. effects molecular mechanisms on cell proliferation, migration, invasion also explored. In our results, messenger RNA (mRNA) protein significantly increased...
MicroRNA-193b (miRNA-193b) is often differentially expressed and an important regulator of gene expression in colon cancer. The aim the present study was to determine whether miRNA-193b affects cell growth cancer investigate potential underlying mechanisms. Patients with colorectal (CRC; n=20) healthy volunteers (n=10) were enrolled from Department Gastrointestinal Surgery Center, First Affiliated Hospital Sun Yat-Sen University (Guangzhou, China). Western blot analysis used evaluate protein...
To explore possible correlation between serum lactate dehydrogenase (SLDH) levels and gastric cancer. We retrospectively reviewed 365 patients with The of SLDH clinicopathologic features survival rate was studied. were closely associated the pathological (p) T stage (P = 0.011), metastasis 0.012), pTNM 0.001), recurrence 0.012). Moreover, we found a significant level difference among Borrmann type 0.027), pT 0.004), lymph node < 0.006), 0.002). In addition, detected alive dead subgroups...
To evaluate surgical outcomes and prognostic factors for T4 gastric cancer treated with curative resection.Between January 1994 December 2008, 94 patients diagnosed histological carcinoma resection were recruited. Patient characteristics, complications, survival, analyzed.Postoperative morbidity mortality 18.1% 2.1%, respectively. Multivariate analysis indicated lymph node metastasis (hazard ratio, 2.496; 95% confidence interval, 1.218-5.115; p = 0.012) was independent factor.For cancer,...
The aim of the study was to investigate relationship between urokinase-type plasminogen activator (uPA) and mitogen-activated protein kinase 38 (p38MAPK), preliminarily analyze their with clinical characteristics esophageal cancer.Immunohistochemistry Western blot were used detect expressions uPA p38MAPK in patients cancer. them clinicopathological features analyzed by chi-squared test Spearman correlation. Prognosis performed using Kaplan-Meier Cox proportional hazard models analysis.The...
Comparison of transanal specimen extraction (TSE) and transabdominal (TASE) in laparoscopic rectal surgery is still sparsely reported. Trauma, pain, scarring, bad psychological suggestion have long been considered an inevitable outcome surgery. For cancer surgery, whether TSE or TASE beneficial terms technical platforms, indications, contraindications, requirements for aseptic operation, tumor-free prevention treatment complications has not reached a unified consensus standards. Recently,...
The multi-relational Knowledge Base Question Answering (KBQA) system performs multi-hop reasoning over the knowledge graph (KG) to achieve answer. Recent approaches attempt introduce embedding (KGE) technique handle KG incompleteness but only consider triple facts and neglect significant semantic correlation between paths questions. In this paper, we propose a Path Embedding-Enhanced model (PKEEQA), which leverages entities in evaluate ambipolar path question via customizable representation...
During the reentry process of a spacecraft, plasma sheath will attenuate and distort amplitude phase transmitting electromagnetic (EM) waves, influencing signal reception measurement accuracy direction wave arrival spacecraft-borne array antenna, by which spacecraft communication guidance system may be affected. To solve this problem, based on space distribution characteristics flow field, an EM simulation model antenna under is established, simulations related to field propagation across...
Interleukin‑12 receptor (IL‑12R) and p38 mitogen‑activated protein kinase (p38MAPK) serve an important role in non‑small cell lung cancer (NSCLC). It has previously been suggested that IL‑12Rβ2 may be involved key regulatory pathways interacts with the p38MAPK signaling pathway. The present study aimed to elucidate possible association roles of NSCLC. expression levels were measured 230 NSCLC tissue samples by immunohistochemistry (IHC) western blot analyses. In addition, immunofluorescence...