A5048934859- Helicobacter pylori-related gastroenterology studies
- Galectins and Cancer Biology
- TiO2 Photocatalysis and Solar Cells
- Dental materials and restorations
- Dental Erosion and Treatment
- Veterinary medicine and infectious diseases
- Eosinophilic Esophagitis
- Advanced Photocatalysis Techniques
- Microbial Metabolites in Food Biotechnology
- Transition Metal Oxide Nanomaterials
- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Gastrointestinal disorders and treatments
- Electrospun Nanofibers in Biomedical Applications
- Endodontics and Root Canal Treatments
- Bone Metabolism and Diseases
- Mycobacterium research and diagnosis
- dental development and anomalies
- Dental Anxiety and Anesthesia Techniques
- Salivary Gland Disorders and Functions
- Dental Health and Care Utilization
- Conducting polymers and applications
- Periodontal Regeneration and Treatments
- Dental Radiography and Imaging
- Gastroesophageal reflux and treatments
Jeonbuk National University
2019-2025
Chonbuk National University Hospital
2024
Yonsei University College of Dentistry
2009-2022
Yonsei University
2011-2022
Pusan National University
2008-2013
Korea Institute of Fusion Energy
2012
Yonsei University Dental Hospital
2009
Kangwon National University
2003
Helicobacter pylori causes diseases ranging from gastritis to peptic ulcer disease gastric cancer. Geographically, areas with high incidences of H. infection often overlap cancer, which remains one the leading cancer-related deaths worldwide. Strains that carry virulence factor cytotoxin-associated gene A (cagA) are much more likely be associated development Moreover, particular C-terminal polymorphisms in CagA vary by geography and have been suggested influence development. We conducted a...
Gallic acid, a phenolic phytochemical, has been shown to exert variety of effects, including anti-oxidative, anti- carcinogenic, anti-allergic, and anti-inflammatory effects. In this study, we attempted determine whether gallic acid affects metabolic syndrome such as obesity diabetes. Diet-induced mice were treated intraperitoneally once per day with (10 mg/kg/day). After 2 weeks treatment, the sacrificed collect blood for parameter assessments, adipose tissues liver weigh analyze. The...
Gastritis, peptic ulcer disease, and gastric cancer are a few of the diverse disease manifestations that have been shown to be associated with infection by Helicobacter pylori. Why some individuals develop more severe forms remains largely unknown. In this study, 225 South Korean strains were genotyped for vacA then analyzed determine if particular genotypes varied across state, sex, or cagA allele. Of these strains, 206 carried an s1/i1/m1 allele, 11 s1/i1/m2 8 s1/i2/m2 By using Fisher's...
Abstract The periodontal ligament (PDL) is a connective tissue, and PDL cells have potential to differentiate into cementoblasts, osteoblasts, gingival fibroblasts. This study investigated whether transcription factor c‐Myb could induce differentiation of for regeneration. were isolated from extracted teeth cultured. was transfected using replication‐deficient adenoviral vector. Differentiation the analyzed by immunoblot, alkaline phosphatase activity, Alizarin red stain, immunofluorescence...
Abstract Objective This study evaluated whether hypoglycemic drug metformin enhances the anti-cancer effects of cisplatin in YD-9 cells. Methodology cells, derived from oral mucosal squamous cell carcinoma mucosa, were used to assess combined and by means MTT assay, live dead staining, colony formation assays evaluate viability proliferation. Reactive oxygen species level was measured using a Muse analyzer. Apoptosis, epithelial-mesenchymal transition, related molecular pathways analyzed...
Helicobacter pylori-induced gastric inflammation includes induction of inflammatory mediators interleukin (IL)-8 and inducible nitric oxide synthase (iNOS), which are mediated by oxidant-sensitive transcription factor NF-κB. High levels lipid peroxide (LPO) increased activity myeloperoxidase (MPO), a biomarker neutrophil infiltration, observed in H. pylori-infected mucosa. Panax ginseng Meyer, Korean herb medicine, is widely used Asian countries for its biological activities including...
Type 1 diabetes with periodontitis shows elevated TNF-α expression. Tumor necrosis factor (TNF)-α stimulates the expression of receptor activator nuclear factor-κB ligand (RANKL) and sclerostin. The objective this study was to determine effect osteocytic RANKL sclerostin in type rats using infliximab (IFX), a antagonist. Rats were divided into two timepoint groups: day 3 20. Each group then four subgroups: 1) control (C, n = 6 for each time point); 2) (P, 3) (DP, 8 4) treated IFX (DP+IFX,...
The islanding protection for distributed resources (DR) becomes an important and emerging issue in power system since the installations are rapidly increasing most of installed systems interconnected with distribution network. In order to avoid negative impacts from operations DR protection, operation, management system, it is necessary effectively detect disconnect network rapidly. Generally, difficult operation by monitoring only single parameter. This paper presents a new logic based...
Helicobacter pylori is the etiological agent of diseases such as gastritis, gastric and duodenal ulcers, two types cancers. While some insight has been gained into etiology these diverse manifestations, by large, reason that individuals develop more severe disease remains elusive. Recent studies have focused on roles H. toxins CagA VacA process suggested both are intimately involved. Moreover, polymorphic within different strains, particular polymorphisms seem to show a correlation with...
ABSTRACT Infection with Helicobacter pylori is a major risk factor for development of gastric disease, including cancer. Patients infected H. strains that express CagA are at even greater carcinoma. Given the importance CagA, this report describes new molecular mechanism by which cagA copy number dynamically expands and contracts in . Analysis strain PMSS1 revealed heterogeneous population terms numbers copies; carried from zero to four copies were arranged as direct repeats within...
Calcium silicate-based cements (CSCs) are commonly used for endodontic procedures; however, their antibacterial effects limited. The objective of this study was to develop a 2-methacryloyloxyethyl phosphorylcholine (MPC)-incorporated CSC with improved properties, while maintaining the original advantageous features CSC. MPC incorporated into commercial (Endocem MTA) at 0 wt% (control), 1.5%, 3.0 wt%, 5.0 7.5 and 10 wt%. setting time, compressive strength, water sorption, glycerol contact...
Abstract We evaluated the efficacy of light-curable fluoride varnish (LCFV) that contains 2-methacryloyloxyethyl phosphorylcholine (MPC) in terms anti-biofouling properties and prevention tooth enamel demineralization. MPC was mixed with incorporated into LCFV at 0 (control), 1.5, 3.0, 5.0, 10.0, 20.0, 40.0 weight percentage (wt%). Addition high wt% resulted increased film thickness decreased degree conversion, indicating loss advantageous LCFV. 3, or 5 significantly reduced amount bovine...
Helicobacter pylori is the major risk factor for gastric cancer. H. harboring type IV secretion system (T4SS) and its effector CagA encoded on cag pathogenicity Island (cagPAI) increases risk. PMSS1 has a multi-cagA genotype, modulating cagA copy number dynamically from zero to four copies. To examine effect of immune response change, we utilized mouse model with different status. recovered Rag1−/− mice, lacking functional T or B cells, retained more Il10−/− showing intense inflammation, had...
Hydroxyapatite is the main component of enamel that gives tooth a bright white appearance and eliminates diffused reflection light by filling up fine pores surface. Accordingly, remineralization teeth can be expected to some extent if hydroxyapatite used treat an incipient caries lesion (early spot lesion). In addition, effect will increased particle size reduced less than micron-size in existing toothpaste preparations. The aim this vitro study was evaluate nano-hydroxyapatite toothpaste,...
Helicobacter pylori is associated with hypergastrinemia, which has been linked to the development of gastric diseases. Although molecular mechanism not fully understood, H. known modulate Erk pathway for induction gastrin expression. Herein we found that an epidermal growth factor (EGF) receptor kinase inhibitor significantly blocked pylori-induced promoter activity, suggesting involvement EGF ligands. Indeed, induced mRNA expression family members such as amphiregulin, EGF, heparin-binding...
Helicobacter pylori genetic variation is a crucial component of colonization and persistence within the inhospitable niche gastric mucosa. As such, numerous H. genes have been shown to vary in terms presence genomic location this pathogen. Among variable factors, Bab family outer membrane proteins (OMPs) has differ subsets strains. To better understand among bab determine whether differed isolates obtained from different geographic locations, we characterized distribution members 80 American...
The polymorphic CagA toxin is associated with Helicobacter pylori-induced disease. Previous data generated using non-isogenic strains and transfection models suggest that variation surrounding the C-terminal Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs as well number of EPIYA influence disease outcome. To investigate potential CagA-mediated effects on host cell signaling, we constructed characterized a large panel isogenic H. pylori differ primarily in region. EPIYA-C or presence an EPIYA-D motif...