A5102724686- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Advanced biosensing and bioanalysis techniques
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Vector-borne infectious diseases
- Mass Spectrometry Techniques and Applications
- Virus-based gene therapy research
- Advanced Photocatalysis Techniques
- Advanced Sensor and Energy Harvesting Materials
- Calcium signaling and nucleotide metabolism
- Viral gastroenteritis research and epidemiology
- Organ and Tissue Transplantation Research
- Epigenetics and DNA Methylation
- Surface Modification and Superhydrophobicity
- Sirtuins and Resveratrol in Medicine
- Toxin Mechanisms and Immunotoxins
- S100 Proteins and Annexins
- Aerogels and thermal insulation
- Biosensors and Analytical Detection
- Parasitic infections in humans and animals
- Influenza Virus Research Studies
- Glycosylation and Glycoproteins Research
- Caching and Content Delivery
- Network Security and Intrusion Detection
Nanjing University
2021-2025
Southwest University
2025
University of Toronto
2024
University Health Network
2024
Toronto General Hospital
2024
Tsinghua University
2019-2021
Center for Life Sciences
2020-2021
National Institute for Parasitic Diseases
2021
Hospital for Tropical Diseases
2021
Beijing Jiaotong University
2021
BCL6 is required for development of follicular T helper (Tfh) cells to support germinal center (GC) formation. However, it not clear what unique functions programmed by can explain its absolute essentiality in GC We found that ablation one Bcl6 allele did appreciably alter early cell activation and localization but inhibited formation Tfh maintenance. impinged on calcium signaling also controlled entanglement with CD40L delivery B cells. Amounts protein nominal frequencies markedly changed...
Abstract Oral immunosuppression caused by smoking creates a microenvironment to promote the occurrence and development of oral mucosa precancerous lesions. This study aimed investigate role metabolism macrophage polarization in cigarette-promoting leukoplakia. The effects cigarette smoke extract (CSE) on were studied vivo vitro. polarity macrophages was detected flow cytometric analysis qPCR. Liquid chromatography-mass spectrometry (LC-MS) used perform metabolomic Raw cells stimulated with...
Polyimide (PI) aerogels have attracted a great deal of attention due to their low density and excellent heat resistance. However, PI produce large, irregular shrinkage during the thermal imidization process, resulting in decreased porosity strength. In this work, silane coupling agent-modified ultrafine glass fibers (mUGF) were mixed with polyamide acid solution, followed by freeze-drying prepare PI/mUGF aerogels. As inorganic reinforced phase, mUGF high aspect ratio can significantly...
Vascularized composite allotransplantation (VCA) is the transplantation of multiple tissues such as skin, muscle, bone, nerve, and vessels, a functional unit (i.e., hand or face) to patients suffering from major tissue trauma deficits. Though surgical feasibility has been optimized, issues regarding graft rejection remains. VCA involves diverse population cells but primarily driven by both donor recipient lymphocytes, antigen-presenting cells, macrophages, other immune well donor-derived...
A primary immune response is initiated in secondary lymphoid organs. Virtual memory CD8+ T (TVM) cells are antigen-inexperienced of a central phenotype, acquired through self-antigen–driven homeostatic proliferation. Unexpectedly, we find that TVM composed CCR2+ and CCR2− subsets differentially elaborate spectrum effector- memory-poised functions directly the tissue. During influenza infection, rapidly infiltrate lungs first day after infection promote early viral control. recognize antigen...
The exaltation of light-harvesting efficiency and the inhibition fast charge recombination are pivotal to improvement photoelectrochemical (PEC) performance. Herein, a direct Z-scheme heterojunction is designed Cu
O-linked N-acetyl-β-d-glucosamine (O-GlcNAc) is a dynamic post-translational modification that modifies thousands of proteins. However, the roles and mechanisms O-GlcNAcylation have been clarified in only few proteins, one main reasons for this lack site-specific anti-O-GlcNAc antibodies. Recently, we found SIRT1, which an NAD+-dependent deacetylase, O-GlcNAcylated at serine 549 site (S549) plays cytoprotective role under stress. mechanism underlying SIRT1 remains unclear. Here, describe...
Outbreaks of highly pathogenic avian influenza have caused considerable economic losses in the poultry industry and also resulted human deaths since 2004.Rapid subtyping viruses(HPAIVs) clinical specimens is a prerequisite prompt control disease prevention its spreading.In this study, we describe development DNA microarray-based detection HPAIVs field samples.DNA copies matrix (M) protein genes for H5, H7, H9 subtypes hemagglutinin (HA) N1 N2 neuraminidase (NA) were prepared by RT-PCR...
Germinal center (GC) formation is a critical step during T-dependent humoral immune responses. We report Death Associated Protein Kinase 2, serine/threonine kinase, rapidly induced in T cells following activation and plays an inhibitory role cell-mediated help for the GC formation. Specifically, deficient Dapk2 have increased ability to physically conjugate with antigen-presenting B promote However, does not regulate cell receptor signaling strength influence cytokine-driven T-cell subset...
Objective To construct a cDNA library of Babesia microti and immunoscreen candidate antigens for immuno-diagnosis infection.Methods The blood samples were collected from the mice infected with B.microti 7 days post infection when parasitemia density reached 70％.Total RNA was extracted mRNA obtained by purifying kit used to cDNA-library.The immunoscreened pooled sera obtain positive clones.The inserted fragments clones identified PCR amplification,and genes sequenced analyzed their...
In recent years, the rapid development of Programmable Data Plane(PDP) technology provides possibility for large-scale deployment Smart Identifier Network(SINET). As a revolutionary network architecture, SINET supports terminal mobility and extensibility natively by adopting separation identifier locator. At beginning design, security mapping information in publish/query protocol was not considered. same time, because PDP-based using separate control forwarding between plane data is more...
Human sparganosis is a food-borne parasitic disease caused by the plerocercoids of Spirometra species. Clinical diagnosis crucial for effective treatment, thus it important to identify sensitive and specific antigens plerocercoids. The aim current study was characterize immunogenic proteins erinaceieuropaei that were recognized patient sera. Crude soluble extract separated using 2-dimensional gel electrophoresis coupled with immunoblot mass spectrometry analysis. Based on immunoblotting...