A5085623302- 3D Printing in Biomedical Research
- Angiogenesis and VEGF in Cancer
- Electrospun Nanofibers in Biomedical Applications
- Cancer Cells and Metastasis
- CRISPR and Genetic Engineering
- Innovative Microfluidic and Catalytic Techniques Innovation
- Atherosclerosis and Cardiovascular Diseases
- BRCA gene mutations in cancer
- Immune cells in cancer
- DNA Repair Mechanisms
- Phagocytosis and Immune Regulation
- Tissue Engineering and Regenerative Medicine
- CAR-T cell therapy research
Massachusetts Institute of Technology
2021-2024
Harvard–MIT Division of Health Sciences and Technology
2023
Self-organized microvascular networks (MVNs) have become key to the development of many microphysiological models. However, self-organizing nature this process combined with variations between types or batches endothelial cells (ECs) often lead inconsistency failure form functional MVNs. Since interstitial flow (IF) has been reported play a beneficial role in angiogenesis, vasculogenesis, and 3D capillary morphogenesis, we systematically investigated IF plays during neovessel formation...
Abstract Previous studies have developed vascularized tumor spheroid models to demonstrate the impact of intravascular flow on progression and treatment. However, these not been widely adopted so vascularization spheroids in vitro is generally lower than tissues vivo. To improve level, a new strategy introduced form by adding fibroblasts (FBs) sequentially pre‐formed this method with cell lines from kidney, lung, ovary cancer. Tumor made higher FB densities periphery spheroid, which tend...
Micropost-based microfluidic devices are widely used for microvascular network (MVN) formation in diverse research fields. However, consistently generating perfusable MVNs of physiological morphology and dimension has proven to be challenging. Here, how initial seeding parameters determine key characteristics MVN is investigated a robust two-step strategy generate established.
Abstract Endothelial programmed death‐ligand 1 (PD‐L1) expression is higher in tumors than normal tissues. Also, tumoral vasculatures tend to be leakier vessels leading a trans‐endothelial or transmural fluid flow. However, it not clear whether such elevated flow can control endothelial PD‐L1 expression. Here, new microfluidic device developed investigate the relationship between and microvascular networks (MVNs). After treating MVNs with for 24 h, of cells upregulated. Additionally, CD8 T...