A5017522845- Pancreatitis Pathology and Treatment
- Gut microbiota and health
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Clostridium difficile and Clostridium perfringens research
- Tryptophan and brain disorders
- Gastrointestinal motility and disorders
- Inflammatory Bowel Disease
- Enhanced Recovery After Surgery
- Systemic Lupus Erythematosus Research
- Advanced Cellulose Research Studies
- High voltage insulation and dielectric phenomena
- Immunodeficiency and Autoimmune Disorders
- Abdominal vascular conditions and treatments
- Aerogels and thermal insulation
- Abdominal Surgery and Complications
ShenZhen People’s Hospital
2023
Southern Medical University
2023
South China University of Technology
2022
Qiqihar Medical University
2022
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2022
Shanghai University of Traditional Chinese Medicine
2022
Guangzhou First People's Hospital
2010-2013
Guangzhou Medical University
2010-2013
Ulcerative colitis (UC) is a recurrent inflammatory disease related to gut microbiota disorder. Metabolites and their sensors play an important role in the communication between microbes host. Our previous study revealed that G protein-coupled receptor 35 (GPR35) key guardian of kynurenic acid (KA) core element defense responses against damage. However, mechanism remains unknown. In this study, DSS-induced rat model was established 16S rRNA sequencing applied explore influence GPR35-mediated...
To investigate the synergistic activity of infliximab to therapeutic effectiveness octreotide in a rat model acute necrotizing pancreatitis (ANP).Forty Sprague-Dawley rats were randomly divided into sham-operated group (SO), ANP (ANP), (OG), (IG), and combination (CG) (n = 8 each group). The was induced by biliopancreatic duct injection with 4.5% sodium taurocholate solution. Rats OG, IG, CG given tail vein (10 μg/kg), (8 mg/kg), respectively, combined μg/kg) at 6 hours after modeling. All...
Objective To compare the treatment effects of Qingyi Huoxue decoction and infliximab on acute necrosis pancreatitis ( ANP) complicated with MODS in a rat model. Methods 4.5% sodium taurocholate was injected into pancreatic duct to induce ANP The rats were randomly divided 3 groups, group (ANP), QG) , (IG). Rats received injection at dose 8 mg/kg body weight via tail vein 6 h after induction. QG normal saline (20 ml/kg) gastric lavage 4 before h, 9 After 24 all sacrificed, serum levels...
Objective To explore the dose-effect relationship and optimal concentration of sodium taurocholate (NaTc) to establish acute necrosis pancreatitis (ANP) complicating MODS in a rat. Methods 280 SD rats were randomly divided into control group (n =40) 3.5%, 4%, 4.5%, 5% ANP = 60, respectively). groups induced by retrograde injection NaTc solution pancreatic duct rats. Rats each model sacrificed at 1, 3, 6, 12 24 h after induction. Serum amylase, serum total bilirubin, creatinine, blood gas...
Objective To investigate the time-course change of intra-abdominal pressure (IAP), TNF-α in rat with acute necrotizing pancreatitis (ANP) and its mechanism. Methods 80 SD rats were randomly divided into ANP group control group. was induced by retrograde injection 4.5% sodium taurocholate pancreatic duct rats, while saline at same dosage. Eight each killed 1 h, 3 6 12 h 24 respectively. The serum levels amylase, determined;IAP, amount abdominal ascites, pathologic changes evaluated. Results...
Objective To investigate the characteristics of dominant bacteria colonic lavage fluid in patients with diarrhea-predominant irritable bowel syndrome (IBS). Methods Forty-six IBS (observation group) and 46 abdominal pain or discomfort who was excluded (control from January 2016 to 2019 Department Gastroenterology, Shenzhen Longhua District People′s Hospital were selected. During colonoscopy, 2 pieces descending mucosal tissues taken by forceps, then 4 ml collected mucosa extract total...
Abstract Background: Ulcerative colitis (UC) is a recurrent inflammatory disease related to gut microbiota disorder. The metabolites and their sensors play an irreplaceable role in the communication of microbes with host. Our previous study revealed that G protein-coupled receptor 35 (GPR35) was key guardian kynurenic acid (KA) core element defense responses against damage. However, mechanism remains unknown. Results: In this study, DSS-induced rat UC model established 16S rRNA sequencing...