Effects of Qingyi Huoxue decoction and Infliximab on rats with acute necrotizing pancreatitis

• DOI: 10.3760/cma.j.issn.1674-1935.2011.03.017
• Publication Date: 2011-06-20
• Authors: Weidong Li; Lin Jia; Jiahua Qiu; Yaoxing Huang
• Keywords: Decoction

Objective To compare the treatment effects of Qingyi Huoxue decoction and infliximab on acute necrosis pancreatitis ( ANP) complicated with MODS in a rat model. Methods 4.5% sodium taurocholate was injected into pancreatic duct to induce ANP The rats were randomly divided 3 groups, group (ANP), QG) , (IG). Rats received injection at dose 8 mg/kg body weight via tail vein 6 h after induction. QG normal saline (20 ml/kg) gastric lavage 4 before h, 9 After 24 all sacrificed, serum levels amylase, total bilirubin, Cr, TNF-α, diamine oxidase DAO) intra-abdominal pressure (IAP) rate carbon propelling ileum measured. pancreas samples collected for pathological examination. score calculated. Results scores ANP, QG, IG 13.8 ±0.8, 6.1 ±0.4, 3.9 ±0.6, difference statistically significant (P <0.05). TNF-α significantly decreased. In DAO (186.3 ± 10.2 ) 134.6 14.3 149.1 16.3) U/L; rates (53 ±0.1)% (89 (61 ; IAPs (11.8 ±1.5), (4.1±0.8), (5.8 ±1.2) mmHg(1 mmHg=0.133 kPa). IAP AG, decreased when compared that group, but higher than P < 0.05). addition, IG, lower Conclusions effective MODS. But Qinyi promoting gastrointestinal motility, reducing improving intestinal barrier function better those infliximab.

Key words: Pancreatitis, necrotizing; decoction; Infliximab; Intra-abdomind pressure; Intestinal