A5109465158- Liver Disease Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Hepatitis B Virus Studies
- Mesenchymal stem cell research
- Cardiac electrophysiology and arrhythmias
- RNA modifications and cancer
- Animal Genetics and Reproduction
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Ruminant Nutrition and Digestive Physiology
- Muscle Physiology and Disorders
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Hepatitis C virus research
- Eicosanoids and Hypertension Pharmacology
- Heavy metals in environment
- Metabolomics and Mass Spectrometry Studies
- Helminth infection and control
- Rice Cultivation and Yield Improvement
- Gut microbiota and health
- Inflammatory Bowel Disease
- Hormonal Regulation and Hypertension
- Tissue Engineering and Regenerative Medicine
- Lipid metabolism and disorders
AviChina Industry & Technology (China)
2024
Bristol-Myers Squibb (United States)
2023-2024
Bristol-Myers Squibb (Sweden)
2024
Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences
2022-2023
First People's Hospital of Nanning
2021-2023
Research Institute of Animal Husbandry
2023
Yangzhou University
2017-2021
Farmland Irrigation Research Institute
2019-2021
Chongqing Medical University
2021
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021
Atrial fibrosis serves as an important contributor to atrial fibrillation (AF). Recent data have suggested that microRNA-30c (miR-30c) is involved in fibrotic remodelling and cancer development, but the specific role of miR-30c remains unclear. The purpose this study was investigate its underlying mechanisms through vivo vitro experiments. Our results indicate significantly down-regulated rat abdominal aortic constriction (AAC) model cellular induced by transforming growth factor-β1...
Emerging evidence indicates that long noncoding RNAs (lncRNAs) play important roles in the regulation of cell differentiation by acting as competing endogenous RNA (ceRNA). However, regulatory mechanisms lncRNA and lncRNA-associated ceRNA network involved adipogenic chicken preadipocytes remain elusive. Here, we first constructed preadipocyte vitro induction model. Then, identified differentially expressed lncRNAs (DELs), miRNAs (DEMis), mRNAs (DEMs) between differentiated undifferentiated...
Skeletal muscle satellite cells are adult muscle-derived stem receiving increasing attention. Sheep have a greater similarity to human with regard metabolism, life span, proliferation and differentiation, than of the rat mouse. We used 2-step enzymatic digestion differential adhesion methods isolate purify sheep skeletal cells, identified induced differentiation examine their pluripotency. The most efficient method for isolation was type I collagenase trypsin method, best conditions in vitro...
To investigate whether IL28B polymorphisms could affect the treatment response to peginterferon alpha (PEG-IFN) in chronic hepatitis B (CHB) patients Chinese Han population. A total of 212 e antigen (HBeAg)-positive treated with PEG-IFN monotherapy were enrolled this study. Genotype analysis was performed for rs12980275, rs12979860 and rs8099917 using MassArray system. Response defined as cases showing normal aminotransferase (ALT) levels, HBV DNA level < 200 IU/ml HBeAg seroconversion after...
Abstract The prevalence and antithrombotic treatment of atrial fibrillation (AF) in Chinese rural population is not well known. aim this study was to investigate the extent which prescribed for AF patients >60 years. We identified 828 from 36734 residents years Shanghai China. Our data indicated overall rate 2.3% East China 38.9% underwent therapy, including warfarin (5.9%), aspirin (29.6%), clopidogrel (2.9%) combined with (0.5%). Of enrolled subjects, 98.4% had CHA 2 DS -VASc score ≥1,...
The use of unconventional water resources is an effective way to alleviate the scarcity freshwater resources, especially in areas where scarce, but reclaimed abundant. To explore reasonable utilization brackish and water, a pot experiment was carried out study risk secondary soil salinization. set two salinity levels four mixed irrigation ratios as control. results showed that: (1) Soil moisture content, salt pH, ESP, SAR decreased with increase proportion mixture. (2) exchangeable Ca2+...
Wheat is the second most important food crop worldwide, and thus, it to protect both its yield quality. Cadmium (Cd) a heavy metal with strong soil–plant mobility biological toxicity. Thus, screening low-Cd-accumulating genotypes elucidate underlying molecular regulatory mechanisms gene networks related Cd stress may be useful reduce dietary exposure this metal. Here, root transcriptomes of genotype YM16 treated (YT) or not (YC) were analyzed using Illumina Hiseq4000 data. The expression...
Background Acute-on-chronic liver failure (ACLF) is an acute deterioration of established disease. Blocking the TNF (tumor necrosis factor)/TNFR factor receptor) 1 pathway may reduce hepatocyte apoptosis/necrosis, and subsequently decrease mortality during development ACLF. We demonstrated that a long-acting antagonist (soluble receptor: IgG Fc [sTNFR:IgG-Fc]) prevented/reduced by blocking TNF/TNFR1 (TNFRp55) pathway. However, it still unclear if sTNFR:IgG-Fc can inhibit damage Methodology...
Somatic cell nuclear transfer is used to generate genetic models for research and new, genetically modified livestock varieties. Goat fetal fibroblast cells (gFFCs) are the predominant donors in Cashmere goat transgenic cloning, but have disadvantages. We evaluated potential of adipose-derived mesenchymal stem (gADSCs) skeletal muscle-derived satellite (gMDSCs) somatic transfer, evaluating their proliferation, pluripotency, transfection efficiency capacity support full term development...
Abstract Background Ozanimod is approved in multiple countries for the treatment of adults with moderately to severely active ulcerative colitis (UC). A previous post hoc analysis individual outcomes phase 3 True North trial (NCT02435992) identified 5 groups patient-response trajectories ozanimod using group-based trajectory modeling (GBTM) and found that populations fast response had higher rates disease control, including patient-reported intestinal symptoms objective measures activity....
To investigate the contribution of dysfunction maternal hemodynamics to renal impairment in preeclampsia (PE).Urinary protein excretion, serum creatinine, blood urea nitrogen, uric acid, and glomerular filtration rate were assessed 571 pregnant women with PE addition noninvasive hemodynamic monitoring. Patients classified into two groups: (glomerular <90 ml/min/1.73 m², n = 161) normal function (n 410). Cut-off values for parameters calculated using receiver-operating characteristic curve...
The initiation of hepatitis B virus (HBV) replication involves the formation covalently closed circular DNA (cccDNA) and its transcription into pregenomic RNA (pgRNA) in hepatocyte nuclei. regulatory mechanism HBV by acetyltransferase is thus far not well understood, but human has been reported as being involved regulation replication.Depletion KAT8 or HAT1 via interference (RNAi) markedly down-regulated HBV-DNA pgRNA levels HepG2.2.15 cells, with knockdown reducing both HBsAg HBeAg more...
Abstract The nonsynonymous SCN10A single nucleotide polymorphism (SNP) rs6795970 has been reported to associate with PR interval and atrial fibrillation (AF) in strong linkage disequilibrium (LD) the AF-associated SNP rs6800541. In this study, we investigated whether polymorphisms are associated AF recurrence after catheter ablation. A total of 502 consecutive patients who underwent ablation were included. was defined as a documented episode any arrhythmias lasting ≥30 s blanking period 3...
Supplementation of the sheep diet with oats (Avena sativa L.) improves animal growth and meat quality, however effects on intestinal microbes their metabolites was not clear. This study aimed to establish effect dietary oat supplementation rumen colonic microbial abundance explore relationship subsequent changes in digesta metabolites. Twenty Small-tail Han were randomly assigned a containing 30 g/100 g maize straw (Control) or hay (Oat). After 90-days experimental diets, colon collected...
Abstract Background Anaerobic fungi are effective fibre-degrading microorganisms in the digestive tract of horses. However, our understanding their diversity and community structure is limited, especially different parts gastrointestinal tract. Results For first time, high-throughput sequencing technology was used to analyse predict fungal microbial Mongolian The results revealed that richness hindgut horses were much higher than those foregut. foregut dominated by Basidiomycota Ascomycota,...