A5101819589- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Genomic variations and chromosomal abnormalities
- Genetic factors in colorectal cancer
- Metabolism, Diabetes, and Cancer
- FOXO transcription factor regulation
- Biosensors and Analytical Detection
- Pancreatic function and diabetes
- Beetle Biology and Toxicology Studies
- RNA Research and Splicing
- Antimicrobial Peptides and Activities
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- RNA and protein synthesis mechanisms
- Ferroptosis and cancer prognosis
- Chromatin Remodeling and Cancer
Qingdao University of Science and Technology
2023-2025
Anyang Tumor Hospital
2025
Nanjing Medical University
2010-2024
Peking University
2024
Tianjin University of Traditional Chinese Medicine
2024
Chimie Biologique pour le Vivant
2023
Anhui University
2023
Sun Yat-sen University
2017-2020
Cantharidin is an active constituent of mylabris, a traditional Chinese medicine. It potent and selective inhibitor protein phosphatase 2A (PP2A) that plays important role in control cell cycle, apoptosis, cell‐fate determination. Owing to its antitumor activity, cantharidin has been frequently used clinical practice. In the present study, we investigated therapeutic potential pancreatic cancer. efficiently inhibited growth cancer cells, but presented much lighter toxicity effect against...
// Xinxin Si 1, 4 , Ruochen Zang Erbao Zhang 5 Yue Liu Xiao Shi Ershao Lipei Shao Andi Li Nan Yang Han Beijing Pan 6 Zhihong Luan Sun Yujie 2, 3, 1 Key Laboratory of Human Functional Genomics Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China 2 Collaborative Innovation Center for Cancer Medicine, Lab Biomarkers, Prevention and Treatment, 3 State Reproductive Department Cell Biology, Biochemistry Molecular Pathology, First Affiliated Hospital Correspondence to: Sun, email:...
Psychological birth trauma represents a significant global public health concern, with an estimated 45% of new mothers reporting such experience. Researchers mostly focus on the impacts postpartum mental issues, as post-traumatic stress disorder, minimal attention has been given to antecedents psychological trauma. This study seeks investigate correlation between fear childbirth and among Chinese women who have undergone natural childbirth, well mediating role coping styles in association...
Mobility analysis is a crucial element in the research area of transportation systems. Forecasting traffic information offers viable solution to address conflict between increasing demands and limitations infrastructure. Predicting human travel significant aiding various urban management tasks, such as taxi dispatch planning. Machine learning deep methods are favored for their flexibility accuracy. Nowadays, with advent large language models (LLMs), many researchers have combined these...
Background. Approximately 90% of colorectal cancer (CRC) deaths arise from the metastatic dissemination primary tumors. It is difficult to predict metastasis cancer, especially for patients with same pathological subtype and differentiation. Aims. To identify biomarkers predicting CRC metastasis. Patients methods. We collected 19 tumors identical subtype, differentiation, comparable Dukes' stages matched age gender but completely different prognosis. were divided into one high-risk low-risk...
The 279-bp major breakpoint region (mbr) within the 3′-untranslated (3′-UTR) of BCL2 gene is a binding site special AT-rich sequence protein 1 (SATB1) that well known to participate in long-range regulation transcription. Our previous studies have revealed mbr could regulate transcription over 200-kb distance and this regulatory function was closely related SATB1. This study explore underlying mechanism its relevance cellular apoptosis. With chromosome conformation capture (3C) chromatin...
FEN1, a structure selective endonuclease participates in DNA replication and repair, is considered to be an important marker for diagnosing tumor disease. It necessary develop highly sensitive reliable method the detection of FEN1. Herein, photochemical (PEC) fluorescence (FL) dual-mode biosensor was constructed coupled with cleavage actuated rolling circle amplification (RCA), CRISPR/Cas12a photocurrent polarity switching system. In presence branched probe cleaved released 5' flap as primer...
Inherited factors contribute to lung cancer risk, but the mechanism is not well understood. Defining biological consequence of GWAS hits in cancers a promising strategy elucidate inherited mechanisms cancers. The tag-SNP rs753955 (A>G) 13q12.12 highly associated with risk Chinese population. Here, we systematically investigate significance and underlying behind locus vitro vivo.We characterize novel p53-responsive enhancer tissue cell specificity 49-kb high linkage disequilibrium block...
Abstract Background The adenosine-to-inosine (A-to-I) editing in anticodons of tRNAs is critical for wobble base-pairing during translation. This modification produced via deamination on A34 and catalyzed by the adenosine deaminase acting tRNA (ADAT) enzyme. Eukaryotic ADATs are heterodimers composed catalytic subunit ADAT2 structural ADAT3, but their molecular assemblies mechanisms largely unclear. Results Here, we report a 2.8-Å crystal structure Saccharomyces cerevisiae ADAT2/3...
Abstract Forkhead Box O1 (FoxO1) is a key transcription regulator of insulin/IGF-I signaling pathway, and its activity can be increased by dexamethasone (DEX) in several cell types. However, the role FoxO1 DEX-induced pancreatic β-cell dysfunction has not been fully understood. Therefore, this study, we investigated whether could mediate possible underlying mechanisms line RINm5F cells primary rat islet. We found that DEX markedly mRNA protein expression decreased phosphorylation through Akt...
Abstract Prostaglandin E2 (PGE2) is a well-known mediator of β-cell dysfunction in both type 1 and 2 diabetes. We recently reported that down-regulation the Akt pathway activity implicated PGE2-induced pancreatic dysfunction. The aim this study was to further dissect signaling process line HIT-T15 cells primary mouse islets. found PGE2 time-dependently increased c-Jun N-terminal kinase (JNK) activity. JNK inhibition by JNK-specific inhibitor SP600125 reversed PGE2-inhibited...
Triple-negative breast cancer (TNBC) has a high mortality rate and limited treatment options. Tetrahydrocurcumin (THC), major metabolite of curcumin, potential antitumor activities. However, the effects mechanism THC in TNBC remain elusive.
// Xinxin Si 1, 5, * , Yue Liu Jinghuan Lv 6 Haijian Ding 5 Xin A. Zhang 4 Lipei Shao Nan Yang 1 He Cheng Luan Sun Dongliang Zhu Yin Andi Li Xiao Han Yujie 2, 3, Key Laboratory of Human Functional Genomics Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China 2 Collaborative Innovation Center for Cancer Medicine, Biomarkers, Prevention and Treatment, 3 State Reproductive Department Physiology Stephenson Center, University Oklahoma Health Sciences City, Oklahoma, USA Cell...
Although beta-catenin cytoplasmic stabilization and nuclear translocation play a key role in initiation of colorectal cancer (CRC), the mechanisms are far from clear. The aim this study was to investigate relation expressions cyclooxygenase (COX)-2 E-cadherin, gene exon 3 mutation altered distribution beta-catenin, their roles CRC progression prognosis.Expressions COX-2 E-cadherin 96 tissue specimens were detected by immunohistochemistry, screened polymerase chain reaction (PCR) denaturing...
Aberrant expression of special AT-rich binding protein 1 (SATB1), a global genomic organizer, has been associated with various cancers, which raises the question how higher-order chromatin structure contributes to carcinogenesis. Disruption apoptosis is one hallmarks cancer. We previously demonstrated that SATB1 mediated specific long-range chromosomal interactions between mbr enhancer located within 3'-UTR BCL2 gene and promoter regulate during early apoptosis. In present study, we used...
Multifunctional nanomaterials have become a promising nanoplatform for anticancer treatment with tumor specific activation. Here, cancer cell-activated nanocomposite Cu/ZIF-8@MPN@DOX@F127 (CZMDF) was constructed metal phenolic network (MPN)-modified Cu/ZIF-8 and loaded doxorubicin (DOX). CZMDF degraded to release tannic acid (TA), Fe3+, Cu2+, DOX in cells. Benefiting from the reducibility of TA, Fe3+ converted Fe2+, which could react endogenous H2O2 produce highly toxic hydroxyl radical...
The abnormality of p53 tumor suppressor is crucial in lung cancer development, and may regulate target gene promoters to combat cancer. Recent studies have shown extensive binding enhancer elements. However, whether exert a role by shaping the landscape remains poorly understood. In current study, we employed several functional genomics approaches assess activity at sites throughout genome based on our established knockout human bronchial epithelial cells (BEAS-2B). A total 943 active...