A5101465856- Genetic Associations and Epidemiology
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Immune Cell Function and Interaction
- Advanced Glycation End Products research
- Food Quality and Safety Studies
- Nutrition, Genetics, and Disease
- Curcumin's Biomedical Applications
- Neurological Disease Mechanisms and Treatments
- Photoreceptor and optogenetics research
- Ubiquitin and proteasome pathways
- Gout, Hyperuricemia, Uric Acid
- Cardiovascular and exercise physiology
- Hemodynamic Monitoring and Therapy
- Paraoxonase enzyme and polymorphisms
- Lipid Membrane Structure and Behavior
- Wnt/β-catenin signaling in development and cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Heat shock proteins research
- Flavonoids in Medical Research
- Liver Disease Diagnosis and Treatment
- Malaria Research and Control
- Pharmacological Effects of Natural Compounds
- Heart Rate Variability and Autonomic Control
Shanxi Medical University
2010-2024
Tianjin University of Traditional Chinese Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2023
University of Hong Kong
2020
Beijing Hospital
2013-2019
Xinjiang Institute of Materia Medica
2019
Liaoning Cancer Hospital & Institute
2018
Peking Union Medical College Hospital
2014
Academy of Medical Sciences
2014
Neuropathic pain is a chronic disease that severely afflicts the life and emotional status of patients, but currently available treatments are often ineffective. Novel therapeutic targets for alleviation neuropathic urgently needed. Rhodojaponin VI, grayanotoxin from Rhododendron molle, showed remarkable antinociceptive efficacy in models pain, its biotargets mechanisms unknown. Given reversible action rhodojaponin VI narrow range over which structure can be modified, we perforwmed thermal...
Triple-negative breast cancer (TNBC) has a high mortality rate and limited treatment options. Tetrahydrocurcumin (THC), major metabolite of curcumin, potential antitumor activities. However, the effects mechanism THC in TNBC remain elusive.
Background/Aim: Six prostate cancer (PCa) susceptibility loci were identified in a genome-wide association study (GWAS) populations of European decent. However, the associations these 6 single-nucleotide polymorphisms (SNPs) with PCa has remained tobe clarified men Northern China. This aimed to explore associated risk Chinese population. Methods: Blood samples and clinical information 289 patients 288 controls from Beijing Tianjin collected. All SNPs genotyped using polymerase chain reaction...
By means of rational probe design and activity-based protein profiling (ABPP), we found that the secondary-carbon-centered radical predominates in targeting synthetic trioxolane malaria parasites.
The tumor suppressor forkhead box P4 (FOXP4) plays important roles in oncogenesis, and the FOXP4 variant rs1983891 is associated with prostate cancer (PCa) several studies. However, association studies conducted Northern Southern Chinese have provided conflicting results. Therefore, here we performed fine mapping of to identify PCa potential application men.We examined 11 variants spaced approximately 55 kb apart spanning using high-resolution melting-curve analysis sequencing methods 286...
Prostate cancer (PCa) is a multifactorial disease involving complex genetic and environmental factors interactions. Gene-gene gene-environment interactions associated with PCa in Chinese men are less studied. We explored the association between 36 SNPs 574 subjects from northern China. Body mass index (BMI), smoking, alcohol consumption were determined through self-administered questionnaires 134 patients. Then gene-gene among PCa-associated analyzed using generalized multifactor...
Background: KLK3 gene products, like human prostate-specific antigen (PSA), are important biomarkers in the clinical diagnosis of prostate cancer (PCa). G protein-coupled receptor RFX6, C2orf43 and FOXP4 signaling plays roles development PCa. However, associations these genes with PCa northern Chinese men remain to be detailed. This study aimed investigate their impact on occurrence level malignancy. Methods: All subjects were from Beijing Tianjin, including 266 cases 288 normal individuals...
Multiple genetic studies have confirmed association of 8q24 variants with susceptibility to prostate cancer (PCa). As PCa risk SNPs may also influence disease outcome, we studied here eight alleles, and evaluated their role in clinical covariates northern Chinese men. Blood samples information were collected from ethnically men Northern China histologically-confirmed (n=289) age-matched normal controls (n=288). Eight genotyped by polymerase chain reaction-high- resolution melting analysis...
Prostate cancer (PCa) is a leading cause of morbidity and mortality in men worldwide; however, PCa incidence rates vary widely across geographic regions ethnic groups. The current study was designed to elucidate the pivotal factors involved occurrence development.We performed RNA sequencing on prostate tumor adjacent normal tissues from Chinese patients. Genes identified via genome-wide expression profile analysis were validated by quantitative reverse-transcription polymerase chain reaction...
Natural products are an important source of new drugs. Some them may be used directly in clinical settings without further structural modification. One these natural is puerarin (Pue), which protects cardiomyocytes against oxidative stress and high glucose stress. Although Pue has been clinics for many years, its direct binding targets involved the protection not yet fully understood. Here, we reported that could prevent from apoptosis under H2O2 conditions. Based on affinity-based protein...
Shared genetic variants in ADIPOR1 have been identified as closely related to coronary artery disease (CAD), type 2 diabetes (T2D), and T2D with CAD susceptibility, suggesting that these are strong candidates for the common soil hypothesis. Therefore, it is essential analyze relationship between susceptibility CAD, T2D, other populations.A case-control study was conducted which included three case cohorts [CAD (n = 316), 295), 302)], a control cohort 268) from population northeast China. Six...
Abstract Renal fibrosis, a terminal manifestation of chronic kidney disease, is characterized by uncontrolled inflammatory responses, increased oxidative stress, tubular cell death, and imbalanced deposition extracellular matrix. 5,2′‐Dibromo‐2,4′,5′‐trihydroxydiphenylmethanone (LM49), polyphenol derivative synthesized our group with excellent anti‐inflammatory pharmacological properties, has been identified as small‐molecule inducer matrix degradation. Nonetheless, the protective effects...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Second Harmonic Generation Studies of Langmuir-Blodgett Monolayers 4-(N-Docosyl-N-methylamino)-.beta.-nitrostyreneC. K. Park, W. M. P. Wijekoon, C.-F. Zhao, N. PrasadCite this: Chem. Mater. 1994, 6, 10, 1638–1641Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/cm00046a013https://doi.org/10.1021/cm00046a013research-articleACS...