A5101692466- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Liver Disease and Transplantation
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Complement system in diseases
- Inflammasome and immune disorders
- Epigenetics and DNA Methylation
- T-cell and B-cell Immunology
- Iron Metabolism and Disorders
- Cholesterol and Lipid Metabolism
- Hepatitis B Virus Studies
- Pancreatitis Pathology and Treatment
- Cancer-related gene regulation
- Macrophage Migration Inhibitory Factor
- Atherosclerosis and Cardiovascular Diseases
- Blood groups and transfusion
- Phagocytosis and Immune Regulation
- Immunotherapy and Immune Responses
- Sphingolipid Metabolism and Signaling
Shandong University
2016-2022
Shanghai University of Traditional Chinese Medicine
2019-2021
Hunan Normal University
2019-2021
Yueyang Hospital
2019-2021
Xuzhou Medical College
2017-2018
Second People’s Hospital of Huai’an
2017
Nanjing Medical University
2017
Nanjing Drum Tower Hospital
2007
Abnormal expression of activating/inhibitory receptors leads to natural killer (NK) cells dysfunction in tumor. Here we show that programmed cell death protein 1 (PD-1), a well-known immune checkpoint T cells, is highly expressed on peripheral and tumor-infiltrating NK from patients with digestive cancers including esophageal, liver, colorectal, gastric biliary cancer. The increased PD-1 indicates poorer survival esophageal liver cancers. Blocking PD-1/PD-L1 signaling markedly enhances...
Natural killer (NK) cells are enriched within the liver. Apart from conventional NK (cNK) cells, recent studies identified a liver-resident (LrNK) subset, which constitutes about half of hepatic and exhibits distinct developmental, phenotypic, functional features. However, it remains unclear whether how LrNK as well cNK participate in development hepatocellular carcinoma (HCC) individually. Here, we report that both significantly decreased HCC. The T-cell immunoglobulin mucin...
Initiation of hepatocellular carcinoma (HCC) by chronic hepatitis B virus (HBV) infection is a complex process that includes both oncogene activation and tumor suppressor inhibition. The HBV X (HBx) protein has an important role in processes leading to HCC. We previously identified the mammalian Zinc fingers homeoboxes 2 (ZHX2) gene as HCC-associated gene. In present study, we investigated whether oncogenic properties and, more specifically, HBx, involved ZHX2 silencing. Our data indicates...
Macrophages perform key and distinct functions in maintaining tissue homeostasis by finely tuning their activation state. Within the tumor microenvironment, macrophages are reshaped to drive progression. Here we report that necrosis factor α-induced protein 8-like 1 (TIPE1) is highly expressed depletion of TIPE1 impedes alternative macrophages. enhanced PI3K/Akt pathway directly binding with regulating metabolism phosphatidylinositol 4,5-bisphosphate (PIP2) 3,4,5-trisphosphate (PIP3)....
// Yuan Liu 1 , Yong Xu Hongxin Ma Bo Wang Leiqi Hualin Zhang Xiaojia Song Lifen Gao Xiaohong Liang Chunhong Key Laboratory for Experimental Teratology of Ministry Education and Department Immunology, Shandong University School Medicine, Jinan, Shandong, 250012 P.R. China Correspondence to: Liang, e-mail: Liangxiaohong@sdu.edu.cn Ma, machunhong@sdu.edu.cn Keywords: HCC, HBx, PPM1a, TGF-β, tumorigenenesis Received: September 22, 2015 Accepted: April 02, 2016 Published: 21, ABSTRACT...
Siglec-9 is a MHC-independent inhibitory receptor selectively expressed on CD56dim NK cells. Its role in infection diseases has not been investigated yet. Here we studied the potential regulatory roles of pathogenesis chronic hepatitis B (CHB) infection. Flow cytometry evaluated expression and other receptors peripheral Immunofluorescence staining was used to detect ligands liver biopsy tissues cultured hepatocyte cell lines. blocking assay carried out cytokine synthesis CD107a degranulation...
Abstract Increased expression of T cell immunoglobulin and mucin domain‐3 (Tim‐3) on invariant natural killer ( iNKT ) cells is reported in chronic hepatitis B virus HBV infection. However, whether Tim‐3 regulates condition remains unclear. In this study, our results showed that the was up‐regulated hepatic from ‐transgenic (Tg) mice or stimulated with α‐galactosylceramide (α‐Galcer). Compared − cells, + expressed more IFN ‐γ, IL ‐4 CD 107a, indicating a strong relationship between...
The tumor suppressor forkhead box P4 (FOXP4) plays important roles in oncogenesis, and the FOXP4 variant rs1983891 is associated with prostate cancer (PCa) several studies. However, association studies conducted Northern Southern Chinese have provided conflicting results. Therefore, here we performed fine mapping of to identify PCa potential application men.We examined 11 variants spaced approximately 55 kb apart spanning using high-resolution melting-curve analysis sequencing methods 286...