A5047254221- HIV Research and Treatment
- Lipid Membrane Structure and Behavior
- SARS-CoV-2 and COVID-19 Research
- Glycosylation and Glycoproteins Research
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- Alzheimer's disease research and treatments
- HIV/AIDS Research and Interventions
- Sphingolipid Metabolism and Signaling
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Carbohydrate Chemistry and Synthesis
- Bacteriophages and microbial interactions
- Receptor Mechanisms and Signaling
- Protein Structure and Dynamics
- COVID-19 Clinical Research Studies
- Fault Detection and Control Systems
- Lysosomal Storage Disorders Research
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- HIV-related health complications and treatments
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Erythrocyte Function and Pathophysiology
- Parkinson's Disease Mechanisms and Treatments
Inserm
1994-2025
Aix-Marseille Université
2016-2025
Unité de Neurobiologie des canaux Ioniques et de la Synapse
2019-2023
Laboratoire Pluridisciplinaire de Recherche en Ingénierie des Systèmes, Mécanique et Energétique
2013-2020
Université d'Orléans
1996-2020
Institut National des Sciences Appliquées Centre Val de Loire
2019
Physique des interactions ioniques et moléculaires
2010-2017
Cegep de Saint Jerome
2014
Centre National de la Recherche Scientifique
1997-2013
Centre de Recherche en Neurobiologie - Neurophysiologie de Marseille
2009-2012
Magnetic reconnection requires the violation of frozen-in condition which ties gyrating charged particles to magnetic field inhibiting diffusion. Ongoing has been identified in near-Earth space as being responsible for excitation substorms, storms, generation aligned currents and their consequences, wealth auroral phenomena. Its theoretical understanding is now on verge completed. Reconnection takes place thin current sheets. Analytical concepts proceeded gradually down microscopic scale,...
This is a sequel to the previous Perspective "The CH-π hydrogen bond in chemistry. Conformation, supramolecules, optical resolution and interactions involving carbohydrates", which featured PCCP themed issue on "Weak Hydrogen Bonds - Strong Effects?": Phys. Chem. Phys., 2011, 13, 13873-13900. Evidence that weak bonds play an enormously important role chemistry biochemistry has now accumulated extent rigid classical concept of formulated by Pauling needs be seriously revised extended. The...
Cholesterol influences ion-channel function, distribution and clustering in the membrane, endocytosis exocytic sorting of nicotinic acetylcholine receptor (AChR). We report occurrence a cholesterol recognition motif, here coined "CARC", transmembrane regions AChR subunits that bear extensive contact with surrounding lipid are thus optimally suited to convey cholesterol-mediated signaling from latter. Three molecules could be docked on segments each subunit, rendering total 15 per molecule....
The recently emerging SARS-CoV-2 variant omicron displays an unusual association of 30 mutations, 3 deletions, and 1 insertion. To analyze the impact this atypic mutational landscape, we constructed a complete structure spike protein. Compared with delta variant, receptor-binding domain (RBD) has increased electrostatic surface potential, but decreased affinity for ACE-2 receptor. N-terminal (NTD) both potential lower lipid rafts. is predicted to be less fusogenic thus pathogenic than delta,...
The gastrointestinal tract plays a major role in the pathogenesis and pathophysiology of infection by type 1 human immunodeficiency virus (HIV-1). It is potential route for viral entry it site number complications, including both opportunistic infections primary HIV-induced enteropathy. Correspondingly, vivo vitro studies have demonstrated HIV cells lymphoid epithelial origin. HT-29, colonic cell line that infectable with many HIV-1 strains, does not express CD4 protein or mRNA. Recent...
The gastrointestinal tract is considered to be a major route of infection for human immunodeficiency virus (HIV). Infection colon epithelial cells by HIV not blocked anti-CD4 antibodies known block lymphoid (J. Fantini, N. Yahi, and J. C. Chermann, Proc. Natl. Acad. Sci. USA 88:9297-9301, 1991), suggesting the presence an alternate receptor on these cells. In this report, we show that (i) monoclonal antibody specifically directed against galactosyl ceramide inhibited HT29 two markedly...
The V3 loop of the human immunodeficiency virus (HIV)-1 surface envelope glycoprotein gp120 is a sphingolipid-binding domain mediating attachment HIV-1 to plasma membrane microdomains (rafts). Sphingolipid-induced conformational changes in are required for fusion. Galactosylceramide and sphingomyelin have been detected highly purified preparations prion rods, suggesting that protein (PrP) may interact with selected sphingolipids. Moreover, major transition Alzheimer β-amyloid peptide has...
Abstract Calcium-permeable pores formed by small oligomers of amyloid proteins are the primary pathologic species in Alzheimer’s and Parkinson’s diseases. However, molecular mechanisms underlying assembly these toxic plasma membrane brain cells remain unclear. Here we have analyzed compared pore-forming capability a large panel including wild-type, variant truncated forms, as well synthetic peptides derived from specific domains Aβ1-42 α-synuclein. We show that pore formation involves two...
Abstract Cholesterol controls the activity of a wide range membrane receptors through specific interactions and identifying cholesterol recognition motifs is therefore critical for understanding signaling receptor function. The membrane-spanning domains paradigm neurotransmitter acetylcholine (AChR) display series consensus (referred to as “CARC”). Here we use combination molecular modeling, lipid monolayer/mutational approaches NMR spectroscopy study binding synthetic CARC peptide....
Multiple SARS-CoV-2 variants have successively, or concomitantly spread worldwide since the summer of 2020. A few co-infections with different were reported and genetic recombinations, common among coronaviruses, suspected based on co-detection signature mutations in a given genome. Here we report three infections southern France Delta 21J_AY.4-Omicron 21K/BA.1 "Deltamicron" recombinant. The hybrid genome harbors two lineages, supported by mean sequencing depth 1163-1421 reads nucleotide...