A5038670044- Digestive system and related health
- Infant Nutrition and Health
- Diet and metabolism studies
- TGF-β signaling in diseases
- Growth Hormone and Insulin-like Growth Factors
- Helicobacter pylori-related gastroenterology studies
- Hormonal Regulation and Hypertension
- Diet, Metabolism, and Disease
- Cancer-related Molecular Pathways
- Birth, Development, and Health
- Neuropeptides and Animal Physiology
- Neonatal Respiratory Health Research
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Regulation of Appetite and Obesity
- Pancreatic and Hepatic Oncology Research
- Infant Health and Development
- Kruppel-like factors research
- Metabolism, Diabetes, and Cancer
- Fatty Acid Research and Health
- Gastrointestinal motility and disorders
- Apelin-related biomedical research
- Ubiquitin and proteasome pathways
- Breastfeeding Practices and Influences
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Universidade de São Paulo
2015-2025
Hospital Estadual Mário Covas
2023
Universidade Estadual de Campinas (UNICAMP)
2023
Institute of Biomedical Science
2018
New York University
2002-2007
In-Q-Tel
2005
Abstract Background Cachexia is a multifactorial and multiorgan syndrome associated with cancer other chronic diseases characterized by severe involuntary body weight loss, disrupted metabolism, inflammation, anorexia, fatigue, diminished quality of life. This affects around 50% patients colon directly responsible for the death at least 20% all patients. Systemic inflammation has been recently proposed to underline most cachexia‐related symptoms. Nevertheless, exact mechanisms leading...
Abstract Effective treatment for advanced and metastatic tumors remains a major clinical challenge. Chemotherapy has an objective response rate of 40%, reliable predictive biomarkers to guide are lacking. Global implementation Functional Precision Oncology (FPO) offers promising, personalized approach predicting tumor response, with potential improve patient outcomes, optimize resource use, promote equity across diverse geographic regions. This study aims establish validate functional...
Early weaning (EW) increases proliferation of the gastric epithelium in parallel with higher expression transforming growth factor alpha and its receptor epidermal (EGFR). The primary objective present study was to examine involvement EGFR signalling regulating mucosal cell during early period.Fifteen-day-old rats were split into two groups: suckling (control) EW, which pups separated from dam. Animals killed daily until 18th day, 3 days after onset treatment. To investigate role control, EW...
Objective To date, no evidence of robust genotype–phenotype correlation or disease modifiers for multiple endocrine neoplasia type 1 (MEN1) syndrome has been described, leaving the highly variable clinical presentation patients unaccounted for. Design As CDKN1B ( p27 ) gene causes MEN4 and it is transcriptionally regulated by product MEN1 (menin), we sought to analyze whether influences phenotype -mutated patients. The cohort consisted 100 carrying germline mutations 855 population-matched...
High fat diet consumes and thyroid hormones (THs) disorders may affect nutrients metabolism, but their impact on the absorptive epithelium, first place of access, remains unknown. Our aim was to evaluate intestinal morphology transporters content in mice fed standard (LFD) or high (HFD) diets hypo hyperthyroidism-induced condition. C57BL/6 male LFD HFD for 12 weeks, followed by saline, PTU (antithyroid drug) T3 treatment up 30 days. The were euthanized proximal intestine removed study GLUT2,...
Hormones and growth factors regulate endometrial cell growth. Disrupted transforming factor-beta (TGF-beta) signaling in primary carcinoma (ECA) cells leads to loss of TGF-beta-mediated inhibition, which we show herein results lack up-regulation the cyclin-dependent kinase inhibitor p27(Kip1) (p27) arrest G(1) phase cycle. Conversely, normal epithelial (EECs), TGF-beta induces a dose-dependent increase p27 protein, with total 3.6-fold maximal at 100 pmol/L TGF-beta, was 2-fold higher nuclear...
During rat postnatal development, gastric cell proliferation and differentiation depend on many elements, which include dietary pattern, hormones, growth factors their signaling pathways. Among them, EGFR activity is increased through MAPK Src cascades in response to early weaning that represents the abrupt transition from milk solid food. We herein investigated direct involvement of ERK pathway control cycle progression during weaning, studied specific role p27. At 15 days, Wistar rats were...
Abstract Germline mutations in p27 kip1 are associated with increased susceptibility to multiple endocrine neoplasias (MEN) both rats and humans; however, the potential role of common polymorphisms this gene tumor tumorigenesis remains mostly unrecognized. To assess risk polymorphism rs2066827 (p27-V109G), we genotyped a large cohort Brazilian patients sporadic tumors (pituitary adenomas, n =252; pheochromocytomas, =125; medullary thyroid carcinoma, =51; parathyroid =19) 885...
The aim of present study was to evaluate the number and basophily cell bodies myenteric neurons in ileum rats with diabetes mellitus induced by streptozotocin. Four groups were used: two (D) whereas other worked as controls (N). Animals sacrificed six (6N, 6D) or nineteen (19N, 19D) weeks after induction. A segment terminal portion each rat obtained stained Giemsa's solution, for whole-mount preparation studies. Forty fields analyzed animal, intensity recorded. After counting, following mean...
The nutritional status influences gastric growth, and interestingly, whereas cell proliferation is stimulated by fasting in suckling rats, it inhibited adult animals. Corticosterone takes part the mechanisms that govern development, its effects are regulated particular corticosterone-binding globulin (CBG) glucocorticoid receptor (GR). To investigate whether corticosterone activity responds to how possible changes might control epithelial cycle, we evaluated different parameters during...
This epigenome-wide association study in stromal/stem cells (ASCs), derived from subcutaneous adipose tissue samples of lean and obese subjects, revealed a specific DNA methylation signature adipocyte precursors associated with obesity, which has significant impact on the metabolic phenotype mitochondrial function mature adipocytes.
Abstract Gastric epithelial cells differentiate throughout the third postnatal week in rats, and become completely functional by weaning time. When suckling is interrupted early (EW), cell proliferation differentiation change gastric mucosa, regulatory mechanisms might involve corticosterone activity. Here we used EW RU486 (glucocorticoid receptor antagonist) to investigate roles of on mucous neck (MNC) zymogenic (ZC) evaluate whether effects persisted young adults. MNC give rise ZC, mucin...
We discovered that pigment epithelium-derived factor (PEDF)–null mice have endometrial hyperplasia, the precursor to human type I cancer (ECA), which is etiologically linked unopposed estrogen (E2), suggesting this potent antiangiogenic might contribute dysregulated growth and development of ECA. Treatment both ECA cell lines primary cells with recombinant PEDF dose dependently decreased cellular proliferation via an autocrine mechanism by blocking in G1 G2 phases cycle. Consistent known...