A5043051253- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Chronic Disease Management Strategies
- Vaccine Coverage and Hesitancy
- Health disparities and outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Viral Infections and Immunology Research
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Management and Education
- Schizophrenia research and treatment
- Peripheral Neuropathies and Disorders
- COVID-19 and Mental Health
- Obesity and Health Practices
- Frailty in Older Adults
- Liver Disease Diagnosis and Treatment
- COVID-19 epidemiological studies
- Employment and Welfare Studies
- Intensive Care Unit Cognitive Disorders
- Pharmaceutical Practices and Patient Outcomes
- Thyroid Disorders and Treatments
- Animal Virus Infections Studies
- Obesity, Physical Activity, Diet
- Bipolar Disorder and Treatment
University of Hong Kong
2021-2025
Chinese University of Hong Kong
2016-2025
Hong Kong Science and Technology Parks Corporation
2021-2024
Laboratory of Data Discovery for Health
2021-2024
Aston University
2023
Hong Kong Jockey Club
2015-2022
Prince of Wales Hospital
2018-2022
ORCID
2021
Education University of Hong Kong
2016-2017
Objectives To investigate the relationship between COVID-19 full vaccination (two completed doses) and possible arthritis flare. Methods Patients with rheumatoid (RA) were identified from population-based electronic medical records linkage categorised into BNT162b2 (mRNA vaccine), CoronaVac (inactive virus vaccine) non-vaccinated groups. The risk of flare after was compared using a propensity-weighted cohort study design. We defined as hospitalisation outpatient consultation related to RA or...
Case reports suggest that SARS-CoV-2 infection could lead to immune dysregulation and trigger autoimmunity while COVID-19 vaccination is effective against severe outcomes. We aim examine the association between development of autoimmune diseases (ADs), potential protective effect on such an association.A retrospective cohort study was conducted in Hong Kong 1 April 2020 15 November 2022. confirmed by positive polymerase chain reaction or rapid antigen test. Cox proportional hazard regression...
Background: Case reports of carditis after BNT162b2 vaccination are accruing worldwide. Objective: To examine the association and CoronaVac (Sinovac) with carditis. Design: Case–control study hospital control participants. Setting: Territory-wide, public health care database linkage to population-based records in Hong Kong. Patients: Inpatients aged 12 years or older first diagnosed were selected as case patients. All other hospitalized patients without treated Ten participants randomly...
This study aims to evaluate the short- and long-term associations between COVID-19 development of cardiovascular disease (CVD) outcomes mortality in general population.A prospective cohort patients with infection 16 March 2020 30 November was identified from UK Biobank, followed for up 18 months, until 31 August 2021. Based on age (within 5 years) sex, each case randomly matched 10 participants without two cohorts-a contemporary a historical 2018 2018. The characteristics groups were further...
Prior research using electronic health records for Covid-19 vaccine safety monitoring typically focuses on specific disease groups and excludes individuals with multimorbidity, defined as ≥2 chronic conditions. We examine the potential additional risk of adverse events 28 days after first dose CoronaVac or Comirnaty imposed by multimorbidity. Using a territory-wide public healthcare database population-based vaccination in Hong Kong, we analyze retrospective cohort patients Thirty special...
Evidence on post-acute sequelae of SARS-CoV-2 (PASC) has shown inconsistent findings. This study aimed to generate coherent evidence the COVID-19 infection using electronic healthcare records across two regions.In this retrospective, multi-database cohort study, patients with aged 18 or above between April 1st 2020 and May 31st 2022 from Hong Kong Hospital Authority (HKHA) March 16th 2021 UK Biobank (UKB) databases their matched controls were followed for up 28 17 months, respectively....
Abstract The persisting risk of long-term health consequences SARS-CoV-2 infection and the protection against such conferred by COVID-19 vaccination remains unclear. Here we conducted a retrospective territory-wide cohort study on 1,175,277 patients with stratified their status non-infected controls to evaluate clinical sequelae, cardiovascular all-cause mortality using public healthcare database population-based records in Hong Kong. A progressive reduction was observed over one year...
This cohort study assesses the association between single-dose COVID-19 BNT162b2 vaccination regimen and myocarditis risk among vaccinated adolescents in Hong Kong before after policy.
Stimulation of immunity by vaccination may elicit adverse events. There is currently inconclusive evidence on the relationship between herpes zoster related hospitalization and COVID-19 vaccination. This study aimed to evaluate effect inactivated virus (CoronaVac, Sinovac) mRNA (BNT162b2, BioNTech/Fosun Pharma) vaccine risk hospitalization.Self-controlled case series (SCCS) analysis was conducted using data from electronic health records in Hospital Authority Department Health Hong Kong. We...
Accruing evidence suggests an increased risk of myocarditis in adolescents from messenger RNA COVID-19 vaccines. However, other potential adverse events remain under-researched. We conducted a retrospective cohort study aged 12-18 with territory-wide electronic healthcare database the Hong Kong population linked population-based vaccination records and supplemented age- sex-specific numbers. Two sex-matched cohorts were formed to observe 28 days following first second doses BNT162b2 estimate...
Abstract Several studies reported hematological abnormalities after vaccination against the coronavirus disease 2019 (COVID‐19). We evaluated association between COVID‐19 vaccines (CoronaVac and BNT162b2) abnormalities. conducted nested case–control self‐controlled case series analyses using data from Hong Kong Hospital Authority Department of Health, HKSAR. Outcomes interest were thrombocytopenia, leukopenia, neutropenia. Adjusted odds ratios (aORs), incidence rate (IRRs), 95% confidence...
Data regarding protection against mortality and severe complications after Omicron BA.2 infection with CoronaVac BNT162b2 vaccines remains limited. We conducted a case-control study to evaluate the risk of following 1-3 doses using electronic health records database. Cases were adults their first COVID-19-related or between 1 January 31 March 2022, matched up-to 10 controls by age, sex, index date, Charlson Comorbidity Index. Vaccine effectiveness type number was estimated conditional...
Background: Thyroiditis and Graves' disease have been reported after coronavirus 2019 (COVID-19) vaccination. We evaluated the risks of adverse events COVID-19 vaccination among patients treated for hypothyroidism. Methods: In this retrospective population-based cohort study Hong Kong Hospital Authority electronic health records with Department Health linkage, levothyroxine (LT4) users were categorized into unvaccinated, vaccinated BNT162b2 (mRNA vaccine), or CoronaVac (inactivated vaccine)...
This study aims to evaluate the association between thromboembolic events and hemorrhagic stroke following BNT162b2 CoronaVac vaccination.Patients with incident or within 28 days of covid-19 vaccination SARS-CoV-2 positive test during 23 February 30 September 2021 were included. The incidence per 100,000 vaccine doses administered cases estimated. A modified self-controlled case series (SCCS) analysis using data from Hong Kong territory-wide electronic health records. Seasonal effect was...
Whether hospitalized patients benefit from COVID-19 oral antivirals is uncertain.
Importance Literature indicates adverse effects of lithium on thyroid and kidney function. However, existing data are heterogeneous, with limitations in quality lack evaluation vs other mood stabilizers, especially commonly prescribed second-generation antipsychotics. Lithium serum level thresholds associated abnormalities remain unknown. Objective To examine risk dysfunction patients incident bipolar disorder (BD) treated stabilizers antipsychotics an Asian population to determine cutoffs...
Background We examined the association of housing affordability with physical and mental health in Hong Kong, where there is a lack related research despite having worst problem world, considering potential mediating effect deprivation. Methods A stratified random sample 1978 Kong adults were surveyed. Housing was defined using residual-income (after costs) approach. Health-related quality life assessed by Short-Form Health Survey version 2 (SF-12v2), from which component summary (PCS) (MCS)...
Concern about the cardiovascular safety of coronavirus disease 2019 (COVID-19) vaccines among individuals with (CVD) may lead to vaccine hesitancy. We sought assess association between two COVID-19 vaccines, BNT162b2 and CoronaVac, risk major adverse events (MACE) in established CVD.
Background Safety monitoring of coronavirus disease 2019 (COVID-19) vaccines is crucial during mass vaccination rollout to inform the choice and reduce vaccine hesitancy. Considering scant evidence directly comparing safety profiles mRNA inactivated SARS-CoV-2 vaccines, this territory-wide cohort study aims compare incidence various adverse events special interest (AESIs) all-cause mortality between CoronaVac (inactivated vaccine) BNT162b2 (mRNA-based vaccine). Our results can help...