A5052299663- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Mental Health Treatment and Access
- Maternal Mental Health During Pregnancy and Postpartum
- Adolescent and Pediatric Healthcare
- Mental Health Research Topics
- Chronic Disease Management Strategies
- COVID-19 and Mental Health
- Cardiac Health and Mental Health
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Suicide and Self-Harm Studies
- Acute Ischemic Stroke Management
- Mental Health and Psychiatry
- Pregnancy and Medication Impact
- Child and Adolescent Psychosocial and Emotional Development
- Resilience and Mental Health
- Diabetes Management and Education
- Blood Pressure and Hypertension Studies
- Electroconvulsive Therapy Studies
- Cardiovascular Issues in Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Obsessive-Compulsive Spectrum Disorders
- Family Caregiving in Mental Illness
- Maternal and Perinatal Health Interventions
Queen Mary Hospital
2019-2025
University of Hong Kong
2019-2025
Chinese University of Hong Kong
2023-2025
HKU-Pasteur Research Pole
2025
Importance Literature indicates adverse effects of lithium on thyroid and kidney function. However, existing data are heterogeneous, with limitations in quality lack evaluation vs other mood stabilizers, especially commonly prescribed second-generation antipsychotics. Lithium serum level thresholds associated abnormalities remain unknown. Objective To examine risk dysfunction patients incident bipolar disorder (BD) treated stabilizers antipsychotics an Asian population to determine cutoffs...
Abstract Aims Bipolar disorder is associated with premature mortality, but evidence mostly derived from Western countries. There has been no research evaluating shortened lifespan in bipolar using life-years lost (LYLs), which a recently developed mortality metric taking into account illness onset for life expectancy estimation. The current study aimed to examine the extent of patients relative general population Hong Kong (HK) terms standardised ratio (SMR) and excess LYLs, changes rate...
Psychotic disorders are associated with premature mortality, but research was primarily based on Western countries and rarely examined non-affective psychoses other than schizophrenia (ONAP). This population-based cohort study investigated excess mortality in 46 896 20 651 ONAP patients between January 2006 December 2016 Hong Kong (HK), by estimating all-cause cause-specific standardized ratios (SMRs), life-years lost (LYLs), a recently developed, more precise reduced life expectancy measure...
Abstract Negative symptoms are prevalent in the prodromal and first-episode phases of psychosis highly predictive poor clinical outcomes (eg, liability for conversion functioning). However, latent structure negative is unclear early illness. Determining (EP) critical importance identification, prevention, treatment efforts. In current study, confirmatory factor analysis was used to evaluate relation 4 theoretically derived models: 1. a 1-factor model, 2. 2-factor model with expression (EXP)...
Background Schizophrenia patients have markedly elevated prevalence of diabetes compared with the general population. However, risk mortality and diabetes-related complications among schizophrenia co-occurring is understudied. Aims We investigated whether increased overall mortality, post-complication in people diabetes. Method This population-based, propensity-score matched (1:10) cohort study identified 6991 incident pre-existing 68 682 only between 2001 2016 Hong Kong using a medical...
Ischemic heart disease is the leading cause of mortality in psychotic disorders. There a paucity research comprehensively evaluating short-term mortality, cardiovascular complications, and treatment inequality after cardiac events patients with This population-based cohort study examined 30-day 1-year all-cause complication rates, receipt invasive procedures, 90-day post-discharge cardioprotective medication following admission for first-recorded acute coronary syndrome (ACS) among disorders...
Abstract Background There is growing concern regarding teratogenic effect of antipsychotics. Previous research assessing association between antipsychotics and congenital malformations (CMs) yielded mixed results were all derived from Western countries. We aimed to examine risk major organ/system-specific CMs associated with prenatal antipsychotic exposure in Hong Kong. Methods This population-based study identified women aged 15–50 years who delivered their first/singleton child 2003–2018...
Accumulating studies have assessed mortality risk associated with mood-stabilizers, the mainstay treatment for bipolar disorder (BD). However, existing data were mostly restricted to suicide risk, focused on lithium and valproate rarely adequately adjusted potential confounders. This study aimed assess comparative all, natural unnatural causes between lithium, three frequently prescribed second-generation antipsychotics (SGA), adjustment important
Objective: Schizophrenia-spectrum disorder (SSD) is associated with increased premature death, emerging data suggesting early illness course as a high-risk period for excess mortality. This study aimed to examine mortality rate in patients incident SSD and differential risk between inpatient-diagnosed outpatient-diagnosed subsamples within 5 years of first diagnosis. Method: population-based cohort identified 8826 aged 18–39 receiving first-recorded diagnosis upon service entry, comprising...