A5017989868- Reproductive tract infections research
- Drug-Induced Adverse Reactions
- Syphilis Diagnosis and Treatment
- Blood disorders and treatments
- Biosimilars and Bioanalytical Methods
- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Asthma and respiratory diseases
- Pharmaceutical Economics and Policy
- Kawasaki Disease and Coronary Complications
- Autoimmune and Inflammatory Disorders Research
- Sarcoidosis and Beryllium Toxicity Research
- Dermatologic Treatments and Research
- Connective Tissue Growth Factor Research
- Stress Responses and Cortisol
- Renal Diseases and Glomerulopathies
- Ocular Diseases and Behçet’s Syndrome
- Genital Health and Disease
- Virology and Viral Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Substance Abuse Treatment and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- HIV, TB, and STIs Epidemiology
- Food Allergy and Anaphylaxis Research
- SARS-CoV-2 and COVID-19 Research
University of Hong Kong
2016-2024
Queen Mary Hospital
2016-2023
Chinese University of Hong Kong
2023
Hong Kong University of Science and Technology
2022
University of Washington
2019-2021
Pamela Youde Nethersole Eastern Hospital
2016-2019
Tuen Mun Hospital
2016
Objectives To investigate the relationship between COVID-19 full vaccination (two completed doses) and possible arthritis flare. Methods Patients with rheumatoid (RA) were identified from population-based electronic medical records linkage categorised into BNT162b2 (mRNA vaccine), CoronaVac (inactive virus vaccine) non-vaccinated groups. The risk of flare after was compared using a propensity-weighted cohort study design. We defined as hospitalisation outpatient consultation related to RA or...
Abstract Background Pharyngeal gonorrhea is relatively common. However, the duration of untreated pharyngeal unknown. Methods From March 2016 to December 2018, we enrolled 140 men who have sex with in a 48-week cohort study. Participants self-collected specimens and completed survey weekly. Specimens were tested using nucleic acid amplification test at conclusion We estimated incidence infection. defined incident infections as 2 consecutive positive tests, clearance negative tests; and,...
Abstract Recent literature indicates that patients with depression had increased immune activation. We hypothesised treatment-resistant (TRD), an indicator of non-responsive long-term dysregulated inflammation, could be independent risk factor for subsequent autoimmune diseases. performed a cohort study and nested case-control to examine the association between TRD diseases, explore potential sex-specific difference. Using electronic medical records in Hong Kong, we identified 24,576...
The duration of rectal gonococcal and chlamydial infection remains unknown. This basic epidemiologic parameter is needed to understand transmission dynamics.We conducted a prospective, longitudinal, observational cohort study 140 men who have sex with (MSM) at risk gonorrhea chlamydia acquisition. For 48 weeks, enrolled collected swabs (Aptima multi-test kit) home responded an electronic survey about sexual behavior health conditions weekly. Swabs remained untested until participants...
Background: Drug allergies (DA) are immunologically mediated adverse drug reactions and their manifestations depend on a variety of drug- patient-specific factors. The dysregulated immune system underpinning rheumatological diseases may also lead to an increase in hypersensitivity reactions, including DA. higher prevalence reported DA, especially anti-microbials, restricts the medication repertoire for these already immunocompromised patients. However, few studies have examined impact DA...
Objectives Lupus nephritis (LN) remains one of the most severe manifestations in patients with systemic lupus erythematosus (SLE). Onset and overall LN risk among SLE considerably difficult to predict. Utilizing a territory-wide longitudinal cohort over 10 years serial follow-up data, we developed validated stratification strategy predict Chinese – Risk Factors associated disease Erythematosus Nephritis (RIFLE-LN). Methods Demographic data including autoantibody profiles, clinical...
Background Risky alcohol consumption is on the rise among older adults. Biomarkers such as phosphatidylethanol (PEth) have been used to evaluate correspondence between an objective, laboratory‐based biomarker and self‐report of consumption. This study examined relationship PEth, consumption, health indices in a sample community‐dwelling middle‐age adults (aged 35 89) with healthy risky levels Methods Self‐reports were collected using Alcohol Use Disorders Identification Test (AUDIT) Form 30....
Myocarditis is a rare complication of Coronavirus Disease 2019 (COVID-19) vaccination. We report case an elderly female who presented initially with acute myocarditis, fulminant heart failure, and atrial fibrillation after receiving modified ribonucleic acid (mRNA) vaccine (BNT162b2). Unlike other patients vaccine-induced she developed persistent fever, sore throat, polyarthralgia, diffuse macular rash, lymphadenopathy. After extensive investigation, was diagnosed post-vaccination...
<h3>Background</h3> The duration of untreated extragenital gonococcal (GC) and chlamydial infection (CT) is not well defined. <h3>Methods</h3> From March 2016 to December 2018, we enrolled 140 MSM in a 12-month cohort study. Men ≥18 years were eligible if they reported receptive anal intercourse had ≥1 following risks ≤12 months: 1) diagnosis GC, CT or syphilis; 2) methamphetamine poppers use; 3) >2 sex partners ≤2 months >5 months. Enrolled men either tested negative for GC/CT at...
Infections following treatment of rheumatic diseases are common and potentially life threatening. Severe infections may be related to the overall susceptibility in diseases, neutropenia connective tissue as well secondary hypogammaglobulinemia (SHG) due use immunosuppressants. Herein, a case antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with recurrent cytomegalovirus (CMV) SHG was described, followed by discussion pathophysiology, clinical presentation, risk factors,...
Wheat dependent exercised induced anaphylaxis (WDEIA) is common in Asian adult populations especially northern China and Korea. A classical WDEIA case presented with detailed histories, investigations management plans. Serum specific IgE to omega-5 gliadin critical for the diagnosis of WDEIA. Avoidance from wheat exercise are keys prevention anaphylaxis. Omalizumab, a monoclonal antibody against IgE, reserved cases recurrent active physical activity status it an off-label treatment.
Background: Intensified market competition could potentially increase the overall treatment consumption of biosimilars and reduce originator product price; but evidence this effect in diverse regions is scarce. We aimed to assess whether introduction first infliximab biosimilar was associated with changes (originator biosimilars) price infliximab.Methods: Interrupted time series analysis sales data from 2010-2020 obtained IQVIA Multinational Integrated Data Analysis System for eight selected...
Abstract Mesenchymal stem cell therapy (MSCT) is an innovative treatment for rheumatic diseases. Underlying mechanism of how MSCT works in diseases are still uncertain and with various hypotheses. Animal studies show conflicting results mainly attributed by the differences administration methods MSCT, types MSC use randomization procedures. Human so far small scale but satisfactory patients systemic lupus erythematosus (SLE). however, showed less rewarding rheumatoid arthritis (RA) sclerosis...
Abstract Background/Aims Adult-onset Still’s disease is a systemic inflammatory of unknown aetiology. Post-COVID-19 vaccine adult-onset has been reported and was associated with only mild myocarditis. Here we report the first case after mRNA COVID-19 vaccination presenting severe myocarditis acute heart failure cardiogenic shock. Methods We described history patient. Results A 72-year-old Chinese woman developed gradual onset fever, shortness breath, sore throat, generalised arthralgia,...
<h3>Objectives</h3> To study the nailfold capillaroscopic patterns and microangiopathy evolution score (MES) correlate with severity of organ damage in Chinese patients systemic sclerosis (SSc) <h3>Methods</h3> Patients who fulfilled 2013 ACR criteria for SSc were studied. A full physical examination was performed. Blood taken autoantibodies, along a lung function test echocardiogram. The extent skin involvement assessed by modified Rodnan (mRSS). Organ Medsger disease scale. Nailfold...
<h3>Background</h3> Little is known about the natural history of rectal and pharyngeal <i>Mycoplasma genitalium</i> (MG). <h3>Methods</h3> From March 2016 to December 2018, we enrolled 140 high-risk MSM in a 12-month cohort study. Eligibility criteria included: age ≥18 years, report receptive anal intercourse, ≥1 following ≤12 months: (1) gonorrhea, chlamydia or syphilis; (2) methamphetamine popper use, (3) ≥2 sex partners ≤2 months ≥5 months. Each week, men collected swabs completed an...
Delayed hypersensitivity reaction of penicillin is commonly seen, but never reported in pyridium. This case illustrates a patient with delayed after the use augmentin and Skin patch test, surprisingly, confirmed pyridium hypersensitivity.
Rheumatoid arthritis (RA) is chronic inflammatory joint disease with a prevalence of up to 1%. Various extra-articular manifestations have been reported, including rheumatoid arthritis-associated interstitial lung (RA-ILD). RA-ILD contributes significant morbidity and leading cause death in patients RA. Detection involvement therefore important. However, the not well known varies among different studies depending on methods detection. Multiple clinical risk factors novel biomarkers explored....