A5005716153- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Geriatric Care and Nursing Homes
- Salivary Gland Disorders and Functions
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Acute Lymphoblastic Leukemia research
- Autoimmune Bullous Skin Diseases
- Oral microbiology and periodontitis research
- Chronic Disease Management Strategies
- Gout, Hyperuricemia, Uric Acid
- Peripheral Neuropathies and Disorders
- Inflammatory Myopathies and Dermatomyositis
- Chronic Lymphocytic Leukemia Research
- Autoimmune Neurological Disorders and Treatments
- Psoriasis: Treatment and Pathogenesis
- Pericarditis and Cardiac Tamponade
- Dental Erosion and Treatment
- Immunodeficiency and Autoimmune Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Spondyloarthritis Studies and Treatments
- Topic Modeling
- Health and Lifestyle Studies
- Myasthenia Gravis and Thymoma
- Adolescent and Pediatric Healthcare
Queen Elizabeth Hospital
2014-2024
Queen Elizabeth Hospital
2013
Liverpool Hospital
2009
Sydney South West Area Health Service
2009
University of Hong Kong
2008
Dean Health Plan
2006
California State University, Long Beach
2005
To compare the incidence of major adverse cardiovascular events (MACEs), cancer and infective complications in RA patients using Janus kinase (JAKis) TNF (TNFis) inhibitors.
Purpose: Increased lifestyle physical activity, for instance, use of active transport, is a current public health target. Active transport interventions that target stair climbing are consistently successful in English-speaking populations yet unsuccessful Hong Kong. We report two further studies on the Kong Chinese. Methods: Pedestrians mass transit escalator system (study 1) and an air-conditioned shopping mall 2) were encouraged to take stairs their cardiovascular by point-of-choice...
Sjögren's syndrome (SS) patients are prone to caries development due reduction of salivary flow. Topical fluoride is commonly prescribed for prevention. In this 24-month randomized, double-blind, placebo-controlled clinical trial, SS were randomly assigned receive either varnish or placebo gel quarterly. Development and arrest at the coronal root surfaces recorded 12-month compared that baseline. Effect on oral Candida lactobacilli colonization was explored by comparing baseline...
Abstract Thiopurine induced toxicity is associated with defects in the thiopurine methyltransferase (TPMT) gene. TPMT a polymorphic enzyme, most of single nucleotide polymorphisms (SNPs) causing an amino acid change, altering enzymatic activity protein. In this study, we characterize novel patient allele c.719A > C, named TPMT*41, together more common variant *3C G, resulting shift at tyrosine 240 to serine, p.Y240S and cysteine, p.Y240C respectively. We show that heterozygote for C has...
Objectives Lupus nephritis (LN) remains one of the most severe manifestations in patients with systemic lupus erythematosus (SLE). Onset and overall LN risk among SLE considerably difficult to predict. Utilizing a territory-wide longitudinal cohort over 10 years serial follow-up data, we developed validated stratification strategy predict Chinese – Risk Factors associated disease Erythematosus Nephritis (RIFLE-LN). Methods Demographic data including autoantibody profiles, clinical...
This study aimed to investigate the relationships among sicca symptoms, oral health conditions, salivary profiles and Candida in Sjögren’s syndrome (SS) patients. Eighty-five SS patients (mean age = 50.5) 40 healthy non-SS individuals 51.4) were recruited. They self-completed Sicca Symptoms Inventory (SSI). Decayed, missing filled surface (DMFS) scores, flow rates, pH colonization determined. Mean SSI summary scores of 11.1 5.4 respectively (p < 0.001). The most prevalent symptoms eye...
We report a case of 63-year-old Chinese man, having history anti-myeloperoxidase (MPO) antibody anti-neutrophil cytoplasmic (ANCA)-associated pulmonary-renal syndrome 9 years ago, presented with second episode rapidly progressive glomerulonephritis (RPGN) and alveolar haemorrhage compatible anti-glomerular basement membrane (GBM) disease. In first presentation, his anti-GBM was negative. This time, anti-MPO negative, but positive. The long interval sequential development disease after...
Abstract Severe cytopenias in patients with autoimmune conditions treated azathioprine are well‐recognized. Thiopurine methyltransferase (TPMT) enzymatic activity is subject to individual and ethnic variability. Patients low TPMT (poor metabolizers) at high risk of developing severe potentially fatal haematopoietic toxicity. Studies have shown that essentially all TPMT‐deficient will develop toxicity on administration conventional thiopurine dosages (6‐mercaptopurine, azathioprine)....
Two versions of a patient-based DAS (PDAS) 1 and 2 (with without ESR) have been developed validated in RA. The objective this study was to define PDAS1- PDAS2-based criteria for remission, low, moderate high disease activity responses treatment.Using receiver operating characteristic curves, the optimal thresholds PDAS1 PDAS2 that correspond assessor-based (DAS28) Clinical Disease Activity Index (CDAI) statuses were determined. Data from RA patients initiated on disease-modifying drugs used...
Low back pain is one of commonest problems prompting a visit to the family physician. Up 5% patients with chronic low in primary care setting are diagnosed as having spondyloarthritis, which includes prototype disease ankylosing spondylitis. Making diagnosis spondylitis often delayed for years, leading significant pain, impairment quality life, disability and productivity loss. A recent breakthrough treatment spondyloarthritis anti-tumor necrosis factor-alpha biologics, lead rapid relief...
This case report described a 40-year-old lady presented with fever, headache, arthralgia, myalgia, and impaired liver function after returning from the Philippines. Chikungunya virus (CHIKV) dengue serology were negative. Eight weeks initial presentation, she experienced inflammatory polyarthritis mimic rheumatoid arthritis. time CHIKV-IgM was detected, together >4-fold rise of CHIKV-polyvalent-antibody titre. The first negative sample reexamined CHIKV-PCR positive. CHIKV infection...
<h3>Background</h3> Treat-to-target is the standard of care in rheumatoid arthritis (RA). Integral to this regular assessment disease activity. Several tools have been developed and validated allow patients with RA self-assess One these Patient-derived Disease Activity Score (PDAS). Two versions pf PDAS are available: PDAS1 PDAS2. PDAS-2 a composite score that includes patient global activity (PGA), modified health questionnaire (MHAQ), self-assessed 28 swollen joint count (ptSJC28) early...
Aim: Compare systemic lupus erythematosus (SLE) patients with pulmonary hypertension (PH) versus SLE without PH, to study the variables associated PH. Methods: Case–control cross-sectional of from 2006 2011. PH was diagnosed by echocardiogram or cardiac catheterization. Controls were randomly selected no cases: controls ratio 39:69, matching for age and gender. Clinical, serologic profiles outcome analyzed. Results: We identified 39 patients. Anti-ribonucleoprotein positively PH; malar rash...
<h3>Background</h3> MSA test is useful to diagnose IIM and subcategorize patients by disease phenotypes. <h3>Objectives</h3> The study aims evaluate the survival of different patterns. <h3>Methods</h3> An registry had been set up in a tertiary referral centre since 2014 recruiting prevalent incident cases. Patients were followed-up prospectively. This included fulfilling 2017 EULAR/ACR classification criteria for IIM<sup>1</sup> excluded those aged < 18 at onset. Immunoblot EUROLINE...