Background: It is beneficial to evaluate changes in neuroscience research field regarding directions and topics over a defined period. Such information enables stakeholders quickly identify the most influential incorporate latest evidence into research-informed education. To our knowledge, no study reported literature last decade. Therefore, current determined terms with highest citation scores, compared publication shares of areas contributing countries this from 2006 2015 identified...

Systemic activation of the immune system can exert detrimental effects on central nervous system. Periodontitis, a chronic disease oral cavity, is common source systemic inflammation. Neuroinflammation might be result this to accelerate progressive deterioration neuronal functions during aging or exacerbate pre-existing neurodegenerative diseases, such as Alzheimer's disease. With advancing age, increase in body's pro-inflammatory status favors state vulnerability both periodontitis and In...

Abstract – Background: As patient‐centered approaches become more popular, increasing attention is being given to assess the effects of various human health situations on an individual's overall quality life (QoL). Measures have been used in dentistry study orthodontic treatment and oral surgery, but so far little has reported about periodontal disease. Objective: This assessed impact status QoL. Methods: A subsample 767 subjects were selected from a community ( n = 1000) which investigated...

Abstract BACKGROUND Xerostomia is a uniform complication after radiotherapy (RT) for nasopharyngeal carcinoma (NPC). Dosimetric studies suggested that intensity‐modulated RT (IMRT) can spare part of the parotid glands from high‐dose radiation. Disease control and salivary function IMRT early‐stage NPC was studied prospectively. METHODS Thirty‐three patients with T1,N0–N1,M0 were treated 2000 to 2002. The prescribed dose 68–70 grays (Gy) in 34 fractions gross tumor volume, 64–68 Gy planning...

The aim of this study was to biotype and characterize phospholipase, proteinase haemolytic activities oral Candida albicans isolates from 210 Chinese patients with type 2 diabetes mellitus (DM) age- sex-matched healthy controls. Seventy-six 50 C. were obtained DM controls, respectively, using the rinse technique. characterized a biotyping system based on enzyme profiles, carbohydrate assimilation patterns boric acid resistance yeasts, further tested for in vitro activities. major biotypes...

Abstract – Objective: To investigate the relationship of dental anxiety with oral health status and health‐related quality life (OHQoL) among dentate subjects living in Hong Kong. Methods: One thousand Kong residents who were aged 25–64 years predominantly Chinese asked to complete short‐forms Dental Anxiety Inventory (SDAxI) Oral Health Impact Profile (OHIP‐14S). (DMFT index) periodontal statuses [full‐mouth clinical attachment level (CAL)] also assessed. Results: Ninety‐six (9.6%; mean...

Periodontitis and peri-implantitis are oral infectious-inflammatory diseases that share similarities in their pathology etiology. Our objective was to characterize the single-site subgingival submucosal microbiomes of implant-rehabilitated, partially dentate Chinese subjects (n = 18) presenting with both periodontitis peri-implantitis.Subgingival/submucosal plaque samples were collected from four clinically distinct sites each subject: submucosa (DI), periodontal pocket (DT), healthy...

Treponema denticola surface proteins were studied for their biochemical and biological characteristics. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis of detergent extracts whole cells revealed a major protein 53 kDa number minor proteins. Antiserum raised against T. ATCC 35405 reacted with the 53-kDa 72-kDa but not other Immunoelectron microscopy anti-53-kDa-protein antibodies showed that is located on cell. SDS-PAGE unheated samples indicated component...

Abstract – Background: Psychological factors may increase the risk for periodontal diseases. Contemporary conceptualization of stress process supports evaluation at three levels: stressors, moderating and mediating factors, reactions. Objective: This study was undertaken to investigate relationship disease in terms clinical attachment level (CAL) psychosocial stress, making reference major components process. Methods: A cross‐sectional 1000 subjects aged 25–64 years Hong Kong conducted....

Summary Background Complementary and alternative medicine (CAM) use among inflammatory bowel disease (IBD) patients is common. We characterised CAM utilisation assessed its impact on medical adherence in the IBD population. Aim To characterise assess Methods Inflammatory recruited from an out‐patient clinic at a tertiary centre were asked to complete questionnaire utilisation, conventional therapy, demographics communication with their gastroenterologist. Adherence was measured using...

Abstract Aim To determine the prevalence and impact of dentine hypersensitivity ( DH ) on oral health‐related quality life OHRQ oL) in individuals receiving supportive periodontal care SPC ). Materials Methods One hundred two adults were recruited for a cross‐sectional study. Subjects categorized into those who self‐reported 1) or did not 0). Impact oL was assessed using Chinese Condition‐Specific Oral Daily Performance questionnaire CS ‐ OIDP Evaluation included tactile‐stimulation followed...

Abstract Aim This study aimed to evaluate the clinical effectiveness of probiotic Lactobacillus reuteri as an adjunct non‐surgical periodontal therapy (NSPT). Materials and Methods A double‐blind, paralleled‐arm, placebo‐controlled randomized trial was conducted. Probiotics L. or placebo lozenges were randomly prescribed for use twice‐daily 28 days. Primary outcomes attachment levels (CAL) probing pocket depths (PPD). All participants underwent NSPT, follow‐up assessments performed at day 90...

ABSTRACT Prominent antigens of Treponema denticola have been suggested to be mediators the cytopathic effects typically seen in periodontal disease. In present study T. major surface protein (Msp) and surface-expressed chymotrypsinlike protease complex (CTLP), we characterized ability these proteins adhere lyse epithelial cells. Msp CTLP were closely associated spirochete outer membranes. Purified Msp, both native recombinant, bound glutaraldehyde-fixed ligament Adherence was partially...

Background: This study aimed to investigate the interrelationship of in vivo expression lipopolysaccharide‐binding protein (LBP) and membrane‐bound CD14 (mCD14) human gingival tissues as well coexpression Toll‐like receptors (TLR) 2 4 association with periodontal conditions. Methods: Gingival biopsies were collected from 43 subjects chronic periodontitis, including pocket (PoTs) clinically healthy (HT‐Ps), 15 periodontally controls (HT‐Cs). The LBP, CD14, TLR 2, was detected by...

Abstract – Appropriate stress management of patients is essential for smooth running invasive or surgical dental procedures conducted under local anaesthesia. Objective: The current study analysed the effectiveness pre‐operative information provision anxiety reduction during dentoalveolar surgery in with high‐ low‐trait anxiety. Methods: Patients scheduled oral performed by six private practitioners were invited to participate study. They randomly assigned four groups and received following...

A 53-kDa protein from the outer sheath of oral spirochete Treponema denticola was purified to homogeneity and shown reconstitute channels in black lipid bilayer model membranes. The channel had a single-channel conductance 1.8 nS 0.1 M KCl, making this largest porin observed date (estimated diameter, 3.4 nm). Electron micrographs 53-kDa-protein-containing sheaths T. showed regular hexagonal array darker staining pits.

This retrospective study investigated the periodontal conditions distal to mandibular second molars 6-36 months after routine surgical extraction of adjacent impacted third molars.Subjects were randomly selected by systematic sampling from computer records 3211 molar extractions in Hong Kong dental teaching hospital. Records and pre-extraction radiographs cases retrieved. Selected subjects (n = 283) invited for an interview followed a clinical examination. Community Periodontal Index (CPI)...