A5026731946- Service-Oriented Architecture and Web Services
- SARS-CoV-2 and COVID-19 Research
- Attention Deficit Hyperactivity Disorder
- Bipolar Disorder and Treatment
- Diabetes Treatment and Management
- Business Process Modeling and Analysis
- Advanced Software Engineering Methodologies
- Pancreatic function and diabetes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Vaccine Coverage and Hesitancy
- Schizophrenia research and treatment
- Simulation and Modeling Applications
- Cancer-related molecular mechanisms research
- Diabetes Management and Research
- Cancer Immunotherapy and Biomarkers
- Landslides and related hazards
- Pneumonia and Respiratory Infections
- Diabetes and associated disorders
- Pharmaceutical studies and practices
- COVID-19 Clinical Research Studies
- Civil and Geotechnical Engineering Research
- Ferroptosis and cancer prognosis
- Power Systems and Technologies
- Tuberculosis Research and Epidemiology
- Smart Grid and Power Systems
Anhui University of Science and Technology
2024-2025
University of Hong Kong
2020-2024
Qinghai University
2024
Chinese University of Hong Kong
2023-2024
Xi'an Jiaotong University
2024
Peking University
2011-2023
Chinese PLA General Hospital
2021-2023
University College London
2023
Central South University
2021-2022
Xiangya Hospital Central South University
2021-2022
Abstract Background tRNA-derived fragments (tRFs) have been shown to critical regulatory roles in cancer biology. However, the contributions of tRFs colorectal (CRC) remain largely unknown. Methods tRF3008A (a tRFRNA derived from tRNA Val ) was identified by RNA sequencing and validated quantitative reverse transcription PCR. The role CRC progression assessed both vitro vivo, its downstream target genes were cells. pull-down with mass spectrometry AGO-RIP used confirm interaction AGO...
This study aims to evaluate the association between thromboembolic events and hemorrhagic stroke following BNT162b2 CoronaVac vaccination.Patients with incident or within 28 days of covid-19 vaccination SARS-CoV-2 positive test during 23 February 30 September 2021 were included. The incidence per 100,000 vaccine doses administered cases estimated. A modified self-controlled case series (SCCS) analysis using data from Hong Kong territory-wide electronic health records. Seasonal effect was...
BackgroundTimely recognition and appropriate treatment of attention-deficit/hyperactivity disorder (ADHD) are essential to enhance long-term outcomes individuals with ADHD. This study aimed evaluate the multinational trends patterns ADHD medication consumption.MethodsIn this longitudinal trend study, we used pharmaceutical sales data from IQVIA-Multinational Integrated Data Analysis System between 2015 2019, covering 64 countries across world. Consumption rates were expressed as defined...
Background Safety monitoring of coronavirus disease 2019 (COVID-19) vaccines is crucial during mass vaccination rollout to inform the choice and reduce vaccine hesitancy. Considering scant evidence directly comparing safety profiles mRNA inactivated SARS-CoV-2 vaccines, this territory-wide cohort study aims compare incidence various adverse events special interest (AESIs) all-cause mortality between CoronaVac (inactivated vaccine) BNT162b2 (mRNA-based vaccine). Our results can help...
Abstract Previous studies report an association between maternal diabetes mellitus (MDM) and attention-deficit/hyperactivity disorder (ADHD), often overlooking unmeasured confounders such as shared genetics environmental factors. We therefore conducted a multinational cohort study with linked mother–child pairs data in Hong Kong, New Zealand, Taiwan, Finland, Iceland, Norway Sweden to evaluate associations different MDM (any MDM, gestational (GDM) pregestational (PGDM)) ADHD using Cox...
NLRP1 (NLR family, pyrin domain containing 1), the first NLR protein, described to form an inflammasome, plays critical roles in innate immunity and inflammation. However, has not been reported be linked LUAD (lung adenocarcinoma) risk, prognosis, immunotherapy or any other treatments. This research aimed explore prognostic value mechanism of LUAD. We performed bioinformatics analysis on data downloaded from TCGA (The Cancer Genome Atlas) GEO (Gene Expression Omnibus), jointly analyzed with...
<h3>Importance</h3> Evidence for improved clinical outcomes with long-acting injectable antipsychotics (LAIAs) vs oral (OAs) is limited in Asian populations and special patient groups, including older people (>65 years), substance use, early initiators of LAIAs. <h3>Objective</h3> To compare the risk disease relapse, health care adverse events associated use LAIAs OAs among Hong Kong schizophrenia. <h3>Design, Setting, Participants</h3> In this self-controlled case series study,...
The incidence and mortality of hepatocellular carcinoma (HCC) have been increasing around the world. Current guidelines recommend HCC screening in high-risk population. However, strength evidence benefits harms to support recommendation was unclear. objective is systematically synthesize current on screening.
The use of benzodiazepines and/or z-drugs in women childbearing age has increased.The aim the study was to evaluate whether gestational benzodiazepine z-drug exposure is associated with adverse birth and neurodevelopmental outcomes.A population-based cohort including mother-child pairs from 2001 2018 Hong Kong analysed compare gestationally exposed nonexposed children on risk preterm birth, small for age, autism spectrum disorder (ASD), attention-deficit/hyperactivity (ADHD) through...
Abstract Purpose Bipolar disorder (BPD) is often an under‐addressed mental disorder. Limited studies have investigated its epidemiology and drug utilisation in Hong Kong (HK) the United Kingdom (UK) thus local prescribing practices remain unclear. This study aimed to determine prevalence of BPD psychotropic medications as maintenance treatment from 2001–2018 HK UK. Method A retrospective using data Clinical Data Analysis Reporting System IQVIA Medical Research Results The diagnosis UK more...
The mechanical and fracture behaviours of rocks are largely influenced by the rock structure existing flaws. To study effects bedding holes on microfracture behaviour layered limestone, numerical specimens based cohesive zone model (CZM) method were first established. cracks’ initiation, propagation penetration processes during entire loading process used to reveal mechanism limestone under different conditions. angle, hole location number peak stress, failure pattern, length total cracks...