A5051082734- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Education
- Lipoproteins and Cardiovascular Health
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Birth, Development, and Health
- Primary Care and Health Outcomes
- Obesity and Health Practices
- Cancer, Lipids, and Metabolism
- Health Promotion and Cardiovascular Prevention
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Health disparities and outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Disease Management Strategies
- Bariatric Surgery and Outcomes
- Chronic Kidney Disease and Diabetes
- Global Health Workforce Issues
- Adipose Tissue and Metabolism
- Health Policy Implementation Science
- Diet, Metabolism, and Disease
- Diabetes Treatment and Management
- Regulation of Appetite and Obesity
- Clinical practice guidelines implementation
- Pharmaceutical Practices and Patient Outcomes
The University of Melbourne
2016-2025
Western Health
2014-2023
Government of Western Australia Department of Health
2021
Sunshine Hospital
2016-2019
Christ University
2018
Flinders University
2006-2014
Deakin University
2006-2014
Western Hospital
2006-2013
Footscray Hospital
2006-2012
University of Hong Kong
1997-2010
Background— Adipocyte–fatty acid binding protein (A-FABP), a major cytoplasmic in adipocytes, plays central role the development of diabetes and atherosclerotic cardiovascular disease experimental animals. We have previously shown that A-FABP is present bloodstream its circulating levels correlate with metabolic risk factors cross-sectional study. In study, we further evaluated prospective association syndrome (MetS) as defined by updated National Cholesterol Education Program criteria....
Adipocyte fatty acid-binding protein (A-FABP) is abundantly expressed in adipocytes and plays a role glucose homeostasis experimental animals. We have previously shown that circulating A-FABP levels are associated with the metabolic syndrome, which confers an increased risk of type 2 diabetes. Here we investigated whether serum could predict development diabetes 10-year prospective study.Baseline were measured enzyme-linked immunosorbent assay 544 nondiabetic subjects, recruited from Hong...
Low circulating levels of adiponectin, an adipokine with insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, are found in hypertensive patients. Adiponectin replenishment ameliorated hypertension adiponectin-deficient mice or obese, hypoadiponectinemia, suggesting etiologic role adiponectin hypertension. We aimed to determine, this 5-year prospective study, whether hypoadiponectinemia could predict the development a nondiabetic Chinese cohort. A total 577 subjects (249...
Abstract Background Randomised controlled trials demonstrate a 60% reduction in type 2 diabetes incidence through lifestyle modification programmes. The aim of this study is to determine whether such programmes are feasible primary health care. Methods An intervention including 237 individuals 40–75 years age with moderate or high risk developing diabetes. A structured group programme six 90 minute sessions delivered during an eight month period by trained nurses Australian care 2004–2006....
There is a recognized association among depression, diabetes, and cardiovascular disease. The aim of this study was to examine in sample representative the general population whether anxiety, psychological distress are associated with metabolic syndrome its components.Three cross-sectional surveys including clinical health measures were completed rural regions Australia during 2004-2006. A stratified random (n = 1,690, response rate 48%) men women aged 25-84 years selected from electoral...
Gestational diabetes mellitus (GDM) is an increasingly prevalent risk factor for type 2 diabetes. We evaluated the effectiveness of a group-based lifestyle modification program in mothers with prior GDM within their first postnatal year.In this study, 573 women were randomised to either intervention (n = 284) or usual care 289). At baseline, 10% had impaired glucose tolerance and 2% fasting glucose. The prevention comprised one individual session, five group sessions, two telephone sessions....
Background The optimal reference range of homeostasis model assessment insulin resistance (HOMA-IR) in normal Chinese population has not been clearly defined. Here we address this issue using the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS), a prospective population-based cohort study with long-term follow-up. Material & Methods In study, glucose tolerance (NGT), impaired fasting (IFG), (IGT) and type 2 diabetes mellitus (T2DM) were defined according to 1998 World Health...
Patients with insulin-dependent diabetes mellitus (IDDM) have a significantly increased risk of macrovascular disease, particularly if they persistent proteinuria. To determine whether altered levels apolipoprotein(a) [apo(a)], the plasminogenlike glycoprotein potentially atherogenic lipoprotein(a); contribute to atherosclerosis, apo(a) were measured in 107 patients IDDM and compared nondiabetic control subjects male elective coronary artery graft patients. Apo(a) diabetic microalbuminuria...
We investigated the association of metabolic syndrome with new-onset diabetes in Hong Kong Cardiovascular Risk Factor Prevalence Study cohort.We followed up on 1,679 subjects without at baseline. Those a previous diagnosis or those who were receiving drug treatment considered to be diabetic. The remaining underwent 75-g oral glucose tolerance test (OGTT). Diabetes was defined by plasma > =7.0 mmol/l fasting and/or =11.1 2 h.The prevalences baseline 14.5 and 11.4%, respectively, according...
Recent large-scale genome-wide association studies identified novel genetic variants associated with obesity and body mass index (BMI) in addition to the well-described FTO MC4R variants.This study aimed examine 13 previously reported and/or BMI-associated loci for associations Chinese.This was a cross-sectional case-control 470 obese cases (BMI > or =27.5 kg/m(2)) 700 normal-weight controls (18.5 < = BMI 23.0 kg/m(2)).A significant could be replicated (one tailed P 0.05) seven of...
While the American Diabetes Association (ADA) 1997 diagnostic criteria advocate use of fasting plasma glucose only, World Health Organization (WHO) retain standard oral tolerance test (OGTT). The present study evaluated relative merit respective in Chinese.Data collected for Hong Kong Cardiovascular Risk Factor Prevalence Study was analysed. This a representative population-based study, conducted from 1995 to 1996 among 2,900 Chinese subjects aged 25-74 years using 75-g OGTT.The prevalence...
Abstract Objective : Body fat distribution has been reported to differentially contribute the development of cardiovascular risk. We report relative associations between general and central obesity risk factors in 2893 Chinese subjects recruited from Hong Kong population. Research Methods Procedures Anthropometric parameters [waist circumference (WC) BMI], surrogate measures insulin resistance (fasting plasma glucose insulin, oral tolerance test, 2 hours insulin), fasting lipids (total,...
Abstract Background Ethnic diversity is increasing through migration in many developed countries. Evidence indicates that type 2 diabetes mellitus (T2DM) prevalence varies by ethnicity and socio-economic status (SES), settings, migrants experience a disproportionate burden of disease compared with locally-born groups. Given Australia’s multicultural demography, we sought to identify groups at high risk T2DM Victoria, Australia. Methods Using population data from the Australian National...
Objective Gestational Diabetes Mellitus (GDM) increases the risk of type 2 diabetes. A register can be used to follow-up high women for early intervention prevent progression We evaluate performance world's first national gestational diabetes register. Research design and methods Observational study that data linkage merge: (1) pathology from Australian states Victoria (VIC) South Australia (SA); (2) birth records Consultative Council on Obstetric Paediatric Mortality Morbidity (CCOPMM, VIC)...
Community-acquired pneumonia remains a leading cause of hospitalization, mortality, and health care costs worldwide. Randomized clinical trials support the use adjunctive corticosteroids, early progressive mobilization, antibiotic switching rules, dietary interventions in improving outcomes. However, it is uncertain whether implementing these will translate into effectiveness under routine conditions.To evaluate bundle evidence-supported treatments conditions representative population...
Recent studies have shown that C-reactive protein (CRP) predicts future risk of diabetes in healthy Caucasians. We determined whether plasma CRP level was elevated Chinese subjects with impaired glucose tolerance (IGT) and could be used to predict progression type 2 or reversion normal (NGT) these high-risk individuals.A total 228 IGT at baseline from the Hong Kong Cardiovascular Risk Factors Prevalence Study underwent repeat oral testing after years. Plasma high-sensitivity measured their...
Polymorphisms of the gene encoding adiponectin (ADIPOQ) have previously been associated with type 2 diabetes in Europid and Japanese subjects, but not Pima Indians. The aim this study was to determine contribution made by ADIPOQ variants glycaemic status southern Chinese individuals.Sixty unrelated subjects were screened for single-nucleotide polymorphisms (SNPs) direct sequencing. association tagging SNPs outcome 262 impaired glucose tolerance (IGT) examined a 5-year prospective study.We...