A5041542858- Tissue Engineering and Regenerative Medicine
- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Quantum Dots Synthesis And Properties
- Advanced Nanomaterials in Catalysis
- Neuroscience and Neural Engineering
- Gold and Silver Nanoparticles Synthesis and Applications
- Bone Tissue Engineering Materials
- Nerve injury and regeneration
- Extracellular vesicles in disease
- Spectroscopy Techniques in Biomedical and Chemical Research
- Biosensors and Analytical Detection
Stanford University
2023-2024
Pennsylvania State University
2024
Abstract Stem cells are a promising treatment option for various neurological diseases such as stroke, spinal cord injury, and other neurodegenerative disorders. However, the ideal environment to optimize therapeutic potential of remains poorly understood. in native influenced by combination mechanical, chemical, electrical cues proliferation differentiation. Because their controllable properties, conductive hydrogels biomaterials interact with stem cells. Herein, this work develops an...
The rapid and accurate detection of bacteria resistance to β-lactam antibiotics is critical inform optimal treatment prevent overprescription potent antibiotics. Here, we present a fast, culture-independent method for the extended-spectrum β-lactamases (ESBLs) using surface-enhanced Raman scattering (SERS). uses probes that release sulfur-based active molecules in presence β-lactamases. released thiol can be captured by gold nanoparticles, leading amplified signals. A broad-spectrum...
Electrical gradients are fundamental to physiological processes including cell migration, tissue formation, organ development, and response injury regeneration. Current electrical modulation of cells is primarily studied under a uniform field. Here we demonstrate the fabrication conductive gradient hydrogels (CGGs) that display mechanical properties varying local mimicking conditions. The electrically-stimulated CGGs enhanced human mesenchymal stem (hMSC) viability attachment. Cells on...
Stem cell transplantation enhances stroke recovery. A primary mechanism is the release of trophic factors, such as VEGF, BDNF, and CNTF, which are thought to stimulate brain plasticity recovery mechanisms. While promising, treatment efficacy stem restricted by inadequate survival insufficient factor at site. To address this, we have developed a single encapsulation method (SingleStem) using naturally occurring glycolysis process click chemistry strategy modify individual neural progenitor...
Abstract Biodegradable tissue engineering scaffolds have garnered increasing interest for their role in providing mechanical support, promoting regeneration, and eliminating the need removal. However, vivo degradation processes remain challenging to track. Here, a novel biodegradable polymer, N‐methyldiethanolamine (MDEA) Gadolinium(III) diethylenetriamine pentaacetate (Gd‐DTPA) modified photoluminescent polymers (BPLPMGd), which combines near‐infrared (NIR) fluorescence magnetic resonance...