A5079718549- Pain Mechanisms and Treatments
- Knee injuries and reconstruction techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Bone fractures and treatments
- Mindfulness and Compassion Interventions
- Pain Management and Treatment
- Medical and Biological Ozone Research
- Ultrasound and Cavitation Phenomena
- Ultrasound and Hyperthermia Applications
- Veterinary Pharmacology and Anesthesia
- Neurogenesis and neuroplasticity mechanisms
- Laser Applications in Dentistry and Medicine
- Spinal Cord Injury Research
- Nanoparticle-Based Drug Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Signaling Pathways in Disease
- RNA Research and Splicing
Stanford Medicine
2024
Stanford University
2022-2023
Pain Management Institute
2021
Complex regional pain syndrome (CRPS) is a form of chronic post-injury affecting the extremities. The mouse tibial fracture-cast model was developed to enable preclinical study CRPS mechanisms and guide condition-specific drug development. Given inherent limitations reflex measures in mice, we sought characterize pain-like behaviors this more holistically. We evaluated spontaneous evoked naturalistic after injury male mice neutral aversive environments using LabGym. Here, report unique...
Single-molecule fluorescence
Pain comprises of both sensory (nociceptive) and affective (unpleasant) dimensions. In preclinical models, pain has traditionally been assessed using reflexive tests that allow inferences regarding pain's nociceptive component but provide little information about the or motivational pain. Developing capture these components are therefore translationally important. Hence, researchers need to use non-reflexive behavioral assays study perception at level. Mechanical conflict-avoidance (MCA) is...
Pain comprises of both sensory (nociceptive) and affective (unpleasant) dimensions. In preclinical models, pain has traditionally been assessed using reflexive tests that allow inferences regarding pain's nociceptive component but provide little information about the or motivational pain. Developing capture these components are therefore translationally important. Hence, researchers need to use non-reflexive behavioral assays study perception at level. Mechanical conflict-avoidance (MCA) is...
Chronic pain is a common and often debilitating problem that affects 100 million Americans. A better understanding of pain's molecular mechanisms necessary for developing safe effective therapeutics. Microglial activation has been implicated as mediator chronic in numerous preclinical studies; unfortunately, translational efforts using known glial modulators have largely failed, perhaps at least part due to poor specificity the compounds pursued, or an incomplete microglial reactivity. In...
Abstract Ultrasound-activatable drug-loaded nanocarriers enable noninvasive and spatiotemporally-precise on-demand drug delivery throughout the body. However, most systems for ultrasonic uncaging utilize cavitation or heating as release mechanism often incorporate relatively exotic excipients into formulation that together limit drug-loading potential, stability, clinical translatability applicability of these systems. Here we describe an alternate strategy design such in which acoustic...
The tibial fracture-pin model is a mouse of orthopedic trauma and surgery that recapitulates the complex muscle, bone, nerve, connective tissue damage manifests with this type injury in humans. This was developed because previous models did not include simultaneous to multiple types (bone, nerves) were truly representative human trauma. authors therefore modified model. fracture consists unilateral open intramedullary nail (IMN) internal fixation tibialis anterior (TA) muscle injury,...
This study aimed to evaluate pain metrics and gut microbiota differences from human subjects with complex regional syndrome (CRPS) compared cohabitants (HHC) non-cohabitating (biobank) controls. In addition, we longitudinal changes of using a mouse model acute chronic CRPS.
The tibial fracture-pin model is a mouse of orthopedic trauma and surgery that recapitulates the complex muscle, bone, nerve, connective tissue damage manifests with this type injury in humans. This was developed because previous models did not include simultaneous to multiple types (bone, nerves) were truly representative human trauma. authors therefore modified model. fracture consists unilateral open intramedullary nail (IMN) internal fixation tibialis anterior (TA) muscle injury,...