A5039691995- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Mitochondrial Function and Pathology
- Head and Neck Cancer Studies
- Cell death mechanisms and regulation
- Breast Cancer Treatment Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- DNA Repair Mechanisms
- Brain Metastases and Treatment
- ATP Synthase and ATPases Research
- Maternal Mental Health During Pregnancy and Postpartum
- Management of metastatic bone disease
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Pleural and Pulmonary Diseases
Westmead Institute for Medical Research
2019-2025
The University of Sydney
2015-2025
Sydney Local Health District
2020-2025
Children's Medical Research Institute
2021-2025
Westmead Hospital
2018-2025
Blacktown & Mount Druitt Hospital
2025
Westmead Institute
2025
Sydney Children’s Hospitals Network
2020-2024
Cancer Australia
2019-2023
Chris O’Brien Lifehouse
2015-2018
microRNA expression profiling plays an emerging role in cancer classification and identification of therapeutic strategies. In this study, we have evaluated the benefits a joint microRNA-mRNA analysis breast cancer. Matched mRNA global was conducted well-annotated cohort 207 cases with complete 10-year follow-up. Penalized Cox regression including expression, clinical covariates used to identify microRNAs associated distant relapse-free survival (DRFS) that provide independent prognostic...
Background Hypoxia in cancers results the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with poor prognosis. Methods Findings In human cancer cell lines tumours, we found that miR-210 targets mitochondrial iron sulfur scaffold protein ISCU, required for assembly iron-sulfur clusters, cofactors key enzymes involved Krebs cycle, electron transport, metabolism. Down regulation ISCU was major cause induction reactive oxygen species...
To investigate small-nucleolar RNAs (snoRNAs) as reference genes when measuring miRNA expression in tumour samples, given emerging evidence for their role cancer. Four snoRNAs, commonly used normalisation, RNU44, RNU48, RNU43 and RNU6B, known to be associated with pathological factors, were measured by real-time polymerase chain reaction two patient series: 219 breast cancer 46 head neck squamous cell carcinoma (HNSCC). SnoRNA then correlated clinicopathological features prognosis....
Triple-negative breast cancer (TNBC) patients generally have a poor outcome; there is pressing need to identify more effective therapeutic strategies. Clinical trials targeting programmed death 1/programmed ligand 1 (PD1/PDL1) in melanoma and non-small-cell lung reported high response rates, tumoral PDL1 expression has been suggested as potential biomarker enrich for patient these treatments. There are only very limited data date reporting the of TNBC.PDL1 immunohistochemistry was performed...
Hypoxia is an important mechanism of treatment resistance in head and neck squamous cell carcinoma (HNSCC). MicroRNAs are short noncoding RNAs that regulate multiple mRNAs frequently dysregulated cancer. The authors have investigated the role 3 microRNAs, including hypoxia-induced hsa-miR-210, as potential markers hypoxia or prognosis.Three hypoxia-related hsa-miR-21, hsa-miR-10b, were measured 46 samples from patients with HNSCC. Expression levels correlated clinicopathological variables...
Radiotherapy is essential to the treatment of most solid tumors and acquired or innate resistance this therapeutic modality a major clinical problem. Here we show that miR-139-5p potent modulator radiotherapy response in breast cancer via its regulation genes involved multiple DNA repair reactive oxygen species defense pathways. Treatment cells with mimic strongly synergized radiation both
The rates of oropharyngeal cancers such as tonsil are increasing. tumour suppressor protein Programmed Cell Death Protein 4 (PDCD4) has been implicated in the development various human and small RNAs microRNAs (miRNAs) can regulate its expression. However exact regulation PDCD4 by multiple miRNAs squamous cell carcinoma (SCC) is not well understood. Using two independent SCC cohorts with a focus on tonsillar region, we identified miRNA profile differentiating tissue from normal. Both miR-21...
Stereotactic ablative radiotherapy (SABR) is used for treating lung tumors but can cause toxic effects, including life-threatening damage to central structures. Retrospective data suggested that small up 10 cm3 in volume be well controlled with a biologically effective dose less than 100 Gy.
Abstract Introduction Temporary tissue expanders with metallic ports for gradual saline injection are increasingly employed to facilitate breast reconstruction after post‐mastectomy radiotherapy ( PMRT ). Treatment beams therefore pass through a high‐density rare‐earth magnet. Measurements ex vivo suggest attenuation of dose the skin and chest wall at clinical risk relapse. The purpose study was quantify resulting reduction in , compared treatment planning system TPS Methods Sixteen patients...
Patients with advanced NSCLC have heterogenous responses to immune checkpoint inhibitors (ICIs) or without chemotherapy. In NSCLC, the impact of distribution metastatic sites and response systemic therapy combinations remain poorly understood. a retrospective cohort study patients unresectable stage III/IV who received first-line therapy, we sought assess association between site metastases patterns progression. Data regarding demographics, tumour characteristics (including site, size,...