A5073599539- Mosquito-borne diseases and control
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Viral Infections and Outbreaks Research
- Computational Drug Discovery Methods
- Viral Infections and Vectors
- Virology and Viral Diseases
- Enzyme Structure and Function
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Biochemical and Molecular Research
- RNA and protein synthesis mechanisms
- Studies on Chitinases and Chitosanases
- Bacteriophages and microbial interactions
- Enzyme Production and Characterization
- Viral Infections and Immunology Research
- vaccines and immunoinformatics approaches
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Alkaline Phosphatase Research Studies
- Polyamine Metabolism and Applications
- Insect Resistance and Genetics
- Biochemical and Structural Characterization
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
Indian Institute of Technology Roorkee
2016-2025
Indian Agricultural Research Institute
2023
ICMR-National Institute of Virology
2023
Shiv Nadar University
2023
Indian Institute of Technology Indore
2010
University of Delhi
2008
State Street (United States)
2006
Purdue University West Lafayette
2006
All India Institute of Medical Sciences
2001-2004
The rapidly spreading, highly contagious and pathogenic SARS-coronavirus 2 (SARS-CoV-2) associated Coronavirus Disease 2019 (COVID-19) has been declared as a pandemic by the World Health Organization (WHO). novel SARS-CoV-2 enters host cell binding of viral surface spike glycoprotein (S-protein) to cellular angiotensin converting enzyme (ACE2) receptor. virus specific molecular interaction with represents promising therapeutic target for identifying antiviral drugs. repurposing drugs can...
SARS-CoV-2 variant recurrence has emphasized the imperative prerequisite for effective antivirals. The main protease (Mpro) of is crucial viral replication, making it one prime and promising antiviral targets. Mpro features several druggable sites, including active sites allosteric near dimerization interface, that regulate its catalytic activity. This study identified six highly efficacious compounds (WIN-62577, KT185, bexarotene, ledipasvir, diacerein, simepervir) using structure-based...
The RNA-dependent RNA polymerase nsP4 is an integral part of the alphavirus replication complex. To define role in viral and for a structure-function analysis, we expressed Sindbis virus Escherichia coli. core catalytic domain (Delta97nsP4, deletion N-terminal 97 amino acids), which consists predicted containing GDD acid motif required synthesis, was stable against proteolytic degradation during expression. Therefore, recombinant selected mutants were purified to homogeneity. We determined...
Alphaviruses, including Chikungunya (CHIKV) and Venezuelan equine encephalitis virus (VEEV), are among the leading causes of recurrent epidemics all over world. Alphaviral nonstructural protein 1 (nsP1) orchestrates capping nascent viral RNA via its S-adenosyl methionine-dependent N-7-methyltransferase (MTase) guanylyltransferase activities. Here, we developed validated a novel capillary electrophoresis (CE)-based assay for measuring MTase activity purified VEEV CHIKV nsP1. We employed to...
The Coronavirus Disease 2019, caused by the severe acute respiratory syndrome coronavirus 2 is an exceptionally contagious disease that leads to global epidemics with elevated mortality and morbidity. There are currently no efficacious drugs targeting therefore, it urgent requirement for development of control this emerging disease. Owing importance nucleocapsid protein, present study focuses on N-terminal domain protein from identify potential compounds computational approaches such as...
Staphylococcus aureus is considered as one of the most widespread bacterial pathogens and continues to be a prevalent cause mortality morbidity across globe. FmtA key factor linked with methicillin resistance in S. aureus. Consequently, new antibacterial compounds are crucial combat resistance. Here, we present virtual screening set against available crystal structure FmtA. The findings indicate that gemifloxacin, paromomycin, streptomycin, tobramycin were top-ranked potential drug molecules...
Chikungunya virus (CHIKV) has frequently recurred in recent decades, causing outbreaks worldwide tropical and subtropical regions. The re-emergence of CHIKV poses a substantial risk to human health, as no efficacious drugs are currently available curb new outbreaks. Here, the anti-CHIKV activity efavirenz was investigated by vitro cell culture-based antiviral assays different relevant lines. Efavirenz is non-nucleoside reverse transcriptase inhibitor (NNRTI) used for treatment acquired...
Abstract Chikungunya virus (CHIKV) capsid protein (CVCP) is a serine protease that possesses cis -proteolytic activity essential for the structural polyprotein processing and plays key role in life cycle. CHIKV being an emerging arthropod-borne pathogenic virus, public health concern worldwide. No vaccines or specific antiviral treatment currently available chikungunya disease. Thus, it important to develop inhibitors against enzymes block steps viral reproduction. In view of this, CVCP was...