A5025173068- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Advanced NMR Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Advanced Neuroimaging Techniques and Applications
- NMR spectroscopy and applications
- Medical Imaging Techniques and Applications
- Molecular spectroscopy and chirality
- Neurological Disease Mechanisms and Treatments
- Lanthanide and Transition Metal Complexes
- Radiomics and Machine Learning in Medical Imaging
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Nanoparticle-Based Drug Delivery
- Prostate Cancer Treatment and Research
- Electron Spin Resonance Studies
- Chemical Synthesis and Analysis
- Solid-state spectroscopy and crystallography
- Liver Disease Diagnosis and Treatment
- Molecular Biology Techniques and Applications
- Microbial Metabolites in Food Biotechnology
- Diet and metabolism studies
- Celiac Disease Research and Management
- Spectroscopy and Quantum Chemical Studies
Continental (Germany)
2018-2024
Institute for Biomedicine
2018-2024
UNICEF East Asia and Pacific Regional Office
2018-2024
All India Institute of Medical Sciences
2014-2023
Chettinad Academy of Research and Education
2020-2023
Indian Institute of Technology Bombay
2023
Indian Institute of Technology Madras
2021-2022
Chettinad Health City
2021-2022
Sri Ramachandra Institute of Higher Education and Research
2021-2022
All India Institute of Medical Sciences Raipur
2003-2020
Abstract Measurements of tumor apparent diffusion coefficient (ADC), volume and diameter in assessing the response patients with locally advanced breast cancer (LABC) (n = 56) undergoing neoadjuvant chemotherapy (NACT) at four time periods (before treatment after three cycles NACT) were carried out 1.5 T using diffusion‐weighted imaging (DWI) MRI. Ten benign tumors 15 controls also investigated. The MR was compared clinical response. Mean ADC before malignant tissue significantly lower than...
Results of the proton magnetic resonance spectroscopy carried out on normal, benign breast disease and locally advanced cancer patients are presented. The in-vivo MR spectra malignant tissue (n = 67) suffering from infiltrating ductal carcinoma dominated by water resonance, while unaffected contralateral these mainly arising lipids which is similar to normal obtained volunteers (controls, n 16). In addition lipid peaks, in majority (∼80%) suppressed showed a at 3.2 ppm due choline containing...
Exercising complementary roles of polymer-coated magnetic nanoparticles for precise drug delivery and image contrast agents has attracted significant attention in biomedical applications. The objective this study was to prepare characterize embedded polylactide-co-glycolide matrixes (PLGA-MNPs) as a dual imaging system capable encapsulating both hydrophilic hydrophobic drugs. PLGA-MNPs were drugs 2:1 ratio. Biocompatibility, cellular uptake, cytotoxicity, membrane potential, apoptosis...
Abstract Background Among the naturally occurring compounds, turmeric from dried rhizome of plant Curcuma longa has long been used extensively as a condiment and household remedy all over Southeast Asia. Turmeric contains essential oil, yellow pigments (curcuminoids), starch oleoresin. The present study was designed for investigating neuroprotective efficacy time window effective therapeutic use oil (C. oil). Method In study, effect post ischemic treatment C.oil after ischemia induced by...
Results are reported on in vivo volume localized proton magnetic resonance spectroscopy (MRS) of patients (n = 44) suffering from carcinoma the breast, using a bilateral breast surface coil. Localized MR spectra unaffected contralateral these dominated by resonances arising fat and similar to tissue normal volunteers (controls, n 13), while malignant tissues water dominates. On other hand, suppressed reveal several metabolites low concentration including choline peak around 3.2 ppm...
The potential of total choline (tCho) signal-to-noise ratio (SNR) (ChoSNR) and tumor volume in the assessment response locally advanced breast cancer (LABC) patients (n = 30) undergoing neoadjuvant chemotherapy (NACT) was investigated using magnetic resonance spectroscopic imaging (MRSI) conventional MRI at 1.5 T. Experiments were carried out sequentially four time-points: prior to therapy after I, II III NACT ChoSNR, measured. MR compared with clinical response. Sequential data 25...
Vitamin D deficiency is prevalent worldwide. supplementation has shown variable effect on skeletal muscle strength in the elderly with hypovitaminosis D. There a paucity of similar data young individuals.To study cholecalciferol and calcium energy metabolism individuals.Forty healthy volunteers (24 M/16 F, mean age (SD) 31.5 ± 5.0 year) were randomized to either oral (60,000 IU D3/week for 8 weeks followed by 60,000 IU/month 4 months) 1 g elemental daily or dual placebos 6 months.Handgrip...
Abstract: The purpose of the study was to develop tumor specific, water dispersible superparamagnetic iron oxide nanoparticles (SPIONs) and evaluate their efficacy as a contrast agent in magnetic resonance imaging (MRI). We have developed SPIONs capped with citric acid/2-bromo-2-methylpropionic acid which are compact, dispersible, biocompatible having narrow range size dispersity (8–10 nm), relatively high T 2 relaxivity (R = 222L · mmol -1 sec -l ). targeting unconjugated folic...
The role of apparent diffusion coefficient (ADC) in the diagnosis breast cancer and its association with molecular biomarkers was investigated 259 patients cancer, 67 benign pathology, 54 healthy volunteers using diffusion-weighted imaging (DWI) at 1.5 T. In 59 patients, dynamic contrast-enhanced MRI (DCEMRI) also acquired. Mean ADC malignant lesions significantly lower (1.02 ± 0.17 × 10(-3) mm(2)/s) compared to (1.57 0.26 (1.78 0.13 tissues. A cutoff value 1.23 mm(2)/s (sensitivity 92.5%;...
Summary 1. Stroke causes brain injury in millions of people worldwide each year. Despite the enormity problem, there is currently no approved therapy that can reduce infarct size or neurological disability. One approaches be used limiting damage after stroke use prophylactic treatment patients with a high‐risk stroke. The present study was undertaken to investigate effect Indian herbal plant Withania somnifera as middle cerebral artery (MCA) occlusion model rats. 2. Two groups male Wistar...
Abstract Purpose To evaluate the use of water‐to‐fat (W‐F) value obtained from in vivo proton ( 1 H) MR spectroscopy (MRS) as a response indicator cytologically confirmed patients with locally advanced breast cancer (LABC), and to monitor therapeutic such neoadjuvant chemotherapy (NACT) Materials Methods Serial H spectra were recorded both before after completion 33 LABC (with infiltrating ductal carcinoma (IDC)) at 1.5T. In addition, normal tissues 28 healthy volunteers recorded. Results...
Abstract Determination of the apparent diffusion coefficient (ADC) prostate in men ( n = 60) with raised prostate‐specific antigen (PSA) or an abnormal digital rectal examination (DRE) prior to transrectal ultrasound (TRUS) guided biopsy using endorectal DWI is reported. Patients were categorized into different groups based on their PSA levels. The mean ADC was calculated from a number regions interest (ROIs) for whole peripheral zone (PZ) and central gland (CG). A total 1108 ROIs analyzed...