A5046031048- Immune Response and Inflammation
- Cervical Cancer and HPV Research
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Bioactive Compounds and Antitumor Agents
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
- Synthesis and biological activity
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- Cancer Mechanisms and Therapy
- Advanced Breast Cancer Therapies
- Veterinary medicine and infectious diseases
- Computational Drug Discovery Methods
- Multicomponent Synthesis of Heterocycles
- Traditional and Medicinal Uses of Annonaceae
- Diverse Scientific Research Studies
- Microbial infections and disease research
- Synthesis and Biological Evaluation
- Reproductive tract infections research
- Peripheral Neuropathies and Disorders
- COVID-19 Clinical Research Studies
- Hepatitis B Virus Studies
- Botulinum Toxin and Related Neurological Disorders
Charotar University of Science and Technology
2018-2024
Louisiana State University Health Sciences Center Shreveport
2024
Single nucleotide polymorphisms (SNPs) in TLR genes may serve as a crucial marker for early susceptibility of various cancers including cervical cancer. The present study was therefore designed to ascertain the role TLR4 and TLR9 SNPs haplotypes hrHPV infection cancer susceptibility. included 110 biopsies 141 smears from age-matched healthy controls Gujarati ethnicity Western India. 16 18 were detected using Real-time PCR. Eight SNPs, four each analyzed Polymerase Chain Reaction-Restriction...
A series of novel pyrazoline scaffolds from coumarin-carbazole chalcones were synthesized. We explored various acetyl, amide, and phenyl substituents at the
Cervicitis is one of the major health problems amongst women caused by infection various pathogens including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV) as well human papillomavirus (HPV), and persistent cervical inflammation etiologic agents cancer. Toll-like receptors (TLRs) play an important role in recognition subsequent elimination these pathogens. Variations receptor genes influence susceptibility to disease progression independently.Ten single...
Abstract Psoralea corylifolia (syn. Cullen corylifolium ), commonly called bawachi, is a medicinal plant extensively used for skin conditions like leukoderma, vitiligo, and psoriasis. It notably rich in valuable bioactive compounds, particularly coumarins furanocoumarins. This study isolated fourteen from P. which were tested cytotoxicity using the MTT assay, with compound 10 showing good against A549 cells (IC 50 0.9 μM), while 1 , 2 3 displaying potential MDA‐MB‐231 0.49 μM, 0.56 0.84 μM...
Many natural and synthetic flavonoids have been studied documented by inhibiting aromatase enzymes for their anti-cancer activity against breast carcinoma. The enzyme is a possible target the estrogen's positive cancer receptor.Hence, series of synthesized assessed in vitro cytotoxicity inhibitory activity.39 Flavonoids were characterized spectroscopic techniques, computational study was performed using maestro version Schrodinger. In silico ADME properties checked QikProp software. A total...
Imidazo[1,2-a]pyridine exerts a notable pharmacological efficiency and has emerged as an integral backbone for the treatment of various cancer.Inhibition cyclin-dependent kinases potential therapeutic strategy variety cancers.Here, we discuss synthesis imidazo[1,2-a]pyridine derivatives modified at positions 6 8 prepared using Suzuki-Miyaura crosscoupling, Buchwald reaction, peptide coupling main synthetic methods.All synthesized compounds were characterized by spectroscopy techniques after...
<ns4:p><ns4:bold>Background:</ns4:bold> Toll-like receptor 9 (TLR9) plays a key role in the elimination of viral pathogens by recognising their CpG DNA. Polymorphisms <ns4:italic>TLR9</ns4:italic> gene may influence recognition and subsequent elimination. Therefore, present study was designed to elucidate rare unexplored polymorphism C296T/ Pro99Leu (rs5743844) cervical cancer susceptibility among Indian women.</ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>The genotyping 110 patients 141...
The SARS-CoV-2 virus, accountable for the COVID-19 pandemic, is now sweeping globe.As a result, as this disease resists testing and adoption of new treatments, repositioning existing medications may provide quick appealing method with established safety, features, dose used.They are not, however, specific or focused.However, numerous have been studied their efficacy safety in treatment COVID-19, majority currently undergoing clinical trials.The goal to rapidly expand novel preventative...
<ns4:p><ns4:bold>Background:</ns4:bold> Toll-like receptor 9 (TLR9) plays a key role in the elimination of viral pathogens by recognising their CpG DNA. Polymorphisms <ns4:italic>TLR9</ns4:italic> gene may influence recognition and subsequent elimination. Therefore, present study was designed to elucidate rare unexplored polymorphism C296T/ Pro99Leu (rs5743844) cervical cancer susceptibility among Indian women.</ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>The genotyping 110 patients 141...