A5056268397- Glioma Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Medical Imaging Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Cancer-related cognitive impairment studies
- Intracranial Aneurysms: Treatment and Complications
- Fetal and Pediatric Neurological Disorders
- Brain Tumor Detection and Classification
- Cerebrospinal fluid and hydrocephalus
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Head and Neck Surgical Oncology
- Prenatal Screening and Diagnostics
- Acute Ischemic Stroke Management
- Multiple Sclerosis Research Studies
- Medical Imaging and Pathology Studies
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Functional Brain Connectivity Studies
- Neurosurgical Procedures and Complications
University of California, San Diego
2015-2024
Saint John's Health Center
2024
UC San Diego Health System
2020
Oxford University Press (United Kingdom)
2018
United States Nuclear Regulatory Commission
2013-2018
Neurosciences Institute
2018
University of California System
2016
Laerdal (Norway)
2013
University of California San Diego Medical Center
2011
VA San Diego Healthcare System
2008
Introduction Diffusion Weighted Imaging (DWI), which is based on Echo Planar (EPI) protocols, becoming increasingly important for neurosurgical applications. However, its use in this context limited part by significant spatial distortion inherent to EPI. Method We evaluated an efficient algorithm EPI correction (EPIC) across 814 DWI scans from 250 brain tumor patients and quantified the magnitude of geometric whole multiple regions. Results Evaluation algorithm’s performance revealed...
Background and purpose Brain radiotherapy is limited in part by damage to white matter, contributing neurocognitive decline. We utilized diffusion tensor imaging (DTI) with multiple b-values (diffusion weightings) model the dose-dependency time course of radiation effects on matter. Materials methods Fifteen patients high-grade gliomas treated chemotherapy underwent MRI DTI prior radiotherapy, after months 1, 4–6, 9–11. Diffusion tensors were calculated using three weightings (high,...
Restriction spectrum imaging is a sensitive DWI technique for probing separable water diffusion compartments in tissues. Here, we evaluate RSI-CMs derived from the spherically-restricted compartment improved tumor conspicuity and delineation nontumor tissue reduced sensitivity to edema compared with high-b-value ADC.RSI was performed 10 presurgical patients: 4 glioblastoma, 3 primary CNS lymphoma, metastatic brain tumors. Multidirectional data were collected at b = 500, 1500, 4000 s/mm(2)....
To determine the ability of fully automated volumetric magnetic resonance (MR) imaging to depict hippocampal atrophy (HA) and help correctly lateralize seizure focus in patients with temporal lobe epilepsy (TLE).This study was conducted institutional review board approval compliance HIPAA regulations. Volumetric MR data were analyzed for 34 TLE 116 control subjects. Structural volumes calculated by using U.S. Food Drug Administration-cleared software quantitative analysis (NeuroQuant)....
Base of tongue squamous cell carcinoma (BOTSCC) is a prevalent and aggressive form oral cancer, often associated with poor patient outcomes. The tumor microenvironment (TME) HPV-positive BOTSCC critical in influencing cancer progression treatment response. This study aims to analyze the TME by examining expression key genes involved various biological processes. We utilized RT2 Profiler PCR Array quantify 168 related inflammation, immunity, oncogenesis, suppression, apoptosis, angiogenesis....
Abstract Stereotactic radiosurgery planning for cerebral arteriovenous malformations (AVM) is complicated by the variability in appearance of an AVM nidus across different imaging modalities. We developed a deep learning approach to automatically segment cerebrovascular-anatomical maps from multiple high-resolution magnetic resonance imaging/angiography (MRI/MRA) sequences patients, with goal facilitating target delineation. Twenty-three patients who were evaluated and underwent...
<h3>BACKGROUND AND PURPOSE:</h3> DTI is being increasingly used to visualize critical white matter tracts adjacent brain tumors before neurosurgical resection. However, tumors, particularly high-grade gliomas, are typically surrounded by regions of FLAIR hyperintensity that include edema, which increase isotropic diffusion, degrading the ability standard uncover orientation estimates within these regions. We introduce a new technique, RSI, overcomes this limitation removing spherical, fast...
Evaluation recommendations for patients on anticoagulant and antiplatelet (ACAP) therapy that present after mild traumatic brain injury (TBI) are controversial. At our institution, an initial noncontrast head computed tomography (HCT) is performed, with a subsequent HCT performed six hours later to exclude delayed intracranial hemorrhage (ICH). This study was evaluate the yield advisability of this approach.We retrospective review subjects undergoing evaluation ICH TBI in ACAP between...
<h3>BACKGROUND AND PURPOSE:</h3> Antiangiogenic therapies, such as bevacizumab, decrease contrast enhancement and FLAIR hyperintensity in patients with high-grade gliomas a manner that may not correlate actual tumor response. This study evaluated the ability of an advanced DWI technique, restriction spectrum imaging, to improve conspicuity within regions restricted diffusion compared ADC treated bevacizumab demonstrate unlike ADC, imaging is less affected by bevacizumab-induced reductions...
Importance: With the increasing use of antiangiogenic agents in treatment high grade gliomas, we are becoming increasingly aware distinctive imaging findings seen a subset patients treated with these agents. Of particular interest is development regions marked and persistent restricted diffusion. We describe case histopathologic validation, confirming that this region diffusion represents necrosis not viable tumor. Observations: present report 52-year-old man GBM temozolomide, radiation,...
Diffusion-weighted imaging has shown initial promise for evaluating response to bevacizumab in patients with high-grade glioma (HGG). However, it is well recognized that the apparent diffusion coefficient (ADC) influenced by bevacizumab-induced reductions edema, which may limit its prognostic value. We demonstrate an advanced diffusion-weighted technique, restriction spectrum (RSI), improves evaluation of because unlike ADC, RSI not affected resolution edema. and ADC maps were analyzed 40...