A5101501393- Acute Myeloid Leukemia Research
- Aquaculture disease management and microbiota
- VLSI and FPGA Design Techniques
- VLSI and Analog Circuit Testing
- Immune cells in cancer
- Histone Deacetylase Inhibitors Research
- MRI in cancer diagnosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Seismology and Earthquake Studies
- Aquaculture Nutrition and Growth
- Protein Degradation and Inhibitors
- Radiomics and Machine Learning in Medical Imaging
- Low-power high-performance VLSI design
- Seismic Waves and Analysis
- Immune Cell Function and Interaction
- Earthquake Detection and Analysis
- Glioma Diagnosis and Treatment
- Supramolecular Chemistry and Complexes
- Chemotherapy-induced organ toxicity mitigation
- solar cell performance optimization
- Single-cell and spatial transcriptomics
- Aquatic life and conservation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vibrio bacteria research studies
- Corrosion Behavior and Inhibition
The University of Tokyo
2022-2024
National Taiwan Ocean University
2013-2024
Ube Frontier University
2024
National Taiwan University
2007-2023
National Taiwan University Hospital
2023
Chang Gung Memorial Hospital
2023
Luodong Poh-Ai Hospital
2023
National Kaohsiung University of Science and Technology
2022
Chung Shan Medical University
2022
Genomics Research Center, Academia Sinica
2020
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-associated phenomenon characterized by clonal expansion blood cells harboring somatic mutations in hematopoietic genes, including DNMT3A, TET2, and ASXL1. Clinical evidence suggests that CHIP highly prevalent associated with poor prognosis solid-tumor patients. However, whether play a causal role promoting the development solid tumors remained unclear. Using conditional knock-in mice express CHIP-associated mutant Asxl1...
With the rapid advances in mobile communication technologies, QR code embedded camera devices has been used as new input interfaces. However, previous works for extracting from an image do not consider a non-uniform background. In this paper, we implement applications of and propose efficient algorithm to extract contrast with prior works, our approach is higher accuracy QR-code recognition more practical use information environment.
Invertebrates rely on an innate immune system to combat invading pathogens. The is initiated in the presence of cell wall components from microbes like lipopolysaccharide (LPS), β-1,3-glucan (βG) and peptidoglycan (PG), altogether known as pathogen-associated molecular patterns (PAMPs), via a recognition pattern protein (PRP) or receptor (PRR) through complicated reactions. We show herein that shrimp hemocytes incubated with LPS, βG, PG caused necrosis released endogenous molecules (EMs),...
Abstract The cumulative absolute absement (CAA) of the 3 s window after P-wave arrival can be used to estimate magnitude ( $${M}_{CAA}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mi>M</mml:mi><mml:mrow><mml:mi>CAA</mml:mi></mml:mrow></mml:msub></mml:math> ) an earthquake. This method achieve good results even when only six stations nearest epicenter are used. standard deviation between estimated CAA and moment $${M}_{w}$$...
<h3>BACKGROUND AND PURPOSE:</h3> Treatment with bevacizumab is standard of care for recurrent high-grade gliomas; however, monitoring response to treatment following remains a challenge. The purpose this study was determine whether quantifying the sharpness fluid-attenuated inversion recovery hyperintense border using measure derived from texture analysis—edge contrast—improves evaluation in patients gliomas. <h3>MATERIALS METHODS:</h3> MRIs were evaluated 33 gliomas before and after...
Monocytic acute myeloid leukemia (AML) responds poorly to current treatments, including venetoclax-based therapy. We conducted in vivo and vitro CRISPR-Cas9 library screenings using a mouse monocytic AML model identified SETDB1 its binding partners (ATF7IP TRIM33) as crucial tumor promoters vivo. The growth-inhibitory effect of Setdb1 depletion is dependent mainly on natural killer (NK) cell-mediated cytotoxicity. Mechanistically, upregulates interferon-stimulated genes NKG2D ligands through...
Most geophysical inverse problems deal with models of the continuous Earth structure. The classical Backus‐Gilbert's theory demonstrates that resolvable model variation is truth viewed through resolution kernel woven by data kernels. actual numerical amounts to inversion Gram matrix formed inner products among However, due usually sizable amount constraints and/or imperfection forward theory, practical implementations are tackled certain a priori finite parameterizations based on rather...
Simple cyclophanes containing four distant amino N atoms or ether O behave as hosts for the threading of guest diarylguanidinium ions. The recognition system exhibits high synthetic flexibility, allowing unique O-free [2]rotaxanes to be synthesized efficiently (yields up 80%) through both "threading-followed-by-stoppering" and "clipping" approaches.
A robust redistribution layer (RDL) router is required for advanced package designs, where the length-matching constraint a group of nets needs to be considered preserve good timing properties at level. For area-I/O flip-chip design with pre-assigned on RDLs, we propose first group-based routing framework that can simultaneously minimize wirelengths an arbitrary and without equal-length constraints, based equal-length-aware A*-search algorithm bounded sliceline grid (BSG) snaking one....
With the vast amounts of data recorded by CWB seismic networks, a fast and precise algorithm for near real-time earthquake locations as well fundamentally urgent source hazard studies large damaging earthquakes in Taiwan becomes increasingly important.Here we present novel method automatic phase identification event detection, modified from Python-based PhasePApy package to be more computationally efficient suitable high-rate seismicity large-scale dense network Taiwan.The performance...
The emerging design requirements with the FinFET technology, along traditional geometrical constraints, make FinFET-based analog placement even more challenging. Previous works can handle only partial FinFET-induced constraints because some new are intrinsically different from ones; as a result, directly extending previous methods to would incur solution quality degradation and runtime overhead. To remedy these disadvantages, we present hybrid graph (meshed tree) representation of window...
We report a new slippage system based on p-tert-butylbenzyl-terminated imidazolium ions and di(ethylene glycol)-containing macrocycles their use as linking units for the construction of prototypical molecular "Lock & Lock" box from resorcinarene-based cavitand "bowl" porphyrin "cover". The multivalent structure with four linkers provided high stability, yet dissociated into its two components upon application suitable external stimuli.
Anti-cancer glyco-peptides inhibit the thrombin-protease activated receptor-1 interaction in exosite I without affecting active-site mediated coagulation activity.
Cisplatin has been considered a chemotherapeutic drug for treating human tumors, and one of the noteworthy side effects cisplatin is nephrotoxicity. Amelioration cisplatin-induced nephrotoxicity necessary. Lotus seedpod extract (LSE) mainly composed quercetin-3-glucuronide revealed antioxidant anti-tumor effects. However, LSE on are still unknown. This study aims to explore in vitro vivo protective effect possible mechanism Results showed that co-treatment with raised viability rat renal...
<title>Abstract</title> Acute erythroleukemia (AEL) is a rare subtype of acute myeloid leukemia with poor prognosis. In this study, we established novel murine AEL model <italic>Trp53</italic> depletion and ERG overexpression. overexpression in <italic>Trp53</italic>-deficient mouse bone marrow cells, but not wild-type leads to development within two months after transplantation 100% penetrance. The cells expressing Cas9 can be cultured <italic>in vitro</italic>, induce vivo</italic> even...
Summary Certain somatic mutations confer a fitness advantage in hematopoietic stem and progenitor cells (HSPCs) over normal HSPCs, resulting the clonal expansion of mutant blood 1 , otherwise known as haematopoiesis (CH). CH is frequently observed among healthy elderly people closely associated with risk cardiovascular diseases (CVDs). The most mutated genes include DNMT3A, TET2 ASXL1 2 . Among them, even though are clinically highest for developing CVDs, little whether how contribute to...