A5046501238- Plant-Microbe Interactions and Immunity
- Minerals Flotation and Separation Techniques
- Catalytic C–H Functionalization Methods
- Acoustic Wave Resonator Technologies
- Legume Nitrogen Fixing Symbiosis
- Synthesis of Organic Compounds
- Oxidative Organic Chemistry Reactions
- X-ray Diffraction in Crystallography
- Iron oxide chemistry and applications
- Monoclonal and Polyclonal Antibodies Research
- Plant Stress Responses and Tolerance
- Crystallization and Solubility Studies
- Colorectal Cancer Surgical Treatments
- Glycosylation and Glycoproteins Research
- Advanced Biosensing Techniques and Applications
- Gastric Cancer Management and Outcomes
- Plant Pathogenic Bacteria Studies
- Asymmetric Synthesis and Catalysis
- Plant Parasitism and Resistance
- Multicomponent Synthesis of Heterocycles
- Cyclopropane Reaction Mechanisms
- Molecular Junctions and Nanostructures
- Chemical synthesis and alkaloids
- Radical Photochemical Reactions
- Carbohydrate Chemistry and Synthesis
University of British Columbia
2020-2025
Kunming University of Science and Technology
2023-2025
Changchun University of Chinese Medicine
2025
Sichuan University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Second Affiliated Hospital of Dalian Medical University
2025
Dalian Medical University
2025
Johannes Gutenberg University Mainz
2024
Anhui University
2024
Venus Medtech (China)
2024
Abstract A synthetic protocol was developed to synthesize highly functionalized 3‐furylmethyl chromones from enynones and o ‐hydroxyphenyl enaminones via silver‐catalyzed cascade bis‐heteroannulation reaction. This strategy features broad substrate scope good functional group tolerance. Furthermore, the chromone skeleton shows potential application value through further gram‐scale synthesis derivatization.
A chemodivergent and skeleton-controllable annulation reactions of readily available o -HPEs aryldiazonium salts was described for the synthesis highly functionalized pyridazine-fused chromones with high antiviral activity higher safety.
An unprecedented selective chromone annulation reaction controlled by solvent for the divergent synthesis of two types 2,3-disubstituted skeletons has been developed. A variety 2-chromonyl-3-hydrazono-chromones and 2-alkoxy-3-hydrazono-chromones were constructed efficiently from readily available
An oxidative free-radical C(sp2)–H bond chlorination strategy of enaminones has been developed by using LiCl as a chlorinating reagent and K2S2O8 an oxidant. This transformation provides new straightforward synthetic methodology to afford highly functionalized α-chlorinated with Z-configuration in good excellent yields.
Abstract A novel approach to the study of binding thermodynamics and kinetics carbohydrate-protein interactions on unfixed cancer cell surfaces using a quartz crystal microbalance (QCM) biosensor was developed, in which events take place at surface, more closely mimicking biologically relevant environment. In this study, colon adenocarcinoma cells (KM-12) ovary (SKOV-3) grew optimized polystyrene-coated chip without fixation. The association dissociation between surface carbohydrates range...
The likelihood that a host will be susceptible to infection is influenced by the interaction of diverse biotic and abiotic factors. As result, substantial experimental replication scalability are required identify contributions interactions between host, environment, factors such as microbiome. For example, pathogen success known vary genotype, bacterial strain identity dose, dose. Elucidating these in vivo has been challenging because testing combinations variables quickly becomes...
A novel, eco-friendly, and efficient method for constructing 2,3-disubstituted chromone skeletons from readily available water, o-hydroxyaryl enaminones (o-HPEs), aryldiazonium salts has been developed under mild reaction conditions. This α,β-C(sp2)–H bond difunctionalization/chromone annulation strategy is achieved by building two C(sp3)–O bonds a C(sp2)-N bond, which provides practical pathway the preparation of 2-hydroxy-3-hydrazono-chromones in moderate to excellent yields, enabling...
Oral squamous cell carcinoma (OSCC) is the most common malignancy of head and neck; however, efficacy existing treatment limited new effective strategies need to be explored. Our previous work demonstrates that isoguanosine (isoG) a promising nucleoside molecule with superior self-assembly capability significant anti-OSCC potential. However, antitumor mechanism isoG remains unclear. In this study, we reveal antiproliferative effect mediated by its cellular metabolite, 5′-monophosphate...
Cervical cancer significantly affects women's health, while current preoperative imaging methods for predicting lymph node status are suboptimal. This study aims to evaluate the predictive value of CT attenuation (Hounsfield units) metastasis (LNM) in cervical patients and develop a nomogram integrates clinical features improve accuracy assessment. A retrospective analysis was conducted on 132 treated at Second Affiliated Hospital Dalian Medical University from January 2021 August 2024. The...
Computerized adaptive testing(CAT) is a crucial task in computer-aided education, which aims to adaptively select suitable question diagnose examinees' ability status. Existing CAT approaches enhance selection performance by exploring examinee-question(E-Q) relation. These either exclusively utilize explicit E-Q For instance, policy-based determine based on predefined criteria. While effective adapting changes banks, these methods often entail significant computational costs searching for...
Cognitive diagnosis is a key task in computer-aided education, aimed at assessing students' proficiency specific knowledge concepts based on their responses to exercises. However, existing cognitive models often overlook anomalies students and For instance, some might incorrectly response exercises despite having strong grasp of the concept, or they correctly lack understanding. Such subtle can adversely affect diagnostic results models. To address these anomalies, we conduct qualitative...
Abstract For optimal growth and development, hosts depend on their ability to promote healthy symbiotic interactions while restricting pathogen growth. To ask whether can distinguish phylogenetically similar pathogens beneficial bacteria, we used two closely related plant-associated strains of Pseudomonas fluorescens where one is the other exhibits toxin-dependent virulence. We show that co-exist in vitro , outcompetes planta . Using several readouts for plant innate immunity, found...
ABSTRACT While microbiomes provide diverse benefits for their host, they are notoriously variable in structure and function. As a result, substantial experimental replication scalability required to identify the contributions of interactions between microbiota, host environment. Here, we describe novel high throughput plant growth system (MYCroplanters) test how multiple pathogen variables predict health. Using an Arabidopsis- Pseudomonas host-microbiome-pathogen model, found that genotype...
An unprecedented base-controlled selective skeletal rearrangement reaction of hexahydro-4
A practical, effective, and regioselective palladium-catalyzed ring opening/[4+2] annulation of enaminones with cyclopropenones for the controllable synthesis highly substituted γ-butenolides γ-lactams has been described. This method first time reports regio-selective reaction on carbon amine groups enaminone structure. is characterized by its wide substrate scope, good functional group compatibility, moderate to yields, scale-up synthesis, versatile transformations, providing a general...
In new-tier cities with rapid urbanization, the reorganization of urban spatial functions and development road networks have brought novel challenges to traffic congestion control. Urban land use patterns a significant correlation congestion. However, whether how close roads affect is less be discussed. This article investigated relationship between trunk network in new tier Xi’an, China. We adopted DBSCAN algorithm cluster POIs mixed POI clusters label socio-economic roads. found...