A5006124860- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Particle Accelerators and Free-Electron Lasers
- Oxidative Organic Chemistry Reactions
- Terahertz technology and applications
- Gyrotron and Vacuum Electronics Research
- Synthesis and Characterization of Pyrroles
- Cyclopropane Reaction Mechanisms
- Catalytic Alkyne Reactions
- Synthesis and Biological Evaluation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Salivary Gland Disorders and Functions
- Optical Imaging and Spectroscopy Techniques
- Surface Modification and Superhydrophobicity
- Brain Tumor Detection and Classification
- Mineral Processing and Grinding
- Synthesis and Reactivity of Heterocycles
- Advanced Neural Network Applications
- Advanced Measurement and Detection Methods
- Radical Photochemical Reactions
- Ferroptosis and cancer prognosis
- Chemical Synthesis and Analysis
- Sulfur-Based Synthesis Techniques
Guangzhou Medical University
2024
Tsinghua University
2022-2024
Kunming University of Science and Technology
2022-2023
Hubei Polytechnic University
2023
Wuhan University of Science and Technology
2023
University of Copenhagen
2022
Xi’an Jiaotong-Liverpool University
2022
Hvidovre Hospital
2022
Copenhagen University Hospital
2022
Nanjing Agricultural University
2021
In recent years, artificial intelligence (AI) has been under rapid development, applied in various areas. Among a vast number of neural network (NN) models, the convolutional (CNN) mainstream status application such as image and sound recognition machine decision. The convolution operation is most complex requires acceleration. A practical method to optimize architecture deep learning processor (DLP). traditional CPU lacks parallelism memory bandwidth not suitable for CNN operations. Current...
An unprecedented protocol for a Rh(III)-catalyzed [3 + 2] annulation from simple and readily available enaminones iodonium ylides has been developed. The novel strategy allows access to new class of structurally diverse tetrahydro-indolones with high efficiency broad substrate scope. In addition, this transformation represents the first example selective alkenyl C–H bond functionalization enaminones. Finally, potential applications are demonstrated through gram-scale reaction late-stage modification.
A novel Rh(III)-catalyzed cascade alkenyl C-H activation/[3 + 2] annulation/pinacol rearrangement reaction of enaminones with iodonium ylides has been developed. This methodology provides a new and straightforward synthetic strategy to afford highly functionalized 2-spirocyclo-pyrrol-3-ones in satisfactory yield from readily available starting materials under mild conditions. Moreover, gram-scale reactions further derivatization experiments are implemented demonstrate the potential utility...
Highly functionalized 3a,7a-dihydroxy hexahydro-4 H -indol-4-ones were efficiently synthesized via a Ru( iii )-catalyzed alkenyl C(sp 2 )–H bond functionalization/[3 + 2] annulation reaction between readily available enaminones and iodonium ylides.
Using benzylamines as the C4 source of 1,4-dihydropyridines (1,4-DHPs), a Cu-catalyzed oxidative [1+2+1+2] cascade cyclization for synthesis 1,4-DHPs was firstly developed. A broad range easily available N,N-dimethyl enaminones and are employed smoothly to provide diverse with high efficiency. This method is performed by one-pot C(sp3 )-H bond functionalization/C(sp3 )-N cleavage/cyclization strategy form simultaneously two )-C(sp2 ) bonds, C(sp2 1,4-DHP ring.
Abstract A silver‐catalyzed protocol for the synthesis of 3‐(1 H ‐isochromen)‐chromones is described. The method involves an initial 6‐endo‐dig cyclization o ‐alkynylbenzaldehydes and domino C−H alkylation chromone annulation ‐hydroxyarylenaminones, which enables installation 1 ‐isochromen in a single structure. This synthetic strategy advantageous excellent regioselectivity, step economy, concise one‐pot methodology, gram‐scale synthesis, as well high bond‐forming efficiency. magnified image
A wide variety of isocoumarin derivatives are easily constructed via a Rh( iii )-catalyzed C–H bond activation/annulation cascade reaction.
Highly functionalized benzodiazepine skeletons were efficiently synthesized via a Rh( iii )-catalyzed selective mono- and dual-C–H bond functionalization/cyclization reaction between readily available 1-aryl-5-aminopyrazoles iodonium ylides under.
The evaluation of endoscopic disease severity is a crucial component in managing patients with ulcerative colitis (UC). However, assessment suffers from substantial intraobserver and interobserver variations, limiting the reliability individual assessments. Therefore, we aimed to develop deep learning model capable distinguishing active healed mucosa differentiating between different degrees.One thousand four hundred eighty-four unique images 467 were extracted for classification. Two...
Abstract An oxidative [3+2+1] cyclization of enaminones and N ‐alkenyl‐2‐pyrrolidinone is described for the synthesis 4‐alkylated 1,4‐dihydropyridines (1,4‐DHPs). By using terminal olefin as C4 source 1,4‐DHP skeleton, this synthetic strategy provides a series 1,4‐DHPs through 1,1‐difunctionalization/cyclization process. In protocol, two C( sp 3 )−C( 2 ) bonds )−N bond are simultaneously formed, hydrogen on newly formed methyl group skeleton confirmed possible mechanism proposed. magnified image
Syntheses of highly functionalized 4-alkylated 1,4-dihydropyridines (1,4-DHPs) from cyclic ethers and enaminones via iron(II)-mediated oxidative free radical cascade C(sp3)-H bond functionalization/C(sp3)-O cleavage/cyclization reaction have been first developed. This novel synthetic strategy offers an alternative method for the construction 1,4-DHPs by using esters as C4 sources, well expands application in heterocycle synthesis.
In this paper, the interaction mechanism between solid–liquid–gas interface phenomenon caused by nanostructure and surface wettability boiling heat transfer is described, theory of single wettable mixed proposed. Through molecular dynamics simulation, thermodynamic model nanostructures established. The are set as four rectangular lattice structures with a height 18 Å. solid atoms platinum atoms, liquid argon atoms. simulation results show that increase hydrophilicity nanostructures, fluid...
A novel and efficient technique has been designed for the creation of oxygen vacancies on La2Ti2O7 (LTO) nanosheets. This is achieved via a controlled solid-state reaction between NaBH4 LTO Transmission electron microscopy (TEM) analyses expose that these processed specimens possess unique crystalline core/amorphous shell structure, represented as La2Ti2O7@La2Ti2O7-x. According to X-ray photoelectron spectroscopy (XPS) observations, there notable correlation time, temperature, concentration...
An Fe-mediated four-component reaction of enaminones, anhydrides and tetrahydrofuran through a cascade [1 + 2 3]-cyclization/esterification process is presented. This protocol provides new effective method to construct 4-alkylated 1,4-dihydropyridines with an ester fragment. Cyclic ether employed as the C4 source for first time.
A metal-free regioselective oxidative annulation reaction of readily available 2,4-pentanediones with primary amines has been described. This protocol provides a divergent strategy for the incorporation various radical donors into 5-alkylidene 3-pyrrolin-2-one skeletons, producing variety thiionized-, selenolized-, and alkylated derivatives. Moreover, diverse synthetic transformations products were also investigated.
<title>Abstract</title> High-intensity and widely tunable sources in the terahertz (THz) frequency range are highly desirable for both fundamental applied researches. Free electron lasers (FELs) coupling between a relativistic beam copropagating electromagnetic wave an undulator can generate intense THz light. However, most FEL facilities still working with relatively long low-peak-current beam, limiting emission efficiency pulse energy. Here, we demonstrate superradiant by pre-modulating...
In coherent radiation of an ensemble electrons, field from electrons resonantly drives the other inside to produce stimulated emission. The reaction force on accounting for this loss is classically described by Lienard-Wiechert potential. Despite its being foundation beam physics decades, we show that using "acceleration field'' in potential describe radiative interactions leads divergences due implicit dependence instantaneous interactions. Here, propose alternative theory electromagnetic...
In coherent radiation of an ensemble electrons, the field from electrons resonantly drives other inside to produce stimulated emission. The reaction force on accounting for this loss is classically described by Liénard-Wiechert potential. Despite its being foundation beam physics decades, we show that using "acceleration field" in potential describe radiative interactions leads divergences due implicit dependence instantaneous interactions. Here, propose alternative theory electromagnetic...
Pump-probe experiments using x-ray pulses or MeV ultrafast electrons as probes are important for studying dynamic processes at the atomic level. Increasing demand is being focused on ultrashort and electron to research down a few femtoseconds. Due limitation of space charge force, only low bunches with critical synchronization can achieve such short pulses. A high-precision beam arrival-time monitor especially important. In this paper, ${Q}_{l}$ cavity high sensitivity designed measure...