A5072653042- Peroxisome Proliferator-Activated Receptors
- Phytochemistry and Biological Activities
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Proteoglycans and glycosaminoglycans research
- Diabetes Treatment and Management
- Phytochemicals and Antioxidant Activities
- Glycosylation and Glycoproteins Research
- Microbial Metabolites in Food Biotechnology
- Drug Transport and Resistance Mechanisms
- Pancreatic function and diabetes
- Radioactive element chemistry and processing
- Seed and Plant Biochemistry
- Receptor Mechanisms and Signaling
- Protein Interaction Studies and Fluorescence Analysis
- Osteoarthritis Treatment and Mechanisms
- Medicinal Plant Pharmacodynamics Research
- Phytochemical Studies and Bioactivities
- Protein purification and stability
- Polysaccharides and Plant Cell Walls
- Phytoestrogen effects and research
- Bioactive Natural Diterpenoids Research
- Covalent Organic Framework Applications
- Diet, Metabolism, and Disease
Guangdong Pharmaceutical University
2019-2025
Jining Medical University
2016-2024
Chengdu University of Traditional Chinese Medicine
2024
Beijing Institute of Petrochemical Technology
2023
China Pharmaceutical University
2023
East China University of Technology
2022-2023
Jiangmen Central Hospital
2022
First Affiliated Hospital of Guangdong Pharmaceutical University
2021
Shenyang Pharmaceutical University
2017-2020
Shandong Normal University
2018
Metabolic dysfunction-associated steatohepatitis (MASH) is a complex disease driven by diverse metabolic and inflammatory pathways. Farnesoid X receptor (FXR) promising target for MASH due to its role in bile acid lipid metabolism, while HSD17B13 regulates liver droplet homeostasis. However, the existing inhibitors have several druglike property challenges common phenolic structure, key pharmacophore inhibitor. In this study, two-round high-throughput screening was performed identify FXR...
Chromatographic purification of the roots Daphne genkwa led to 11 new guaiane-type sesquiterpenoids (1–11), named genkwanoids A–K, and six known analogues (12–17). A comprehensive set spectroscopic methods including IR, UV, HRESIMS, 1D/2D NMR were used elucidate structures relative configurations 1–11. The absolute determined by optical rotation calculations modified Mosher's method. possible biosynthetic pathways for 1–11 are proposed. Furthermore, neuroprotective effects 1–17 on...
The prevalence of nonalcoholic steatohepatitis (NASH) is increasing rapidly worldwide, and NASH has become a serious problem for human health. Recently, the selective activation intestinal farnesoid X receptor (FXR) was considered as more promising strategy treatment with lesser side effects due to reduced systemic exposure. Moreover, inhibition fatty acid binding protein 1 (FABP1) alleviated obesity by reducing dietary uptake. In this study, first-in-class restricted FXR FABP1 dual-target...
Tartary buckwheat is an alternative cereal crop. This study sought to establish the mechanisms whereby tartary root polysaccharide (TBRP-1) treatment can alleviate diabetes mellitus. TBRP-1 was extracted and purified by hot water gel permeation column chromatography. Its structure determined Fourier transform-infrared spectroscopy (FT-IR), monosaccharide analysis, nuclear magnetic resonance (NMR) spectroscopy. composed of fucose, arabinose, rhamnose, galactose, glucose, xylose, mannose,...
Untargeted delivery as well low efficacy are two main obstacles for effective breast cancer therapy. Here in this study, we surface modified silica nanoparticles (SLN) with Trastuzumab (Tra) to construct a tumor-targeting carrier (Tra-SLN) specific drug human epidermal growth factor receptor 2 (HER2) overexpressing cells. In addition, Tra-SLN could also loaded broad-spectrum anticancer doxorubicin (DOX) finally system (DDS) capable of co-delivering Tra and DOX (Tra-SLN/DOX). Our results...
Background and Purpose The free fatty acid receptor 1 (FFAR1) plays an important role in glucose‐stimulated insulin secretion making it attractive anti‐diabetic target. This study characterizes the pharmacological profile of HWL‐088 (2‐(2‐fluoro‐4‐((2′‐methyl‐[1,1′‐ biphenyl]‐3‐yl)methoxy)phenoxy)acetic acid), a novel highly potent FFAR1 agonist vitro vivo. Moreover, we investigated long‐term effects alone combination with metformin diabetic mice. Experimental Approach In on PPARα/γ/δ were...
To investigate the mechanisms underlying neuroprotective effect of L-serine, permanent focal cerebral ischemia was induced by occlusion middle artery while monitoring blood flow (CBF). Rats were divided into control and L-serine-treated groups after occlusion. The neurological deficit score brain infarct volume assessed. Nissl staining used to quantify cortical injury. L-serine D-serine levels in ischemic cortex analyzed with high performance liquid chromatography. We found that treatment:...
The present study was conducted to clarify whether treatment with L-serine can improve the brain repair and neurorestoration of rats after permanent middle cerebral artery occlusion (pMCAO). After pMCAO, neurological functions, lesion volume, cortical injury were determined. GDNF, NGF, NCAM L1, tenascin-C, Nogo-A levels measured. Proliferation differentiation neural stem cells (NSCs) proliferation microvessels in ischemic boundary zone cortex evaluated. Treatment (168 mg/kg body weight,...