A5010599035- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Diagnosis and Treatment
- Abdominal vascular conditions and treatments
- Hemodynamic Monitoring and Therapy
- Acute Ischemic Stroke Management
- Advanced X-ray and CT Imaging
- Peptidase Inhibition and Analysis
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Ischemia and Reperfusion
- Cell Adhesion Molecules Research
- Sepsis Diagnosis and Treatment
- Radiation Dose and Imaging
- Abdominal Surgery and Complications
- Bartonella species infections research
- Gallbladder and Bile Duct Disorders
- Lymphoma Diagnosis and Treatment
- Connexins and lens biology
- PARP inhibition in cancer therapy
- Calpain Protease Function and Regulation
- Lung Cancer Research Studies
- Cardiac Valve Diseases and Treatments
- MRI in cancer diagnosis
- Radioactive element chemistry and processing
- Ultrasound in Clinical Applications
TU Dresden
2019-2024
University Hospital Carl Gustav Carus
2020-2024
Deutschen Konsortium für Translationale Krebsforschung
2022
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2020-2021
Krankenhaus Bethanien
2020
OncoRay
2020
Helmholtz-Zentrum Dresden-Rossendorf
2020
The analysis aimed to compare the radiotracers [68Ga]-Ga-PSMA-11 and [18F]-F-PSMA-1007 intraindividually in terms of malignant lesions, mi(molecular-imaging)TNM staging presumable unspecific lesions retrospectively as used routine clinical practice.A retrospective 46 prostate cancer patients (median age: 71 years) who underwent consecutive [68Ga]-Ga-PSMA-11- [18F]-F-PSMA-1007-PET/CT or PET/MRI within a mean 12 ± 8.0 days was performed. MiTNM performed both studies by two nuclear medicine...
68 Ga-Trivehexin is an investigative PET radiopharmaceutical targeting the "cancer integrin" αvβ6, a tumor cell biomarker which highly expressed by various carcinomas [1].Feasibility of αvβ6-integrin for cancer imaging has been demonstrated in preclinical and first clinical
A 28-year-old man underwent FDG-PET/CT for Hodgkin lymphoma restaging after 6 cycles of BEACOPP chemotherapy. He had recently been diagnosed with herpes zoster, treated antivirals, presenting a painful rash on the right lower flank. The FDG PET scan revealed high focal uptake in 11th spinal nerve ganglion and moderate diffuse area. follow-up 10 weeks showed complete regression both findings. To best our knowledge, this is first reported case marked FDG-avid indicating active ganglioneuritis...
Background/Objectives: Radiological imaging is crucial in intensive care settings, particularly for the differential diagnosis of fever and sepsis. Computed tomography (CT) preferred method detecting infectious foci critically ill ICU patients. Methods: This study prospectively analyzed non-ECG-gated chest abdominal CT scans from patients to assess CT’s diagnostic utility. Data prior modalities (CT, radiography, MRI, ultrasound), microbiological assays (blood cultures, bronchoalveolar...
Abstract Purpose To investigate the outcome of local intra-arterial papaverine infusion therapy in patients with non-occlusive mesenteric ischemia (NOMI), and factors influencing survival, comparison a conservative approach. Methods From 2013 to 2019 , NOMI confirmed by imaging were included retrospective two-center study. According different in-house standard procedures, treated each center either conservatively or interventionally standardized into splanchnic arteries. Thirty-day mortality...
Background To assess whether thrombus surface morphology has an impact on first pass reperfusion in contact aspiration (CA) and stent retriever (SR) thrombectomy. Methods From January 2016 to December 2018, consecutive stroke patients with occlusion of the middle cerebral artery thrombectomy (CA or SR) were examined this retrospective study. We assessed patients’ characteristics, procedural data clinical outcome. Thrombus pretreatment digital subtraction angiography (DSA) was categorized...
The study aimed to evaluate the effect of androgen deprivation therapy (ADT) on PSMA imaging and its correlation PSA concentration by comparing qualitative quantitative parameters: SUVmax, SUVmean, PSMA-derived tumor volume (PSMA-TV), total lesion (TL-PSMA) molecular (mi)PSMA score.Retrospective analysis 21 therapy-naïve patients with oligometastatic prostate cancer (median age 70 years) who underwent either [68Ga]Ga-PSMA-11-PET/CT or -PET/MRI before initiation (T1) as well during ADT (T2)....
Polymethylmethacrylate (PMMA) removal during septic total joint arthroplasty revision is associated with a high fracture and perforation risk. Ultrasonic cement considered bone-preserving technique. Currently, there still lack of sound data on efficacy as it difficult to detect smaller residues reasonable technical effort. However, incomplete the risk biofilm coverage residue. Therefore, study aimed investigate efficiency ultrasonic-based PMMA in human cadaver model. The femoral components...
Purpose 68 Ga-Trivehexin is a PET tracer targeting αvβ6-integrin, transmembrane receptor that frequently expressed by pancreatic cancer cells. This study aimed to determine the biokinetics, image contrast, and acquisition parameters for imaging in cancers. Methods 44 patients with underwent Trivehexin PET/CT between June 2021 November 2022 (EK-242052023). Biokinetics -distribution were extracted. Previous follow-up imaging, histological findings used as reference standards. A one-way ANOVA...
Based on the results of NETTER-1 trial, peptide receptor radionuclide therapy with Lutetium-177 (177Lu) - DOTATATE is authorized for treatment neuroendocrine tumors (NET) grade 1 (G1) and 2 (G2) intestine. After failure 177Lu-DOTATATE therapy, targeted alpha-particle (TAT) may be a possible option. Here, we present patient cancer unknown primary NET G2 later G3. The was referred to our hospital urosepsis due second-degree urinary retention. stent insertion, contrast-enhanced computed...
Background: Peri-interventional myocardial injury occurs frequently during transcatheter aortic valve implantation (TAVI). We assessed the effect of remote ischemic preconditioning (RIPC) on injury, acute kidney (AKIN) and 6-month mortality in patients undergoing TAVI. Methods: performed a prospective single-center controlled trial. Sixty-six treated with RIPC prior to TAVI were enrolled study matched control group by propensity-score. was applied upper extremity using conventional...
Calpains are calcium activated cysteine proteases that play a pivotal role in the pathophysiology of cardiac remodeling. Here, we performed left anterior descending coronary artery ligation rats as model for ischemic systolic heart failure and examined time- region-specific regulation calpain-1 calpain-2 ventricular myocardium. Following wall myocardial infarction, calpain activity was significantly increased restricted to area at days 1, 5 14. No changes neither time point were detected...
Accurate detection and segmentation of the intraprostatic gross tumor volume (GTV) is pivotal for radiotherapy (RT) in primary prostate cancer (PCa) since it influences focal therapy target volumes patients' cT stage. The study aimed to compare performance multiparametric resonance imaging (mpMRI) with [18F] PSMA-1007 positron emission tomography (PET) GTV as well delineation evaluate their respective influence on RT concepts. In total, 93 patients from two German University Hospitals...
Abstract Purpose To investigate whether adrenal gland radiodensities alone or set in relation to either the inferior vena cava (IVC) spleen can predict hospital mortality intensive care unit patients. Methods One hundred thirty-three patients (90 males, age: 66.3 ± 14.5 years) with an acute clinical deterioration were included this retrospective analysis. CT attenuation (Hounsfield units) of glands, IVC, and was evaluated by 2 radiologists separately. Adrenal-to-IVC adrenal-to-spleen ratios...
Systemic inflammation can occur after transcatheter aortic valve replacement (TAVR) and correlates with adverse outcome. The impact of remote ischemic preconditioning (RIPC) on TAVR associated systemic is unknown was focus this study.We performed a prospective controlled trial at single center included 66 patients treated prior to TAVR, who were matched control group by propensity score. RIPC applied the upper extremity using conventional tourniquet. Definition based leucocyte count,...
In critically ill ICU patients, initial results showed that opposite enhancement of the adrenal glands (↑) and spleen (↓) on portal venous CT scans was associated with increased mortality over next days to a month, short-term being best predicted. The study aimed validate adrenal-to-spleen ratio determined in pilot concerning prediction.371 203 patients (127 men, age: 68.1 ± 14.4 years) were included retrospective analysis. Region-of-interest (ROI)-based Hounsfield units their density...
Objective: To assess whether angiographic thrombus surface phenotype has an impact on efficacy of contact aspiration (CA) thrombectomy in patients with basilar artery occlusion (BAO). Methods: From January 2016 to December 2019, consecutive stroke a BAO and first-line CA were analyzed this retrospective study. We assessed baseline imaging characteristics treatment clinical outcomes. rated pre-treatment digital subtraction angiography three-reader-consensus setting. Primary outcome was...
Zielsetzung Bei einer ausgeprägten Hypotonie im Rahmen eines Schocks kommt es zu Minderperfusion abdomineller Organe, insbesondere der Milz. Diese Studie evaluiert die Milz/Aorta Dichterelation in kontrastverstärkten Computertomografie (CT) als Prädiktor für Mortalität vital gefährdeter Patienten.