A5103272912- Thyroid Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
- Prostate Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Thyroid and Parathyroid Surgery
- Cardiac Imaging and Diagnostics
- Radiation Dose and Imaging
- Advanced X-ray and CT Imaging
- Cardiac electrophysiology and arrhythmias
- Thyroid Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Urologic and reproductive health conditions
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging and Pathology Studies
- Advanced Radiotherapy Techniques
- Head and Neck Anomalies
- Cardiac Arrhythmias and Treatments
- Cardiac tumors and thrombi
- Cardiovascular Effects of Exercise
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Neuroinflammation and Neurodegeneration Mechanisms
European University Cyprus
2021-2024
University of Cyprus
2021
University Hospital Münster
2010-2021
Limassol General Hospital
2018-2021
European Association of Nuclear Medicine
2021
University of Münster
2012-2016
Deutsche Forschungsgemeinschaft
2014
Klinik und Poliklinik für Nuklearmedizin
2010-2014
University of Duisburg-Essen
2013
Stroke is the most common cause of death and disability from neurologic disease in humans. Activation microglia matrix metalloproteinases (MMPs) involved positively negatively affecting stroke outcome. Novel, noninvasive, multimodal imaging methods visualizing microglial MMP alterations were employed. The spatio-temporal dynamics these parameters studied relation to blood flow changes. Micro positron emission tomography (μPET) using [ 18 F]BR-351 showed activity within first days after...
A 65-year-old man with disseminated bone metastases of prostate cancer was referred for Ga-PSMA-HBED-CC-PET/CT (short PSMA-PET/CT) to exclude visceral before treatment Ra-dichloride. Apart from metastases, PSMA-PET/CT revealed a focal cerebral tracer uptake in the right frontal lobe highly suspicious spread. According patient history, infarction occurred 14 days PSMA imaging corresponding localization confirmed by MRI scanning. This case demonstrates possibility false-positive finding...
Most patients with thyroid nodules and cancer (TC) referred for diagnostic work-up treatment are not considered at higher risk of infection from SARS-CoV-2 compared to the general population. On other hand, healthcare resources should be spared maximum extent possible during a pandemic. Indeed, while very common, only small percentage cancerous and, in turn, most cancers indolent nature. Accordingly, nodules, surgery either benign or malignant radioiodine differentiated may safely postponed...
With the increased use of focal radiation dose escalation for primary prostate cancer (PCa), accurate delineation gross tumor volume (GTV) in prostate-specific membrane antigen PET (PSMA-PET) becomes crucial. Manual approaches are time-consuming and observer dependent. The purpose this study was to create a deep learning model intraprostatic GTV PSMA-PET.
Fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) was reported to outperform fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT in thyroid cancer heterogenous patient collectives. This interim analysis of a prospective study aims determine whether 18F-FAPI-74 is superior 18F-FDG the distinct subgroup radioactive-iodine (RAI)-refractory differentiated (DTC). Ten patients with recurrent DTC, detected by elevated thyroglobulin, negative...
The optimal management for early recurrent prostate cancer following radical prostatectomy (RP) in patients with negative prostate-specific membrane antigen positron-emission tomography (PSMA-PET) scan is an ongoing subject of debate. aim this study was to evaluate the outcome salvage radiotherapy (SRT) biochemical recurrence PSMA PET finding.
Abstract Purpose The purpose of this retrospective, multicenter study was to assess efficacy PSMA-PET/CT-guided salvage radiotherapy (sRT) in patients with recurrent or persistent PSA after primary surgery and levels < 0.2 ng/ml. Methods included from a pooled cohort ( n = 1223) 11 centers 6 countries. Patients > ng/ml prior sRT without the prostatic fossa were excluded. endpoint biochemical recurrence-free survival (BRFS) BR defined as nadir + Cox regression analysis performed impact...
Abstract Purpose Convolutional Neural Networks (CNNs) have emerged as transformative tools in the field of radiation oncology, significantly advancing precision contouring practices. However, adaptability these algorithms across diverse scanners, institutions, and imaging protocols remains a considerable obstacle. This study aims to investigate effects incorporating institution-specific datasets into training regimen CNNs assess their generalization ability real-world clinical environments....
Freehand single photon emission computed tomography (fSPECT) is a three-dimensional (3-D) tomographic imaging modality based on data acquisition with handheld detector that moved freely, in contrast to conventional, gantry-mounted gamma camera systems. In this pilot study, we evaluated the feasibility of fSPECT for intraoperative 3-D mapping patients parathyroid adenomas. Three (range 30 45 years) diagnosed hyperparathyroidism (one primary and two tertiary) underwent scintigraphy...
Parkinson's disease is a slowly progressing neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra (SN), leading to severe impairment motor and non-motor functions. Endogenous subventricular zone (SVZ) neural stem cells constantly give birth new that might serve as possible source for regeneration adult brain. However, neurodegeneration accompanied neuroinflammation dopamine depletion, potentially compromising regeneration. We therefore employed vivo...
Circumferential pulmonary vein isolation (PVI) is the cornerstone of current state-of-the-art management atrial fibrillation (AF). However, precise mechanisms behind AF relapses post PVI are still unknown. Since activity autonomous nervous system crucial in triggering paroxysmal AF, we hypothesized that associated with changes cardiac sympathetic activity. Sixteen patients underwent iodine-123-meta-iodobenzylguanidine (123I-mIBG) planar imaging and single-photon emission computed tomography...
Background and Objectives To investigate if patients with thyroid carcinoma having N1a disease are at the same risk N1b using collective of well-defined European prospective Multicentre Study Differentiated Thyroid Cancer (MSDS). Methods Overall (OS) event free survival (EFS) were calculated. Cox multivariable regression analysis was performed in order to calculate Hazard ratios (HR). Results EFS significantly decreased only metastasis as compared N0 became worse when concomitantly affected....
Summary Objective The seventh edition of the American Joint Committee on Cancer ( AJCC ) has more detailed staging categories for differentiated thyroid cancer DTC than fifth edition. aim was to compare potential alterations in disease‐specific DSS ), event‐free EFS and overall survival OS after reclassification from Methods Data 2460 patients with referred our centre were reclassified . , calculated using Kaplan‐Meier method compared by log‐rank test. relative abilities each predict...
The "back-translation" of clinically available protocols to measure myocardial perfusion preclinical imaging in mouse models human disease is attractive for basic biomedical research. With respect single-photon emission computed tomography (SPECT) approaches, clinical are established with different 99mTc-labeled tracers; however, studies evaluating and optimizing these tracers high-resolution pinhole SPECT mice lacking. This study aims at two (99mTc-sestamibi vs. 99mTc-Tetrofosmin) using...
Differentiated thyroid carcinomas (DTC) have an excellent prognosis, with 10-year overall survival rates over 90%. In addition, DTC patients benefit from their lifelong medical surveillance. The AIM of the study was to compare patients' that a matched general population.We analyzed 1497 consecutive DTC, who underwent radioiodine therapy in Münster, Germany, according international standards. We classified our current 7th edition UICC (Union Internationale Contre le Cancer) classification and...
Myocardial perfusion gated single photon emission computed tomography (SPECT) can be used for non-invasive detection of coronary artery stenosis and cardiac allograft vasculopathy (CAV), which is a crucial factor the long-term survival heart transplant (HTx) recipients. A frequently observed finding in myocardial imaging patients after HTx inhomogeneous perfusion. This not associated with epicardial CAV, but its prognostic relevance unclear so far. We therefore evaluated prognosis...
The aim of this study was to compare the overall survival a large, single-center cohort patients who had differentiated thyroid cancer (DTC) with that matched general population.We analyzed 2,428 consecutive DTC and underwent treatment from 1965 2013 at Department Nuclear Medicine, University Hospital Münster, Germany, according international standards. Patients were classified on basis current, seventh edition American Joint Committee Cancer/Union for International Cancer Control...