A5033302235- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Cardiac tumors and thrombi
- Medical Imaging and Pathology Studies
- Neuroblastoma Research and Treatments
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pituitary Gland Disorders and Treatments
- Amino Acid Enzymes and Metabolism
- Neuroscience and Neuropharmacology Research
- Hematological disorders and diagnostics
- Epilepsy research and treatment
- Cardiac Structural Anomalies and Repair
- Advanced MRI Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Advanced X-ray and CT Imaging
University Hospital Münster
2015-2024
SLK-Kliniken Heilbronn
2024
Klinik und Poliklinik für Nuklearmedizin
2010-2023
West Cancer Center
2020
West German Heart and Vascular Center Essen
2020
University of Duisburg-Essen
2013-2018
Essen University Hospital
2018
Klinikum Bremen-Mitte
2018
University of Münster
2008-2017
Creative Commons
2015
In the diagnostic algorithm of cardiac tumors, noninvasive determination malignancy and metastatic spread is major interest to stratify patients select monitor therapies. work-up, morphologic imaging modalities such as echocardiography or magnetic resonance tomography offer information on, for example, size, invasiveness, vascularization. However, preoperative assessment may be unsatisfactory. The aim this study was evaluate value <sup>18</sup>F-FDG PET incremental an optimized CT score in...
Purpose Interim positron emission tomography (PET) using the tracer, [18F]fluorodeoxyglucose, may predict outcomes in patients with aggressive non-Hodgkin lymphomas. We assessed whether PET can guide therapy who are treated cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). Patients Methods Newly diagnosed received two cycles of CHOP-plus rituximab (R-CHOP) CD20-positive lymphomas-followed by a scan that was evaluated ΔSUVmax method. PET-positive were randomly assigned to...
Despite progress in treatment of metastatic castration-resistant prostate cancer (mCRPC), new approaches are urgently needed. Recently theranostic concepts using radiolabeled ligands the prostate-specific membrane antigen (PSMA) have been developed for diagnostics and therapy patients with advanced mCRPC. The aim this study was to evaluate tumor response, adverse effects, survival undergoing radioligand Lu-PSMA-617.Fifty therapies Lu-PSMA-617 were performed 28 consecutive mCRPC exhausted...
We evaluated the diagnostic value and accuracy of prostate-specific membrane antigen (PSMA) PET for intraprostatic delineation prostate cancer before prostatectomy. <b>Methods:</b> identified 6 patients with biopsy-proven high-risk who were referred <sup>68</sup>Ga-PSMA PET/CT radical prostatectomy to rule out metastasis. After prostatectomy, a histologic map was reconstructed. The extent Gleason score each segment compared images resliced axis. Sensitivity, specificity, positive negative...
There is an increasing interest in local tumor ablative treatment modalities that induce immunogenic cell death and the generation of antitumor immune responses. We report six recurrent glioblastoma patients who were treated with intracavitary thermotherapy after coating resection cavity wall superparamagnetic iron oxide nanoparticles (“NanoPaste” technique). Patients underwent 1-h hyperthermia sessions alternating magnetic field and, if possible, received concurrent fractionated...
BACKGROUND: Approximately 20% of grade II and most III gliomas fluoresce after 5-aminolevulinic acid (5-ALA) application. Conversely, approximately 30% nonenhancing are actually high grade. OBJECTIVE: The aim this study was to identify preoperative factors (ie, age, enhancement, 18F-fluoroethyl tyrosine positron emission tomography [18F-FET PET] uptake ratios) for predicting fluorescence in without typical glioblastomas imaging features determine whether will allow prediction tumor or...
The introduction of ligands targeting prostate-specific membrane antigen (PSMA), especially 68Ga-PSMA-11, has changed the management patients with prostate cancer (PCa). 18F-Labelled can be produced in larger amounts and therefore improve availability for a group patients. aim this study was to evaluate diagnostic performance recently introduced 18F-PSMA-1007 recurrent PCa. This retrospective analysis included 100 consecutive biochemical relapse (mean age 68.75 ± 7.6 years) referred PSMA...
[177Lu]Lu-PSMA-617 (Lu-PSMA) radioligand therapy is an emerging treatment option for patients with end-stage prostate cancer. However, response to Lu-PSMA only achieved in approximately half of patients. It clinically important identify at risk poor outcome. Therefore, the aim this study was evaluate pretherapeutic PSMA PET derived total tumor volume and related metrics as prognosticators overall survival receiving therapy.A number 110 form Departments Nuclear Medicine Münster Essen were...
Rationale: PSMA-PET-CT enables measuring molecular expression of prostate-specific membrane antigen (PSMA) in vivo, which is the target molecule 177 Lu-PSMA-617 (Lu-PSMA) therapy.However, correlation PSMA and overall survival (OS) patients treated with Lu-PSMA therapy currently unclear; especially regard to coexistence high low expressing metastases.To this end, retrospective single arm study elucidates therapy.Additionally, PET based criteria define were explored.Methods: Eighty-five...
The fibroblast activation protein (FAP) is an emerging target for molecular imaging and therapy in cancer. OncoFAP a novel small organic ligand FAP with very high affinity. In this translational study, we establish [68Ga]Ga-OncoFAP-DOTAGA (68Ga-OncoFAP) radiolabeling, benchmark its properties preclinical imaging, evaluate application clinical PET scanning.68Ga-OncoFAP was synthesized cassette-based fully automated labeling module. Lipophilicity, affinity, serum stability of 68Ga-OncoFAP were...
Abstract: Diagnosis of chronic inflammatory bowel disease (IBD) in children requires noninvasive, atraumatic diagnostic tools that depict localization and acuity inflammation yield only a low radiation dose. This retrospective analysis evaluates the potential FDG‐PET. Twenty‐six consecutive FDG‐PET scans 23 patients (age: 2–16, years, 14 M, 9 F) with suspected IBD were analyzed this study. Results compared to endoscopic, histologic, abdominal ultrasound (US) finding. In these examinations,...
BackgroundDifferentiation between inflammatory and fibromatous strictures in Crohn's disease (CD) is difficult but crucial for therapeutic decisions. The aim of this study was to assess the best noninvasive imaging method detection differentiation stenoses CD comparison endoscopic histologic evaluation.
A low mutation rate seems to be a general feature of pediatric cancers, in particular oncofusion gene-driven tumors. Genetically, Ewing sarcoma is defined by balanced chromosomal EWS/ETS translocations, which give rise oncogenic chimeric proteins (EWS-ETS). Other contributing somatic mutations involved disease development have only been observed at frequency.Tumor samples 116 patients were analyzed here. Whole-genome sequencing was performed on two with normal, primary, and relapsed tissue....
The purpose of this study was to identify previous treatments and biomarker profile features that prognosticate overall survival (OS) in patients with mCRPC receiving 177 Lu-PSMA-617.Methods: 109 treated a median 3 cycles Lu-PSMA-617 were included.Data analyzed according OS as well PSA response patterns regard prior therapies, laboratory biomarkers metastatic extent univariate multivariate Cox's proportional hazards models.PSA decline assessed using the lowest levels after first cycle...
Abstract Background/aim: This is the first investigation of central processing itch in brain 8 subjects with atopic dermatitis (AD) comparison to 6 healthy controls (HC), comparing histamine‐induced related activations frontal, prefrontal, parietal, cingulate cortex, thalamus, basal ganglia and cerebellum. Methods: We employed 1% histamine‐dihydrochlorid‐iontophoresis left hand, recorded H 2 15 O‐PET‐scans perception intensity on a numeric rating scale. Results: There was no significant...