A5015300055- Advanced Radiotherapy Techniques
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Lipoproteins and Cardiovascular Health
- Prostate Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Allergic Rhinitis and Sensitization
- Head and Neck Cancer Studies
- Food Allergy and Anaphylaxis Research
- Adipokines, Inflammation, and Metabolic Diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Prostate Cancer Treatment and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Adipose Tissue and Metabolism
- Medical Imaging Techniques and Applications
- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Health Promotion and Cardiovascular Prevention
- Entomological Studies and Ecology
European University Cyprus
2021-2024
University of Cyprus
2021-2024
Limassol General Hospital
2018-2023
Stallergenes Greer (France)
2022
AC Camargo Hospital
2018
Sana Klinikum Offenbach
2017
Otto-von-Guericke University Magdeburg
2017
Takeda (Germany)
2006-2010
Takeda (Japan)
2008-2009
Institut für Klinische Forschung und Entwicklung
2007
Auto-segmentation with artificial intelligence (AI) offers an opportunity to reduce inter- and intra-observer variability in contouring, improve the quality of contours, as well time taken conduct this manual task. In work we benchmark AI auto-segmentation contours produced by five commercial vendors against a common dataset.The organ at risk (OAR) generated solutions (Mirada (Mir), MVision (MV), Radformation (Rad), RayStation (Ray) TheraPanacea (Ther)) were compared manually-drawn expert...
Abstract Purpose The purpose of this retrospective, multicenter study was to assess efficacy PSMA-PET/CT-guided salvage radiotherapy (sRT) in patients with recurrent or persistent PSA after primary surgery and levels < 0.2 ng/ml. Methods included from a pooled cohort ( n = 1223) 11 centers 6 countries. Patients > ng/ml prior sRT without the prostatic fossa were excluded. endpoint biochemical recurrence-free survival (BRFS) BR defined as nadir + Cox regression analysis performed impact...
Objective: The aim of the study was to analyze effect pioglitazone (PIO) and simvastatin (SIMVA) on adiponectin visfatin concentrations in nondiabetic patients with metabolic syndrome increased risk for cardiovascular complications a prospective randomized clinical trial.
Aim: Insulin treatment is considered to be the final option for patients with progressive type 2 diabetes. This study investigated, whether reconverting from insulin oral using pioglitazone possible without deterioration of blood glucose control. Methods: The PioSwitch was a prospective, open label, proof concept study. Thiazolidinedione‐naïve residual β‐cell function were switched an existing therapy and glimepiride 6 months. Efficacy assessed by laboratory parameters scores evaluation...
In recurrent head and neck cancer, therapeutic options are limited high-quality evidence is rare. The purpose of this report was to present our experience CT-guided interstitial high-dose rate (HDR) brachytherapy in 4 challenging cases inoperable cancer.A 53-year-old man with mucosal melanoma the paranasal sinuses, a 61-year-old myofibroblastic sarcoma nasal cavity, 51-year-old woman nasopharyngeal 44-year-old orbital leiomyosarcoma were treated reirradiation by HDR after previous...
Organs at risk (OARs), which are very close to a clinical target volume (CTV), can compromise effective tumor irradiation. The present study investigated the feasibility and safety of novel approach, in particular, extent dosimetric effect distancing CTV from adjacent OARs by means interventionally applied balloon catheters.Patients with peripheral hepatic malignancies, whom critical proximity an OAR assessment contrast-enhanced magnetic resonance imaging (MRI) scans preplanning process were...
18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is utilized for staging and treatment planning of head neck squamous cell carcinomas (HNSCC). Some older publications on the prognostic relevance showed inconclusive results, most probably due to small study sizes. This evaluates potentially predictive value FDG-PET in a large multi-center analysis.Original analysis individual patient data from 16 international centers (8 institutional datasets, 8 public repositories) with 1104...
Retinol binding protein 4 (RBP4) has recently been suggested as a good biomarker for insulin resistance and the metabolic syndrome. With this study, we wanted to investigate effect of pioglitazone (PIO) simvastatin (SIMVA) on RBP4 plasma concentrations in nondiabetic patients with syndrome increased risk cardiovascular complications. The prospective, parallel, randomized, double-blind clinical trial was performed 125 (78 females, 47 males, age (mean±STD): 58.6±7.8 years, BMI: 30.8±4.2...
Abstract This retrospective, multi-centered study aimed to improve high-quality radiation treatment (RT) planning workflows by training and testing a Convolutional Neural Network (CNN) perform auto segmentations of organs at risk (OAR) for prostate cancer (PCa) patients, specifically the bladder rectum. The objective this project was develop clinically applicable robust artificial intelligence (AI) system assist oncologists in OAR segmentation. CNN trained using manual contours CT-datasets...
Fragestellung: Patienten mit Typ 2 Diabetes mellitus leiden unter den Folgen einer klinisch signifikanten Insulinresistenz und ß-Zelldysfunktion, die in unterschiedlichen Schweregraden auftreten können. Patienten, bereits eine Insulintherapie erhalten könnten demnach auf orale Medikation Pioglitazon umgestellt werden, wenn im Vordergrund ihres Krankheitsbildes steht, z.B. anhand des Nüchtern C-Peptid/Proinsulin Quotienten ausreichende ß-Zellkapazität gezeigt werden kann. Ziel dieser...
Introduction:Radiation therapy plays a crucial role in the required multidisciplinary management of Head And Neck Cancer (HNC).The use highly sophisticated radiation techniques for HNC mandates precise target volumes and Organs at Risk (OARs) delineation, which can be challenging.Computerised contouring algorithms have shown potential by improving delineation precision, inter-observer consistency reducing workload.This study aims to evaluate commercially available...
Hintergrund: Die progrediente Verschlechterung der Glykämiekontrolle beim Typ 2 Diabetes macht bei vielen Patienten eine antidiabetische Kombinationsbehandlung erforderlich. Eine mögliche Therapieoption ist Einsatz Substanzen Metformin und Pioglitazon, die beide an zentralen pathophysiologischen Grundlagen Erkrankung ansetzen. Mittlerweile steht Fixkombination aus Pioglitazon 15mg 850mg competact® zur Verfügung. Wir haben Wirksamkeit Verträglichkeit dieser unter Praxisbedingungen untersucht.
Der Insulinsensitizer Pioglitazon ist für die Kombination mit Insulin bei Typ-2-Diabetikern zugelassen, allein unzureichend eingestellt sind und Metformin aufgrund von Kontraindikationen oder Unverträglichkeiten nicht geeignet ist. Seit Januar 2007 untersucht eine interventionelle Studie mehr als 4000 insulinbehandelten Wirksamkeit Verträglichkeit dieses Regimes unter Praxisbedingungen. Die erste Zwischenauswertung 2086 Studienteilnehmern zeigt klare Vorteile Add-on-Therapie Pioglitazon....
Einleitung: Patienten mit Typ-2-Diabetes (T2D) weisen ein erhöhtes Risiko für die Entwicklung makrovaskulärer Komplikationen wie z.B. Myokardinfarkte auf. Sowohl eine optimale Blutdruckeinstellung als auch Senkung der LDL-Cholesterin-Spiegel kann durch Therapie Statinen kardiovaskuläre Ereignisse bei T2D deutlich reduzieren. Für Pioglitazon (PIO), einem Thiazolidindion, welches Insulinresistenz verbessert, ist Reduktion kardiovaskulärer und Intima-Media-Dicke (IMT) Arteria carotis gezeigt...