A5039862095- Amyotrophic Lateral Sclerosis Research
- Ultrasound and Hyperthermia Applications
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Neurogenetic and Muscular Disorders Research
- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Nerve injury and regeneration
- Neurological diseases and metabolism
- Genetic Neurodegenerative Diseases
- Lung Cancer Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Head and Neck Surgical Oncology
- Ultrasound Imaging and Elastography
- Oral health in cancer treatment
- Cancer, Hypoxia, and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Electromagnetic Fields and Biological Effects
- Hereditary Neurological Disorders
- Esophageal Cancer Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Thermal Regulation in Medicine
- Anesthesia and Sedative Agents
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2020-2025
Freie Universität Berlin
2020-2025
University of Southern Denmark
2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020-2024
German Cancer Research Center
2020-2024
Heidelberg University
2020-2024
University of Zurich
2022
Medical University of Vienna
2022
University Medical Center Freiburg
2020
Hyperthermia has been shown to improve the effectiveness of chemotherapy and radiotherapy in treatment cancer. This paper summarises all recent clinical trials registered ClinicalTrials.gov registry.The records 175,538 at were downloaded on 29 September 2014 a database was established. We searched this for hyperthermia or equivalent words.A total 109 identified which part regimen. Of these, 49 (45%) had hyperthermic intraperitoneal after cytoreductive surgery (HIPEC) as primary intervention,...
Brain derived neurotrophic factor (BDNF) is a potent survival for motoneurons. This study investigated the safety and tolerability of recombinant methionyl human BDNF (r-metHuBDNF) infused intrathecally by means an implanted pump in patients with ALS.Twenty-five probable or definite ALS were treated either r-metHuBDNF (25, 60, 150, 400 1000 microg/day) placebo 12-week, randomized, double-blinded, sequential, dose-escalation study. Test treatment was interrupted washout period from days 11 to...
Abstract Predicting the rate of disease progression has become important as trials new medical treatments for amyotrophic lateral sclerosis (ALS) are planned. Bulbar onset, early impairment forced vital capacity, and older age have all been associated with shorter survival. We performed a retrospective study to compare survival factors in German ALS population. analyzed 155 patients at intervals 4 months over period 3 years. To evaluate progression, functional rating scale (ALS‐FRS),...
Synaptic inhibition is a central factor in the fine tuning of neuronal activity nervous system. Symptoms consistent with reduced such as stiffness, spasms and anxiety occur paraneoplastic stiff person syndrome autoantibodies against intracellular synaptic protein amphiphysin. Here we show that intrathecal application purified anti-amphiphysin immunoglobulin G antibodies induces syndrome-like symptoms rats, including stiffness muscle spasms. Using vivo recordings Hoffmann reflexes dorsal root...
Proximal spinal muscular atrophy (SMA) is a motoneuron disease for which there currently no effective treatment. In animal models of SMA, motoneurons exhibit reduced axon elongation and growth cone size. These defects correlate with β-actin messenger RNA protein levels in distal axons. We show that survival gene (Smn)–deficient severe clustering Cav2.2 channels axonal cones. also frequency local Ca2+ transients. contrast, global spontaneous excitability measured cell bodies proximal axons...
Abstract We explored the non-thermal effects of radiofrequency (RF) electromagnetic fields and established a theoretical framework to elucidate their electrophysiological mechanisms. In experiments, we used preclinical treatment device treat human colon cancer cell lines HT-29 SW480 with either water bath heating (WB-HT) or 13.56 MHz RF hyperthermia (RF-HT) at 42 °C for 60 min analyzed proliferation clonogenicity. elaborated an electrical model membranes ion channels estimated resulting...
The cause of sporadic amyotrophic lateral sclerosis (ALS) is largely unknown, but genetic factors are thought to play a significant role in determining susceptibility motor neuron degeneration. To identify variants altering risk ALS, we undertook two-stage genome-wide association study (GWAS): followed our initial GWAS 545 066 SNPs 553 individuals with ALS and 2338 controls by testing the 7600 most associated from first stage three independent cohorts consisting 2160 cases 3008 controls....
This pilot study aimed at exploring the effects of intrathecally administered brain derived neurotrophic factor (BDNF) on autonomic functions in patients with ALS. A battery sympathetic and parasympathetic tests was performed baseline after nine months treatment 10 ALS participating a double‐blind placebo‐controlled phase II/III BDNF. Results treated BDNF (25 or 150 µg/day) were compared to those receiving placebo. Sudomotor function blood pressure response handgrip significantly worsened...
By the use of PSMA positron emission tomography (PET) detection prostate cancer lesions with a high sensitivity and specificity combined favorable lesion to background contrast is feasible. Therefore, PSMA-PET increasingly used for planning radiotherapy treatment; however, any data on intermediate-term outcome missing so far. Patients high-risk or very risk cancer, referred salvage (SRT, n = 22) between 2013 2015, underwent prior therapy. Irradiation was planned PET boost macroscopic...
Many people with Multiple Sclerosis (MS) in Europe face limited treatment and care access. Research on the challenges faced by who do not access specialized MS is limited, leaving a gap understanding experiences of those attend care. Thus, we aimed to explore regular clinical follow-up clinics Denmark, special focus self-care. A qualitative study was conducted using individual interviews thematic analysis, following Braun Clarke's approach. Data were collected Denmark between September 2022...
Purpose: Preclinical studies and clinical observations suggest that amplitude modulation (AM) below 100 kHz may enhance the intratumoral power absorption of radiofrequency hyperthermia at 13.56 MHz; however, it remains unclear whether AM induces temperature-dependent effects.Methods: We established tumor models assuming typical architectures or cell suspensions to analyze effects additional dissipation. The preconditions for demodulation membranes in situ were outlined. bioheat transfer...
BackgroundCurrent segmentation approaches for radiation treatment planning in head and neck cancer patients (HNCP) typically consider the entire mandible as an organ at risk, while of maxilla remains uncommon. Accurate risk assessment osteoradionecrosis (ORN) or implant-based dental rehabilitation after therapy may require a nuanced analysis dose distribution specific mandibular maxillary segments. Manual is time-consuming inconsistent, there no definition jaw subsections.Materials...
Objective In the multimodal treatment of advanced head and neck malignancies, primary free flap reconstruction in a one stage procedure with tumor resection is frequently combined adjuvant radiotherapy. Radiotherapy known to exhibit side effects on transplanted flaps, including osteoradionecrosis (ORN) native bone. This study aims evaluate therapeutic outcomes potential predictors ORN within osseous flaps based large-scale, single-center database. Methods A retrospective analysis was...
Maximal voluntary isometric contraction (MVIC) is a standard tool for assessment of muscle strength in treatment trials amyotrophic lateral sclerosis (ALS). There need more practical bedside techniques especially severely disabled patients. Hand-held dynamometry (HH-Dyn) an inexpensive and easy-to-handle device. MVIC was measured five proximal groups bilaterally compared with HH-Dyn 43 ALS After training period we found good intrarater correlation (r = 0.99), low coefficient variation....
Autonomic dysregulation is part of the complex degenerative process in amyotrophic lateral sclerosis (ALS). To investigate this, sweating was examined at rest 39 patients with ALS comparison a control group. Sweat collected over 30 second period thenar and hypothenar eminences on sole foot, using commercial device based vapour pressure gradient. The measurements were repeated after three six months 10 for longitudinal analysis. In early ALS, had significantly higher skin water loss than...
Sporadic amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, most likely results from complex genetic and environmental interactions. Although number of association studies have been performed in an effort to find components sporadic ALS, them resulted inconsistent findings due small genes investigated relatively sample sizes, while the replication was rarely attempted. Defects retrograde axonal transport, vesicle trafficking xenobiotic metabolism implicated...
Abstract Detection of patients with esophageal squamous cell carcinoma (ESCC) who do not benefit from standard chemoradiation (CRT) is an important medical need. Radiomics using 18-fluorodeoxyglucose (FDG) positron emission tomography (PET) a promising approach. In this retrospective study 184 locally advanced ESCC. 152 one center were grouped into training cohort (n = 100) and internal validation 52). External was performed 32 treated at second center. Primary endpoint disease-free survival...