A5040752179- Head and Neck Cancer Studies
- Dental Implant Techniques and Outcomes
- Head and Neck Surgical Oncology
- Oral health in cancer treatment
- Reconstructive Surgery and Microvascular Techniques
- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Infective Endocarditis Diagnosis and Management
- Tumors and Oncological Cases
- Reconstructive Facial Surgery Techniques
- Lung Cancer Treatments and Mutations
- Facial Trauma and Fracture Management
- Vascular Malformations and Hemangiomas
- Histiocytic Disorders and Treatments
- Bone and Joint Diseases
- Cardiac Valve Diseases and Treatments
- HER2/EGFR in Cancer Research
- Bacterial Identification and Susceptibility Testing
- Ear Surgery and Otitis Media
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ocular Disorders and Treatments
- Dental materials and restorations
- Oral and Maxillofacial Pathology
- Nasal Surgery and Airway Studies
- Cancer Diagnosis and Treatment
Freie Universität Berlin
2019-2025
Charité - Universitätsmedizin Berlin
2019-2025
Humboldt-Universität zu Berlin
2019-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2022-2024
Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
2023
University of Tübingen
2023
Universitätsklinikum Würzburg
2015
Objective In the multimodal treatment of advanced head and neck malignancies, primary free flap reconstruction in a one stage procedure with tumor resection is frequently combined adjuvant radiotherapy. Radiotherapy known to exhibit side effects on transplanted flaps, including osteoradionecrosis (ORN) native bone. This study aims evaluate therapeutic outcomes potential predictors ORN within osseous flaps based large-scale, single-center database. Methods A retrospective analysis was...
ABSTRACT Reconstruction of critical‐size bone defects (CSDs) with complex defect morphologies remains clinically challenging. The desire to avoid autograft harvesting has prompted an increasing quest for adequate synthetic grafting materials. clinical success rates, which have been achieved bioactive β‐tricalcium phosphate granules (TCP‐G) demonstrate that these materials become excellent alternative graft choice. In order improve surgical handling properties, TCP‐G combined natural polymers...
Background/Aim: The current literature conjectures that oral squamous cell carcinoma (OSCC) in younger patients is an entirely separate entity with a different risk profile. We aimed to uncover the potential factors of OSCC and evaluated long-term outcome such patients. Patients Methods: This hospital-based case–control study included 40 controls under age 46 years. Survival was analyzed via Kaplan–Meier estimates, including follow-up up 24.3 Results: were prone smoking drinking heavily even...
The aim of this study was to investigate the influence real implant-bed-specific radiation doses on peri-implant tissue health in head and neck cancer (HNC) patients after radiotherapy.Specific area 81 implants, 15 irradiated HNC patients, were analyzed by matching data from radiotherapy planning system with those three-dimensional follow-up scans implantation. Peri-implant bone resorption measured radiographically 1 3 years, evaluated clinically. Individual parameters, such as age, gender,...
Langerhans cell histiocytosis (LCH) is a diagnostic and therapeutic challenge. We report on rare case of its primary oral manifestation that was treated successfully with the BRAF-specific agent, vemurafenib, after insufficient standard LCH treatment. This underlines importance proper diagnosis evaluation targeted therapy as valuable tool in Furthermore, close collaboration surgeons, oncologists, dentists mandatory to ensure adequate treatment, restore stomatognathic system debilitating...
Abstract Background Congenital heart defects (CHD) affect about 8 out of 1000 births worldwide. Most the patients reach adulthood and are exposed to an increased risk endocarditis. Since bacteria already enter bloodstream during everyday activities, oral hygiene is given special importance in prevention Methods In this study 81 boys (55.1%) 66 (44.9%) girls with CHD received a dental exam additionally assessment using DIAGNOdent® pen. This group consisting was matched healthy epidemiological...
Abstract Purpose Despite the differences in material properties and shapes among different types of prefabricated titanium (pTiA) individualized hybrid zirconia abutments (ihZiA), biological clinical relevance materials construction features remains vague. Yet, ihZiA are increasingly implemented into daily routine aiming to satisfy rising expectations. The objective was compare these two fixed dental prostheses (FDP). Methods This cross-sectional study examined 462 implants 102 patients...
Abstract Lately, the potential risk of disease transmission due to use bovine-derived bone substitutes has become obvious, demonstrating urgent need for a synthetic grafting material with comparable bioactive behaviour and properties. Therefore, effect hydroxyapatite (HA) (Osbone®) on regeneration was evaluated 2 weeks, 1 month, 3, 6, 12 18 months after implantation in critical-size defects ovine scapula compared that HA (Bio-Oss®) β-tricalcium phosphate (TCP) (Cerasorb® M). New formation...
BACKGROUND: Detecting local tumor recurrence from post-treatment changes in head and neck cancer (HNC) remains a challenge. Based on the hypothesis that post-therapeutically altered tissue is bradytroph, lower perfusion values are expected CT (PCT) while higher recurrent malignant tissue. OBJECTIVES: This prospective study investigates PCT for HNC detection with maximum slope algorithm. METHODS: A total of 80 patients who received post-therapy follow-up, which 63 had no 17 presented...
Radiotherapy of head and neck squamous cell carcinoma can lead to long-term complications like osteoradionecrosis, resulting in severe impairment the jawbone. Current standard procedures require a 6-month wait after irradiation before dental reconstruction begin. A comprehensive characterization irradiation-induced molecular functional changes bone cells could allow development novel strategies for an earlier successful patients treated by radiotherapy. The impact ionizing radiation on...
Abstract Objectives To investigate sonication as a new tool in microbiological probing of dental infections. Methods Comparison standard method: intraoperative swab, with sonication, and vortex the removed tooth, was performed on 20 carious destructed teeth. Illumina high throughput sequencing 16S-rRNA-gene used for assessing microbial composition. Antibiotic susceptibility has been assigned based known resistances each detected species. Probing procedures were compared using...
Purpose: To compare different assessment methods for peri-implant inflammation to evaluate potential risk factors and generate a comprehensive algorithm clinical staging, treatment, evaluation of success in periorbital implants. Materials Methods: In this hospital-based cross-sectional study, 111 implants 40 patients with orbital defects after exenteration were clinically analyzed. Skin reaction according Holgers (SRH), probing depth (PD) , sulcus fluid flow rate (SFFR), as well...
The aim of this study was to evaluate existing staging recommendations for peri-implantitis and its applicability auricular bone anchoring.
Abstract Purpose Compromised swallowing, speaking, and local complications are the major disadvantages of established approaches to posterior tongue oropharynx. The mandibular split involves an esthetically unpleasant bipartition lower lip is prone bony non-union or sequestration. conventional pull-through technique on other hand lacks secure reattachment lingually released soft tissues. Methods feasibility a new modified approach was tested three anatomical specimens. CAD/CAM cutting guides...
Abstract Purpose Compromised swallowing and speaking as well local complications are the major disadvantages of established approaches to posterior tongue oropharynx. The mandibular split involves an esthetically unpleasant bipartition lower lip is prone bony non-union or sequestration. traditional pull-through technique on other hand lacks safe reattachment lingually released soft tissues. Methods feasibility a new modified approach was tested three anatomical specimens. CAD/CAM cutting...