A5045653209- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Galectins and Cancer Biology
- Diverticular Disease and Complications
- Glycosylation and Glycoproteins Research
- Colorectal and Anal Carcinomas
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare cost, quality, practices
- Anorectal Disease Treatments and Outcomes
- Appendicitis Diagnosis and Management
- Colorectal Cancer Screening and Detection
- ATP Synthase and ATPases Research
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Hernia repair and management
- COVID-19 and healthcare impacts
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- Cholangiocarcinoma and Gallbladder Cancer Studies
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Stoma care and complications
- Macrophage Migration Inhibitory Factor
- Intraperitoneal and Appendiceal Malignancies
Universitätsklinikum Erlangen
2017-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2017-2024
University Hospital Carl Gustav Carus
2007-2023
Comprehensive Cancer Center Erlangen
2021
TU Dresden
2007-2019
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2007-2009
University Medical Center Freiburg
2000
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant desmoplastic stroma. Interactions between cancer and stromal cells play a critical role in tumour invasion, metastasis chemoresistance. Therefore, we hypothesized that gene expression profile of the components pancreatic carcinoma different from chronic pancreatitis reflects interaction with tumour. We investigated eleven tissues PDAC, nine cell lines origin using Affymetrix U133 GeneChip set. The tissue samples...
In the current era of precision oncology, it is widely acknowledged that CRC a heterogeneous disease entity. Tumor location (right- or left-sided colon cancer rectal cancer) crucial factor in determining progression as well prognosis and influences management. last decade, numerous works have reported microbiome an important element carcinogenesis, therapy response. Owing to nature microbiomes, findings these studies were inconsistent. The majority combined (CC) (RC) samples for analysis....
Kallikreins play an important role in tumour microenvironment and as cancer biomarkers different entities. Previous studies suggested upregulation of KLK10 KLK6 pancreatic ductal adenocarcinoma (PDAC). Therefore, we evaluated the clinicopathological these kallikreins their value PDAC. Differential expression was validated by DNA-microarrays immunohistochemistry normal malignant tissues. Sera concentrations both were using ELISA. In silico analysis possible protein interactions gene silencing...
Pancreatic cancer is the fourth leading cause for cancer-related death, and early diagnosis one key to improve survival rate of this disease. Molecular biomarkers are an important method diagnostic use in pancreatic cancer. We used data from three mRNA microarray datasets a microRNA dataset (GSE16515, GSE15471, GSE28735, GSE41372) identify potential genes. Differentially expressed genes (DEGs) microRNAs (DEMs) were identified. Functional, pathway enrichment, protein-protein interaction...
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest tumors worldwide. Understanding function gene expression alterations a prerequisite for developing new strategies in diagnostic and therapy. GPRC5A (RAI3), coding seven transmembrane G protein-coupled receptor known to be overexpressed pancreatic cancer might an interesting candidate therapeutic intervention. Expression levels RAI3 were compared using tissue microarray 435 resected patients with as well 209 samples from chronic...
To determine the impact of positive end-expiratory pressure during mechanical ventilation with and without spontaneous breathing activity on regional lung inflammation in experimental nonsevere acute respiratory distress syndrome.Laboratory investigation.University hospital research facility.Twenty-four pigs (28.1-58.2 kg).In anesthetized animals, intrapleural sensors were placed thoracoscopically ventral, dorsal, caudal regions left hemithorax. Lung injury was induced saline lavage followed...
Background Pancreatic ductal adenocarcinoma (PDAC) remains an important cause of cancer death. Changes in apoptosis signaling pancreatic result chemotherapy resistance and aggressive growth metastasizing. The aim this study was to characterize the pathway computationally by evaluation experimental data from high-throughput technologies public bases. Therefore, gene expression analysis microdissected tumor tissue implemented a model obtained computational protein interaction prediction....
Leakage of rectal anastomoses is one the most important and feared complications in colorectal surgery. Apart from patient-specific risk factors, technical aspects may influence occurrence anastomotic complications. This study investigated whether using single-stapling techniques (SST) instead double-stapling technique (DST) for minimal-invasive anastomosis associated with a lower rate complications.A retrospective review 272 patients who received minimally invasive stapled (3-16 cm anal...
The sialic acid-specific cytotoxic lectin viscumin and its recombinant equivalent rViscumin specifically bind to CD75s-gangliosides with terminal Neu5Acα6Galβ4GlcNAc sequence. We, therefore, comparatively analyzed the content of closely related iso-CD75s-gangliosides (terminated by Neu5Acα3Galβ4GlcNAc sequence) gene expression associated β-galactoside α-2,6-sialyltransferase 1 (ST6GAL1) α-2,3-sialyltransferase 6 (ST3GAL6), respectively, in 35 hepatocellular carcinoma (HCC) patients....
The RREB1::MRTFB (former RREB1::MKL2) fusion characterizes ectomesenchymal chondromyxoid tumors (EMCMT) of the tongue. Only five molecularly confirmed extra-glossal EMCMT cases have been reported recently; all occurring at head and neck or mediastinal sites. We herein describe new including first two extracranial/extrathoracic cases. occurred in three male female patients with an age ranging from 18 to 61 years (median, 28). Three were located (jaw, parapharyngeal space, nasopharyngeal wall)...
Abstract Purpose The optimal management of colorectal lung metastases (CRLM) is still controversial. aim this study was to compare surgical and non-surgical treatment for CRLM regarding the prognostic outcome. Methods This retrospective single-center cohort included 418 patients, who were treated from January 2000 December 2018 at a German University Hospital due their carcinoma had synchronous or metachronous metastases. Patients stratified according into two groups: resection versus no...
: This study aimed to determine the risk factors associated with postoperative major morbidity, anastomotic/suture leakage, re-surgery and mortality in patients undergoing emergency surgery for colonic perforation.
Common variable immunodeficiency (CVID) is characterized by defective B cell maturation and antibody formation resulting in low serum levels of most or all Ig isotypes. A specific subgroup patients ("type A") has normal numbers mature surface (s)IgM / sIgD- positive circulating cells. However, since these lymphocytes do not respond to vitro stimulation differentiation synthesis, they seem suffer from so far unknown intrinsic defects. Analyzing the expression pattern a large set...
Abstract Pancreatic adenocarcinoma confers one of the highest mortality rates in malignant human tumors with very poor prognosis. Because as yet no treatments are available that produce a substantial survival benefit for this fatal neoplasia, new therapeutic concepts urgently required to support cancer standard treatment. In search tumor-associated gangliosides background, we probed random collection cancerous and adjacent normal postoperative tissue samples from 38 patients expression...
The aim of the present study was to identify risk factors associated with postoperative morbidity and major morbidity, a prolonged length hospital stay need readmission in patients undergoing appendectomy due acute appendicitis.We performed retrospective analysis 1638 adult who underwent emergency for preoperatively suspected appendicitis from 2010 2020 at University Hospital Erlangen. Data including patient demographics, pre-, intra-, findings were collected compared between different...
Robot-assisted systems have been increasingly used in general surgery for several years. Accordingly, the number of installed Germany has also rapidly increased. While around 100 robot-assisted were German hospitals 2018, this figure had already risen to more than 200 by 2022. The aim article is present current state development and trends robotic Germany. For purpose, data from StuDoQ|Robotics register analyzed. Furthermore, a descriptive analysis concomitant diagnosis-related groups (DRG)...
Gender is increasingly recognized as an important factor in medicine, although it has long been neglected medical research many areas. We have studied the influence of gender advanced rectal cancer with a special focus on radiosensitivity. For this purpose, we cohort 495 men (84.1% ≥ T3, 63.6% N1, 17.6%, M1) and 215 women (84.2% 56.7% 22.8%, who all suffered from were treated radiochemotherapy. The energy deposited, DNA double-strand break (dsb) repair, occurrence chromosomal aberrations,...
Immunotherapy has become increasingly important in the treatment of colorectal cancer (CRC). Currently, CD73, also known as ecto-5'-nucleotidase (NT5E), gained considerable interest a potential therapeutic target. CD73 is one key enzymes catalyzing conversion extracellular ATP into adenosine, which turn exerts potent immune suppressive effects. However, role expression on various cell types within CRC tumor microenvironment remains unresolved. The been described recently, but B-cells...
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms cancer and peritoneal dissemination major cause for this poor prognosis. Exosomes have emerged as promising biomarkers gastrointestinal cancers can be found in all kinds bodily fluids, also fluid (PF). This a unique sample due to its closeness malignancies. The receptor tyrosine kinase-like orphan 1 (ROR1) has been identified potential biomarker human represents target an immunotherapy approach, which could...
Bacteria play an important role not only in pathogenesis of appendicitis but also the postoperative course patients. However, usefulness intraoperative swab during appendectomy is controversial. The primary aim this study was to investigate impact on outcome patients with uncomplicated and complicated appendicitis.A retrospective analysis conducted a consecutive series 1570 adult who underwent for acute at University Hospital Erlangen between 2010 2020. Data regarding were collected analyzed...
Abstract Introduction The purpose of this analysis was to investigate the most appropriate duration postoperative antibiotic treatment minimize incidence intraabdominal abscesses and wound infections in patients with complicated appendicitis. Materials methods In retrospective study, which included 396 adult who underwent appendectomy for appendicitis between January 2010 December 2020 at University Hospital Erlangen, were classified into two groups based on their intake: ≤ 3 days (group 1)...