A5030377027- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Tuberculosis Research and Epidemiology
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Autoimmune and Inflammatory Disorders
- Inflammatory Bowel Disease
- Mycobacterium research and diagnosis
- Chronic Myeloid Leukemia Treatments
- Glycosylation and Glycoproteins Research
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Immune responses and vaccinations
- Neuropeptides and Animal Physiology
- Pneumonia and Respiratory Infections
- Sarcoidosis and Beryllium Toxicity Research
- Microscopic Colitis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Microbial infections and disease research
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Inflammasome and immune disorders
- Pharmacological Receptor Mechanisms and Effects
Friedrich-Alexander-Universität Erlangen-Nürnberg
2017-2024
Universitätsklinikum Erlangen
2017-2024
Bordeaux Population Health
2009-2022
Inserm
2006-2022
Centre Hospitalier Universitaire de Bordeaux
2009-2022
Université de Toulouse
2015-2018
Université Toulouse III - Paul Sabatier
2010-2018
Centre National de la Recherche Scientifique
2015-2018
Institut de Pharmacologie et de Biologie Structurale
2013-2018
Centre de Physiopathologie de Toulouse-Purpan
2006-2010
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide health threat. In prospective multicentric study, we identify IL-3 as an independent prognostic marker for the outcome during SARS-CoV-2 infections. Specifically, low plasma levels associated with increased severity, viral load, and mortality Patients severe COVID-19 exhibit also reduced circulating plasmacytoid dendritic cells (pDCs) IFNα IFNλ when compared to non-severe patients. mouse model of pulmonary...
Rationale: In addition to their well-known function as antibody-producing cells, B lymphocytes can markedly influence the course of infectious or noninfectious diseases via antibody-independent mechanisms. tuberculosis (TB), cells accumulate in lungs, yet functional contribution host response remains poorly understood.Objectives: To document role TB an unbiased manner.Methods: We generated transcriptome isolated from Mycobacterium (Mtb)-infected mice and validated identified key pathways...
DC-SIGN (CD209/CLEC4L) is a C-type lectin receptor (CLR) that serves as reliable cell-surface marker of interleukin 4 (IL-4)-activated human macrophages (M(IL-4)), which historically represent the most studied subset within M2 spectrum macrophage activation. Although plays important roles in Mycobacterium tuberculosis (Mtb) interactions with dendritic cells, its contribution to Mtb-macrophage interaction remains poorly understood. Since high levels IL-4 are correlated Tuberculosis (TB)...
Advanced colorectal carcinoma (CRC) is characterized by a high frequency of primary immune evasion and refractoriness to immunotherapy. Given the importance interferon (IFN)-γ in CRC immunosurveillance, we investigated whether how acquired IFN-γ resistance tumor cells would promote growth, sensitivity could be restored.Spontaneous colitis-associated development was induced mice with specific pathway inhibition intestinal epithelial cells. The influence gene status expression on survival...
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, initially discovered as part of the NPM-ALK fusion protein, resulting from t(2;5) translocation that frequently associated with anaplastic large-cell lymphomas. The native ALK protein normally expressed in developing and, at weaker level, adult nervous system. We recently demonstrated oncogenic, constitutively kinase-activated was antiapoptotic when Jurkat lymphoblastic cells treated cytotoxic drugs. In contrast, we now show...
T lymphocytes and eosinophils are important components of the inflammatory cell infiltrate in bronchial mucosa asthma. Because activated migrate through thoracic duct general circulation to remote glandular mucosal sites, we initiated this study evaluate pathological abnormalities immunoreactivity for interleukin (IL) 3, IL-5, granulocyte/macrophage colony-stimulating factor (GM-CSF) intestinal 15 asthmatic patients, 8 nonasthmatic patients with chronic obstructive pulmonary disease, 6...
Inflammatory bowel diseases (IBDs) are a global health issue with an increasing incidence. Although the pathogenesis of IBDs has been investigated intensively, etiology remains enigmatic. Here, we report that interleukin-3 (Il-3)-deficient mice more susceptible and exhibit increased intestinal inflammation during early stage experimental colitis. IL-3 is locally expressed in colon by cells harboring mesenchymal stem cell phenotype protects promoting recruitment splenic neutrophils high...
The granuloma is an elaborated aggregate of immune cells found in non-infectious as well infectious diseases. It a hallmark tuberculosis (TB). Predominantly thought host-driven strategy to constrain the bacilli and prevent dissemination, recent discoveries indicate can also be modulated into efficient tool promote microbial pathogenesis. aim future studies will certainly focus on better characterization mechanisms driving modulation functions. Here, we provide unique perspectives from both...
The performances of five commercial TaqMan real-time PCR assays for the detection Mycoplasma pneumoniae in respiratory tract specimens were evaluated comparison with an in-house PCR. All kits allowed prompt and specific results, validated by use internal control. Nanogen kit showed best clinical sensitivity.
Background: Excess bodyweight is known to influence the risk of colorectal cancer; however, little evidence exists for body mass index (BMI) on long-term outcome patients with rectal cancer. Methods: We assessed impact BMI local recurrence, distant metastasis and overall—survival in 612 between 2003 2010 after cancer diagnosis treatment at University Hospital Erlangen. A Cox-regression model was used estimate hazard ratio multivariate mortality distant-metastasis. Median follow up-time 58...
Electrochemiluminescence (ECL) has an inherently low background and enables precise chemical reactions through electrical control. Here, we report advanced ECL system, termed ECLipse (ECL in paired signal electrode). We physically separated generation from target detection: These two processes were carried out isolated chambers coupled electrode. The strategy allowed us to minimize cross-chemical reactions, design electrodes for high signals, integrate multiple sensors a chip. As proof of...
Rationale Sepsis, a global health burden, is often complicated by viral infections leading to increased long-term morbidity and mortality. Interleukin-3 (IL-3) has been identified as an important mediator amplifying acute inflammation in sepsis; however, its function the host response during sepsis remains elusive. Objectives To investigate role of IL-3 pneumonia sepsis. Methods We included septic patients from two different cohorts used vitro vivo assays. The obtained data were...
Interleukin (IL)-3 has long been known for its hematopoietic properties. However, recent evidence expanded our understanding of IL-3 function by identifying as a critical orchestrator inflammation in wide array diseases. Depending on the type disease, course inflammation, cell or tissue involved, promotes either pathologic resolution. Here, we describe cell-specific functions and summarize role We discuss current treatments targeting receptor, highlight potential limitations clinics.
Understanding the molecular components of immune recognition tuberculosis (TB) bacillus, Mycobacterium tuberculosis, can help designing novel strategies to combat TB. Here, we identify collectin CL-LK as a soluble C-type lectin able bind M. and characterize mycobacterial mannose-capped lipoarabinomannan primary ligand for CL-LK. Mice deficient in CL-K1, one subunits, do not display altered susceptibility tuberculosis. However, found that amount serum patients with active TB is reduced,...
Pancreatic ductal adenocarcinoma (PDAC) ranks among the most fatal cancer diseases, widely accepted to have dismal prognoses. Although immunotherapy has broadly revolutionized treatment, its value in PDAC appears be relatively low. Exhibiting protumoral effects, monocytes recently been proposed as potential targets of such immunotherapeutic regimens. However, date, body evidence on monocytes’ role is scarce. Therefore, we analyzed peripheral blood 58 patients prior surgery and compared them...
Crohn's disease is a granulomatous systemic disorder of unknown aetiology. Obvious pulmonary involvement exceptional. We report the case 33 year old woman treated with mesalazine for and presenting dyspnoea. Pulmonary function tests showed restrictive ventilatory pattern hypoxaemia on exertion. Chest radiography disclosed an interstitial ground glass high resolution computer tomography. Clinical radiological abnormalities progressed after withdrawal mesalazine. Corticosteroids led to partial...
Patients with pancreatic ductal adenocarcinoma (PDAC) normally have a poor long-term prognosis. However, some rare cases of survivors been reported. The tumor microenvironment, consisting cellular and stromal components, possibly plays an important role might influence In this context, the tumor-infiltrating B-cells its impact on survival in patients PDAC remains controversial. We therefore aimed to assess prognostic value CD20-positive B-cell aggregates as well CD138, IgM, Pax5, Ki67 using...
Abstract Purpose Colorectal cancer is a well-recognized complication of inflammatory bowel diseases (IBD), such as ulcerative colitis (UC) and Crohn’s (CC). In this study, we assess the clinico-pathological features outcomes patients with colorectal from UC in comparison CC. Methods Data all colitis-associated (CAC) who underwent surgery at Erlangen or Würzburg University Clinic between 1995 2015 were selected. Clinical, histopathological, survival data analyzed retrospectively. Results Of...
Immunotherapy has become increasingly important in the treatment of colorectal cancer (CRC). Currently, CD73, also known as ecto-5'-nucleotidase (NT5E), gained considerable interest a potential therapeutic target. CD73 is one key enzymes catalyzing conversion extracellular ATP into adenosine, which turn exerts potent immune suppressive effects. However, role expression on various cell types within CRC tumor microenvironment remains unresolved. The been described recently, but B-cells...
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms cancer and peritoneal dissemination major cause for this poor prognosis. Exosomes have emerged as promising biomarkers gastrointestinal cancers can be found in all kinds bodily fluids, also fluid (PF). This a unique sample due to its closeness malignancies. The receptor tyrosine kinase-like orphan 1 (ROR1) has been identified potential biomarker human represents target an immunotherapy approach, which could...