A5005194482- Animal Behavior and Reproduction
- Avian ecology and behavior
- Plant and animal studies
- Bird parasitology and diseases
- Wildlife Ecology and Conservation
- Epigenetics and DNA Methylation
- Genetic diversity and population structure
- Amphibian and Reptile Biology
- Species Distribution and Climate Change
- Diversity and Career in Medicine
- Cancer, Hypoxia, and Metabolism
- Gender Diversity and Inequality
- Genetics, Aging, and Longevity in Model Organisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Physiological and biochemical adaptations
- Insect and Arachnid Ecology and Behavior
- Animal Behavior and Welfare Studies
- Animal Vocal Communication and Behavior
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Animal Nutrition and Physiology
- Glycosylation and Glycoproteins Research
- Systemic Sclerosis and Related Diseases
- Cytokine Signaling Pathways and Interactions
- Cancer Cells and Metastasis
University of South Dakota
2017-2024
University of Exeter
2014-2023
Universitätsklinikum Erlangen
2014-2022
Friedrich-Alexander-Universität Erlangen-Nürnberg
2013-2022
Helmholtz Zentrum München
2018
University of South Florida
2009-2016
Archbold Biological Station
2016
University of Otago
2016
Armstrong Atlantic State University
2013
Klinikum Ingolstadt
2012
The spread of invasive species presents a genetic paradox: how do individuals overcome the barriers associated with introductions (e.g., bottlenecks and founder effects) to become adapted new environment? In addition diversity, epigenetic variation also contributes phenotypic could influence an introduced in novel environments. This may occur through two different (non-mutually exclusive) mechanisms. Individuals benefit from existing (and heritable) diversity or de novo marks increase...
Summary 1. A central tenet of life‐history theory is that investment in reproduction compromises survival. However, the underlying physiological mechanisms link to survival are poorly understood, particularly wild populations. 2. Previous experiments brown anole lizard ( Anolis sagrei ) show elimination via surgical ovariectomy results a dramatic increase females. We hypothesized this trade‐off reflects differences energy allocation between and processes influence 3. To test hypothesis, we...
Global anthropogenic changes are occurring at an unprecedented rate; one change, human-facilitated introduction of species outside their native range, has had significant ecological and economic impacts. Surprisingly, what traits facilitate range expansions post-introduction is relatively unknown. This information could help predict future introduced as well shifting ranges climate conditions change. Here, we asked whether specific behavioural physiological were important in the ongoing...
Summary Ecologists are becoming increasingly interested in characterizing immunological variation among and within species. However, many of the techniques available to immunologists not viable for use non‐model species, which limits resolution progress ecoimmunological research. Recently, an assay was developed quantify capacity blood or plasma kill microorganisms vitro . Such assays ideal ecologists because they provide holistic, integrated measures immune function with minimal sample size...
Emerging concepts in developmental biology, such as facilitated variation and dynamical patterning modules, address a major shortcoming of the Modern Synthesis Biology: how genotypic is transduced into functional yet diverse phenotypic variation. Still, we lack theory to explain at cellular tissue level coordinated whole-organism level, especially priority functions change over an individual's lifetime are influenced by environmental Here, propose that interactions among limited subset...
The ability to adjust behavioral responses environmental cues probably contributes an individual's persist in unfamiliar habitats. One behavior, how individual responds novelty, influences the acquisition of resources (e.g., novel foods) and identification stressors, but it may also increase exposure risks. Here, using house sparrows ( Passer domesticus ) recently introduced Kenya, we tested range expansion influenced individuals' foods objects. We predicted that edge birds would be less...
Different tumor microenvironments (TMEs) induce stromal cell plasticity that affects tumorigenesis. The impact of TME-dependent heterogeneity endothelial cells (TECs) on tumorigenesis is unclear. Here, we isolated pure TECs from human colorectal carcinomas (CRCs) exhibited TMEs with either improved (Th1-TME CRCs) or worse clinical prognosis (control-TME CRCs). Transcriptome analyses identified markedly different gene clusters reflected the tumorigenic and angiogenic activities respective...
Advanced colorectal carcinoma (CRC) is characterized by a high frequency of primary immune evasion and refractoriness to immunotherapy. Given the importance interferon (IFN)-γ in CRC immunosurveillance, we investigated whether how acquired IFN-γ resistance tumor cells would promote growth, sensitivity could be restored.Spontaneous colitis-associated development was induced mice with specific pathway inhibition intestinal epithelial cells. The influence gene status expression on survival...
Despite a move toward gender parity in the United States (U.S.) workforce, large gap persists fields of science, technology, engineering, and mathematics (STEM); this is particularly true for academic (i.e., instructor tenure track) STEM positions. This increases as women advance through traditional steps academia, with highest degree disparity tenured As policies, politics, culture, which all contribute to equity across world, vary regions States, we expect that might also geographic...
Gamma interferon (IFN-γ) regulates immune defenses against viruses, intracellular pathogens, and tumors by modulating cell proliferation, migration, invasion, vesicle trafficking processes. The large GTPase guanylate binding protein 1 (GBP-1) is among the cellular proteins that most abundantly induced IFN-γ mediates its biologic effects. As yet, molecular mechanisms of action GBP-1 remain unknown. Applying an interaction proteomics approach, we identified actin as a strong specific partner...
Summary 1. Glucocorticoid hormones are an integral part of the vertebrate stress response, and theoretical models argue for a link between glucocorticoid levels individual fitness. The cort‐fitness hypothesis posits that elevated baseline glucocorticoids reflective in poor condition with reduced likelihood survival. Surprisingly, this remains virtually untested juvenile life‐history stage, period is often characterized by high mortality rates. 2. To address issue, we explored whether just...
Abstract Following an introduction, non-native species are exposed to environments that differ from those found in their native range; further, as these expand beyond the site of they must constantly adapt novel environments. Although introduced present across most ecosystems, few have successfully established themselves on a truly global scale. One such species, house sparrow Passer domesticus, is now one world’s broadly distributed vertebrate and has been great part its current range. To...
As ranges expand, individuals encounter different environments at the periphery than centre of range. Previously, we have shown that glucocorticoids (GCs) vary with range expansion: edge release more GCs in response to restraint. Here, measured hippocampal mRNA expression GC receptors (mineralocorticoid, MR and glucocorticoid, GR) eight house sparrow ( Passer domesticus ) populations varying age. We found closest had lowest relative GR; all likelihood, this relationship was driven by a...
To describe the relationship between sleep-symptom severity and number of days to return play following concussion in student-athletes. Case series. A D1 NCAA university athletic department (institutional care). The study enrolled 84 varsity athletes who suffered a sport-related at from 2015 2021. Prior concussion(s), total symptom burden, sleep symptomatology (sleeping more, sleeping less, trouble falling asleep, drowsiness, fatigue) scores as reported using Post-Concussion Symptom Scale...
Some species thrive in captivity but others exhibit extensive psychological and physiological deficits, which can be a challenge to animal husbandry conservation as well wild immunology. Here, we investigated whether duration impacted the regulation of key innate immune response, inflammation, common bird species, house sparrow (Passer domesticus). Inflammation is one most commonly induced fast-acting responses animals mount upon exposure parasite. However, attenuation resolution...
Interactions between hosts and parasites influence the success of host introductions range expansions post-introduction. However, physiological mechanisms mediating these outcomes are little known. In some vertebrates, variation in regulation inflammation has been implicated, perhaps because imparts excessive costs, including high resource demands collateral damage upon encounter with novel parasites. Here, we tested hypothesis that contributed to spread house sparrows (Passer domesticus)...
Adult and childhood obesity rates are increasing. Childhood obesity, in particular, is a complicated, multifactorial condition that not always explained by overeating. To address rising of researchers have begun to how the composition gastrointestinal microbiome influences metabolism, energy absorption, weight regulation. Colonization gut begins early life highly influenced method birth (vaginal versus Caesarean), feeding (formula breastfeeding), exposure antibiotics. Not surprisingly, an...
TWIST1 is a member of the class B basic helix-loop-helix transcription factors that regulates cell lineage determination and differentiation has been implicated in epithelial-to-mesenchymal transition. Here, we aimed to investigate role for activation resident fibroblasts systemic sclerosis (SSc).The expression Twist1 was modulated by forced overexpression or siRNA-mediated knockdown. Interaction Twist1, E12 inhibitor Of (Id) analysed co-immunoprecipitation. The vivo evaluated using...
Reports of anticancer and immunosuppressive properties have spurred recent interest in the bacterially produced prodiginines. We use electrospray tandem mass spectrometry (ES-MS/MS) to investigate prodigiosin, undecylprodiginine, streptorubin B (butyl-meta-cycloheptylprodiginine) explore their fragmentation pathways explain unusual methyl radical loss consecutive fragment ions that dominate low-energy collision-induced dissociation (CID) spectra. The competition between formation...
Introduced species offer an opportunity to study the ecological process of range expansions. Recently, 3 mechanisms have been identified that may resolve genetic paradox (the seemingly unlikely success introduced given expected reduction in diversity through bottlenecks or founder effects): multiple introductions, high propagule pressure, and epigenetics. These are probably also important expansions (either natural anthropogenic), yet this possibility remains untested vertebrates. We used...
Two adaptationist hypotheses have been proposed to explain why stress, particularly elevation of stress hormones (i.e. glucocorticoids), tends suppress immune functions. One is that suppression represents efforts minimize autoimmune responses self-antigens released as organisms cope with stressors the autoimmune-avoidance hypothesis). The other occurs promote a shunting resources life processes more conducive survival stressor re-allocation Here in wild-caught house sparrows (Passer...