A5029933928- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Nosocomial Infections in ICU
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Advanced Glycation End Products research
- Immune cells in cancer
- Acute Kidney Injury Research
- Antifungal resistance and susceptibility
- Inflammation biomarkers and pathways
- Hemodynamic Monitoring and Therapy
- Vagus Nerve Stimulation Research
- Cardiac, Anesthesia and Surgical Outcomes
- Epigenetics and DNA Methylation
- Cardiac and Coronary Surgery Techniques
- Neonatal Respiratory Health Research
- Bacterial Identification and Susceptibility Testing
- Liver Disease and Transplantation
- Immune responses and vaccinations
- Cancer, Stress, Anesthesia, and Immune Response
- Optical Imaging and Spectroscopy Techniques
- Heart Rate Variability and Autonomic Control
- Gut microbiota and health
- Diabetic Foot Ulcer Assessment and Management
- Antibiotics Pharmacokinetics and Efficacy
Heidelberg University
2016-2025
University Hospital Heidelberg
2016-2025
Medizinische Hochschule Hannover
2020
Universitätsklinikum Gießen und Marburg
2010-2018
Pfizer (United States)
2018
Justus-Liebig-Universität Gießen
2010-2014
Giessen School of Theology
2014
Sepsis is a frequently fatal condition characterized by an uncontrolled and harmful host reaction to microbial infection. Despite the prevalence severity of sepsis, we lack fundamental grasp its pathophysiology. Here report that cytokine interleukin-3 (IL-3) potentiates inflammation in sepsis. Using mouse model abdominal showed innate response activator B cells produce IL-3, which induces myelopoiesis Ly-6C(high) monocytes neutrophils fuels storm. IL-3 deficiency protects mice against In...
Septic coagulopathy represents a very dynamic disease entity, tilting from initial hypercoagulability towards subsequent hypocoagulable state, entitled overt disseminated intravascular coagulation. Acute fibrinolysis shutdown has recently been described to be crucial component of in critically ill patients, although the underlying pathomechanisms, specific temporal kinetics and its outcome relevance patients with sepsis remain determined.In total, 90 (30 septic shock, 30 surgical controls...
Long-lasting impairment of the immune system is believed to be underlying reason for delayed deaths after surviving sepsis. We tested hypothesis persisting changes in survivors sepsis first time.In our prospective, cross-sectional pilot study, eight former patients who survived catecholamine-dependent and control individuals matched age, sex, diabetes renal insufficiency were enrolled. Each participant completed a questionnaire concerning morbidities, medications infection history....
Acute kidney injury (AKI) secondary to sepsis results in poor outcomes and conventional function indicators lack diagnostic value. Soluble urokinase plasminogen activator receptor (suPAR) is an innate immune-derived molecule implicated inflammatory organ damage. We characterized the ability of longitudinal serum suPAR levels discriminate severity course sepsis-induced AKI (SI-AKI) 200 critically ill patients meeting Sepsis-3 criteria. The pathophysiologic relevance varying SI-AKI was...
Abstract Background Preoperative risk prediction in patients at elevated cardiovascular shows limited accuracy. Platelet to lymphocyte ratio (PLR) and neutrophil (NLR) indicate systemic inflammation. Both have been investigated for outcome the field of oncology medicine, as well adverse events non-surgical increased risk. Methods For this post-hoc analysis, we included all 38 coronary heart disease from Leukocytes Cardiovascular Perioperative Events cohort-1 study scheduled elective...
Immunotherapies have recently gained traction as highly effective therapies in a subset of late-stage cancers. Unfortunately, only minority patients experience the remarkable benefits immunotherapies, whilst others fail to respond or even come harm through immune-related adverse events. For immunotherapies within PD-1/PD-L1 inhibitor class, patient stratification is currently performed using tumor (tissue-based) PD-L1 expression. However, an accurate predictor response ~30% cases. There...
The highly conserved Notch signaling pathway essentially participates in immunity through regulation of developmental processes and immune cell activity. In the adaptive system, impact cascade T B differentiation is well studied. contrast, function myeloid lineage during infection poorly understood. Here we show that TLR signaling, triggered LPS stimulation or vitro with various Gram negative positive bacteria, stimulates receptor ligand Delta-like 1 (DLL1) expression human blood-derived...
Innate immune memory describes the functional reprogramming of innate cells after pathogen contact, leading to either an improved (trained immunity) or a diminished (immune tolerance) response secondary stimulus. Immune tolerance “sepsis-induced immunosuppression” is typical hallmark patients sepsis survival, characterized by hypo-responsiveness host’s system. This condition renders host vulnerable for persisting infection occurrence secondary, often opportunistic infections, along with...
Objectives: The impact of TREM-1-mediated inflammation was investigated in different inflammatory settings.Methods: Secondary analyses an observational clinical pilot study, including 60 patients with septic shock, 30 postoperative controls and healthy volunteers.Results: Plasma levels sTREM-1 were found to identify shock more effectively than procalcitonin C-reactive protein. Moreover, identified be early predictor for survival shock.Conclusion: Due its diagnostic as well prognostic value...
Postoperative complications are of great relevance in daily clinical practice, and the gut microbiome might play an important role by preventing pathogens from crossing intestinal barrier. The two aims this prospective pilot study were: (1) to examine changes following pancreatic surgery, (2) correlate these with postoperative course patient. In total, 116 stool samples 32 patients undergoing surgery were analysed 16S-rRNA gene next-generation sequencing. One sample per patient was collected...
Background Sepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by host's systemic inflammatory response to infection are not yet fully understood. During sepsis, immune system confronted with variety factors, which integrated within individual cells result their basal state responsiveness. Epigenetic mechanisms like histone modifications known participate control reactions, but so far situation during sepsis...
Objectives: Sepsis-induced acute kidney injury is the dominant etiology in critically ill patients and often associated with a need for renal replacement therapy. The indication timing of therapy are controversially discussed. We hypothesized that product G 1 -cell cycle arrest biomarkers tissue inhibitor metalloproteinase-2 insulin-like growth factor-binding protein 7 ([TIMP-2] × [IGFBP7]), soluble urokinase-type plasminogen activator receptor diagnostic value prediction septic courses...
In response to the unmet need for timely accurate diagnosis and prognosis of acute infections sepsis, host-immune-response-based tests are being developed help clinicians make more informed decisions including prescribing antimicrobials, ordering additional diagnostics, assigning level care. One such test (InSep™, Inflammatix, Inc.) uses a 29-mRNA panel determine likelihood bacterial infection, separate viral risk physiologic decompensation (severity illness). The test, implemented in rapid...
Microcirculatory alterations are key mechanisms in sepsis pathophysiology leading to tissue hypoxia, edema formation, and organ dysfunction. Hyperspectral imaging (HSI) is an emerging technology that uses tissue-light interactions evaluate biochemical characteristics including oxygenation, hemoglobin content water content. Currently, clinical data for HSI technologies critical ill patients still limited. TIVITA® Tissue System was used measure oxygenation (StO2), Hemoglobin Index (THI), Near...
Abstract Background Sepsis-associated acute kidney injury (SA-AKI) is a prevalent and severe complication in critically ill patients. However, diagnostic therapeutic advancements have been hindered by the biological heterogeneity underlying disease. Both transcriptomic endotyping biomarker profiling proposed individually to identify molecular subtypes of sepsis may enhance risk stratification. This study aimed evaluate utility combining with protein-based biomarkers for improving...
Abstract Introduction The role of reactive carbonyl species, such as methylglyoxal (MG), has been overlooked within the context sepsis syndrome. aims this study were to assess impact MG formation in different inflammatory settings and evaluate its use for early diagnosis well prognosis Methods In total, 120 patients three groups enrolled observational clinical pilot study. included with septic shock (n = 60), postoperative controls 30), healthy volunteers 30). Plasma samples from collected...