A5032251994- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Prostate Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Meningioma and schwannoma management
- Salivary Gland Tumors Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Ear and Head Tumors
- Radiation Therapy and Dosimetry
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Trigeminal Neuralgia and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Research Studies
- Artificial Intelligence in Healthcare and Education
- Colorectal Cancer Surgical Treatments
- Advances in Oncology and Radiotherapy
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
Comprehensive Cancer Center Erlangen
2020-2025
Universitätsklinikum Erlangen
2016-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Radiation Oncology Associates
2019
Universitätsklinik für Strahlentherapie
2015
The potential of large language models in medicine for education and decision-making purposes has been demonstrated as they have achieved decent scores on medical exams such the United States Medical Licensing Exam (USMLE) MedQA exam. This work aims to evaluate performance ChatGPT-4 specialized field radiation oncology.
Abstract Background Promptable foundation auto-segmentation models like Segment Anything (SA, Meta AI, New York, USA) represent a novel class of universal deep learning that could be employed for interactive tumor auto-contouring in RT treatment planning. Methods was evaluated an point-to-mask task glioma brain 16,744 transverse slices from 369 MRI datasets (BraTS 2020 dataset). Up to nine point prompts were automatically placed per slice. Tumor boundaries auto-segmented on contrast-enhanced...
Background: While the role of stereotactic radiotherapy for brain metastases is increasing, evidence on comparative efficacy and safety fractionated (FSRT) single-session radiosurgery (SRS) scarce. Methods: Longitudinal volumetric analysis was performed in a consecutive cohort 120 patients 190 (>0.065 cm³ volume / >~5 mm diameter) treated exclusively with FSRT (n=98) SRS (n=92), respectively. A total 972 tumor segmentations used, averaging 5.1 time points per metastasis. Progression defined...
Deep learning-based head and neck lymph node level (HN_LNL) autodelineation is of high relevance to radiotherapy research clinical treatment planning but still underinvestigated in academic literature. In particular, there no publicly available open-source solution for large-scale autosegmentation HN_LNL the setting.An expert-delineated cohort 35 CTs was used training an nnU-net 3D-fullres/2D-ensemble model 20 different HN_LNL. A second acquired at same institution later time served as test...
ABSTRACT Background The purpose of this study was to evaluate risk factors that influence overall survival (OS)/disease‐free (DFS)/locoregional recurrence‐free (LRFS), and distant metastases‐free (DMFS) in patients with high‐risk primary salivary gland carcinoma who underwent surgery postoperative (chemo)radiotherapy curative intention. Methods We reviewed data 63 a retrospective single‐center audit. Results At median follow‐up 31 months (range, 5–145 months), cumulative OS DFS were 91.7%,...
Osteoarthritis (OA) is the leading degenerative joint disease in western world and leads, if left untreated, to a progressive deterioration of functionality, ultimately reducing quality life. Recent data has shown, that especially OA ankle foot are among most frequently affected regions. Current research points towards complex involvement various cell tissue types, often accompanied by inflammation. Low-dose radiotherapy (LDRT) widely used for treatment inflammatory diseases. While reported...
Abstract Distortions in brain MRI caused by gradient nonlinearities may reach several millimeters, thus distortion correction is strongly recommended for radiotherapy treatment planning. However, the significance of on actual clinical outcomes has not been described yet. Therefore, we investigated impact planning subsequent local control a historic series 419 metastases 189 patients treated with stereotactic between 01/2003 and 04/2015. Local was evaluated using volumetric extension RANO-BM...
Abstract Alterations in Homologous Recombination Repair (HRR) Pathway genes have been found to be associated with HR‐Deficiency (HRD), which is an approved biomarker for PARP Inhibitor (PARPi) treatment. The aim of a Molecular Tumor Board (MTB) identify molecular alterations cancer patients advanced tumors that may suggest off‐label treatment options. So far, few studies analyzed the presence HRR gene mutations and their association HRD outside clinical studies. Currently, no data on testing...
Abstract Background There is a large lack of evidence for optimal treatment in oligometastatic head and neck cancer it especially unclear which patients benefit from radical local all tumour sites. Methods 40 with newly diagnosed received sites 14.02.2008 to 24.08.2018. Primary endpoint was overall survival. Time occurrence new distant metastases control were evaluated as secondary endpoints well prognostic factors univariate und multivariate Cox’s regression analysis. To investigate the...
There is insufficient understanding of the natural course volumetric regression in brain metastases after stereotactic radiotherapy (SRT) and optimal criteria for assessment response progression clinical trials are currently unknown.Volumetric analysis via whole-tumor segmentation contrast-enhanced 1 mm³-isotropic T1-Mprage sequences before SRT during follow-up. A total 3,145 MRI studies 419 from 189 patients were segmented. Progression was defined using a extension RANO-BM criteria. subset...
Background The incidence of local failure and residual tumor after definitive chemoradiation therapy (dCRT) for locally advanced non-small-cell lung cancer remains high, irrespective applied radiation dose (>59 Gy). So-called salvage surgery has been suggested as a feasible treatment option non-small cell (NSCLC). Experience with (SLS) is limited, long-term survival rarely reported. Patient selection criteria surgical are not defined. aim this study was to assess postoperative...
This study aimed to differentiate primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM) via multimodal MRI featuring radiomic analysis. data sets of patients with histological proven PCNSL GBM were analyzed retrospectively. Diffusion-weighted imaging (DWI) dynamic susceptibility contrast (DSC) perfusion evaluated enhancing intracerebral lesions. Selective (contrast enhanced tumor area the highest mean cerebral blood volume (CBV) value) unselective (contouring whole lesion)...
Incidence of local relapse after definitive chemoradiation (>59 Gy) for locally advanced non-small-cell lung cancer (NSCLC) is high, irrespective high dose radiation applied. Experience with salvage resections in patients relapsed NSCLC limited. We present our series curative-intent tumor.Nine consecutive tumor recurrence or persistence following were reviewed. Kaplan-Meier analysis was used to assess patient survival.All received (median 66.2 concurrent chemotherapy. Tumor stage prior IIIA...
Pathologic complete response (pCR) is dominant prognostic factor determining favorable outcome in locally advanced non-small cell lung cancer (NSCLC) after induction therapy (IT). There no non-operative diagnostics that adequately estimates the pCR. Aim of this retrospective study was to assess correlation between clinical and pathological factors patients with pCR.Twenty-five pCR curative resection following IT were assessed using univariate multivariate Cox regression descriptive analysis....