A5022079871- Lung Cancer Treatments and Mutations
- Parasites and Host Interactions
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Immune responses and vaccinations
- Colorectal Cancer Treatments and Studies
- Tuberculosis Research and Epidemiology
- IL-33, ST2, and ILC Pathways
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Statistical Methods in Clinical Trials
- Head and Neck Surgical Oncology
- Renal cell carcinoma treatment
- PI3K/AKT/mTOR signaling in cancer
- Eosinophilic Esophagitis
- Phagocytosis and Immune Regulation
- Multiple and Secondary Primary Cancers
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Neonatal Respiratory Health Research
- Oral and Maxillofacial Pathology
- Colorectal Cancer Surgical Treatments
- Renal and related cancers
- Immune cells in cancer
- Cardiac tumors and thrombi
Comprehensive Cancer Center Erlangen
2021-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2018-2024
Universitätsklinikum Erlangen
2018-2024
Zentrum für Psychiatrie Emmendingen
2024
RetnlaCre fate mapping mice reveal differentiation, tissue localization, and in vivo functions of RELMα + macrophages.
In non-small cell lung cancer (NSCLC), approximately 1-3% of cases harbor an increased gene copy number (GCN) the MET gene. This alteration can be due to de novo amplification or represent a secondary resistance mechanism in response targeted therapies. To date, gold standard method evaluate GCN is fluorescence situ hybridization (FISH). However, next-generation sequencing (NGS) becoming more relevant optimize therapy by revealing mutational profile each NSCLC. Using evaluable n = 205 NSCLC...
Ectopic Cushing syndrome is a rare clinical disorder resulting from excessive adrenocorticotrophic hormone (ACTH) produced by non-pituitary neoplasms, mainly neuroendocrine neoplasms (NENs) of the lung, pancreas, and gastrointestinal tract, other less common sites. The genetic background ACTH-producing NENs has not been well studied. Inspired an index case pancreatic NEN carrying gene fusion, we postulated that might be enriched for fusions. We herein examined 21 ACTH-secreting pancreas...
The myeloid C-type lectin receptor (CLR) MINCLE senses the mycobacterial cell wall component trehalose-6,6’-dimycolate (TDM). Recently, we found that IL-4 downregulates expression in macrophages. is a hallmark cytokine helminth infections, which appear to increase risk for infection and active tuberculosis. Here, investigated functional consequences of on MINCLE-driven macrophage activation Th1/Th17 adjuvanticity. inhibited induction after with Mycobacterium bovis bacille Calmette-Guerin...
A subset of exceptionally rare primary renal perivascular epithelioid cell tumours (PEComas) that harbour Xp11.2 translocation have been reported, but no larger series devoted to this topic published.
Abstract Alterations in Homologous Recombination Repair (HRR) Pathway genes have been found to be associated with HR‐Deficiency (HRD), which is an approved biomarker for PARP Inhibitor (PARPi) treatment. The aim of a Molecular Tumor Board (MTB) identify molecular alterations cancer patients advanced tumors that may suggest off‐label treatment options. So far, few studies analyzed the presence HRR gene mutations and their association HRD outside clinical studies. Currently, no data on testing...
The last 2 decades have attended a dynamic evolution in the nosology of poorly differentiated sinonasal tract malignancies, with several new molecularly defined entities having been described addition to delineation genetic driver/s some established older entities. These discoveries, however, mostly concerned epithelial-derived neoplasms (carcinomas). Adamantinoma-like Ewing sarcoma and biphenotypic are major representatives newly mesenchymal categories. colorectal cancer associated (COLCA2)...
(1) Background: molecular tumor boards (MTBs) are crucial instruments for discussing and allocating targeted therapies to suitable cancer patients based on genetic findings. Currently, limited evidence is available regarding the regional impact outreach component of MTBs; (2) Methods: we analyzed MTB patient data from four neighboring Bavarian tertiary care oncology centers in Würzburg, Erlangen, Regensburg, Augsburg, together constituting WERA Alliance. Absolute numbers distribution across...
Although well known as a fusion partner in hematological malignancies, genes involving the ABL proto-oncogene 1 (ABL1), mapping to chromosomal region 9q34.12, have only been anecdotally reported five soft tissue tumors. These neoplasms variously perineurioma, angiofibroma, and solitary fibrous tumor, all harbored GAB1::ABL1 gene fusion; however, nosology clinicopathological characteristics of tumors carrying this rare not delineated. We herein describe eight containing review previously...
Gastrointestinal helminths are a major health threat worldwide. Alternatively activated macrophages (AAMs) have been shown to contribute host protection during secondary helminth infections. AAMs express effector molecules that depend on activation of the IL-4- or IL-13-induced transcription factor signal transducer and activator 6 (STAT6). However, specific role STAT6-regulated genes like Arginase-1 (Arg1) from in other cell types for remains unclear. To address this point, we generated...
Molecular Tumor Boards (MTBs) converge state-of-the-art next-generation sequencing (NGS) methods with the expertise of an interdisciplinary team consisting clinicians, pathologists, human geneticists, and molecular biologists to provide molecularly informed guidance in clinical decision making treating physician. In present study, we particularly focused on elucidating factors impacting translation MTB recommendations, utilizing data generated from gene panel mediated comprehensive genomic...
Highlights•Small cell transformation occurs about 1.5 years after start of targeted therapy•Immunotherapy was associated with a non-significant trend towards longer survival•Efficacy treatment lines platinum/etoposide is limited•The majority tumors acquires DLL3 expression small transformationAbstractIntroductionSmall (SCT) typical mechanism adaptive resistance to third generation epidermal growth factor receptor inhibitors (EGFRi) which have become the standard care for EGFR-driven...
Patients with right-sided metastatic colon carcinoma have a significantly worse prognosis than those left-sided colorectal cancer (CRC), regardless of treatment. The aim the prospective IVOPAK II study was to implement an interdisciplinary guideline-conform personalized CRC palliative therapy and improve overall survival (OS) by multidisciplinary approach via secondary resection. We present efficacy data first-line treatment benefit collaboration patients: n = 25. RAS mutation: 20 (80%):...
Background In precision oncology, the accurate and reproducible classification of variant oncogenicity is fundamental for therapy decision making. 2022, a set guidelines somatic variants in cancer were defined by Clinical Genome Resource, Cancer Genomics Consortium, Variant Interpretation Consortium. However, to date an implementation that automates evaluation these criteria does not exist. Furthermore, majority criteria, interpretation criterion-associated textual indication choice publicly...
ABSTRACT Background Molecular Tumor Boards (MTBs) are crucial instruments for discussing and allocating targeted therapies to suitable cancer patients based on genetic findings. Currently, limited evidence is available regarding the regional impact outreach component of MTBs. Methods We analyzed MTB patient data from four neighboring Bavarian tertiary care oncology centers in Würzburg, Erlangen, Regensburg, Augsburg, together constituting WERA Alliance. Absolute numbers distribution across...
Schlüsselwörter Interdisziplinarität - Medikamentöse Tumortherapie simultan EML-ALK Induktionstherapie interdisciplinarity medical oncology synchronous induction chemotherapy
Abstract The myeloid C-type lectin receptor (CLR) MINCLE senses the mycobacterial cell wall component trehalose-6,6-dimycolate (TDM). Recently, we found that IL-4 down-regulates expression in macrophages. is a hallmark cytokine helminth infections, which appear to increase risk for infection and active tuberculosis. Here, investigated functional consequences of on MINCLE-driven macrophage activation Th1/Th17 adjuvanticity. inhibited induction after with Mycobacterium bovis Bacille...