A5068684049- IL-33, ST2, and ILC Pathways
- Parasites and Host Interactions
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Tuberculosis Research and Epidemiology
- Eosinophilic Esophagitis
- Immune responses and vaccinations
- Asthma and respiratory diseases
- Inflammatory Bowel Disease
- Antifungal resistance and susceptibility
- Eosinophilic Disorders and Syndromes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Invertebrate Immune Response Mechanisms
- Immune Cell Function and Interaction
Universitätsklinikum Erlangen
2022-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2022-2024
The myeloid C-type lectin receptor (CLR) MINCLE senses the mycobacterial cell wall component trehalose-6,6’-dimycolate (TDM). Recently, we found that IL-4 downregulates expression in macrophages. is a hallmark cytokine helminth infections, which appear to increase risk for infection and active tuberculosis. Here, investigated functional consequences of on MINCLE-driven macrophage activation Th1/Th17 adjuvanticity. inhibited induction after with Mycobacterium bovis bacille Calmette-Guerin...
Abstract Eosinophils are potent innate effector cells associated mainly with type 2 immune responses elicited by helminths and allergens. Their activity needs to be tightly controlled prevent severe inflammation tissue damage. Eosinophil degranulation secretion of inflammatory molecules, including cytokines, chemokines, lipid mediators, can regulated activating inhibitory receptors on the cell surface. In this study, we investigated modulation proliferation, apoptosis, gene expression,...
Gastrointestinal helminths are a major health threat worldwide. Alternatively activated macrophages (AAMs) have been shown to contribute host protection during secondary helminth infections. AAMs express effector molecules that depend on activation of the IL-4- or IL-13-induced transcription factor signal transducer and activator 6 (STAT6). However, specific role STAT6-regulated genes like Arginase-1 (Arg1) from in other cell types for remains unclear. To address this point, we generated...
ABSTRACT Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) often associated with a Type 2 immune response. Although previous reports hint at role for signal transducer and activator of transcription (STAT) 6 signaling in non‐immune cells, the contribution STAT6‐activation particularly intestinal epithelial cells (IECs) still unknown. Dextran sodium sulfate (DSS)‐induced model UC mice that we applied here on animals expression constitutively active version STAT6 IECs...
Allergic bronchopulmonary aspergillosis (ABPA) is caused by the fungus Aspergillus fumigatus , afflicts about five million patients globally, and still a noncurable disease. ABPA associated with pronounced lung eosinophilia.