A5038873253- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Head and Neck Cancer Studies
- RNA modifications and cancer
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Colorectal and Anal Carcinomas
- Drug-Induced Hepatotoxicity and Protection
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Neuroendocrine Tumor Research Advances
- Vasculitis and related conditions
- Pharmacological Effects and Toxicity Studies
- Cancer Research and Treatments
- Digestive system and related health
- Advanced Electron Microscopy Techniques and Applications
- Brain Metastases and Treatment
- Cystic Fibrosis Research Advances
- Advanced X-ray and CT Imaging
- Neurological Complications and Syndromes
- Liver Disease and Transplantation
- Cancer-related Molecular Pathways
- Cerebrovascular and Carotid Artery Diseases
- Veterinary medicine and infectious diseases
Ludwig-Maximilians-Universität München
2015-2024
LMU Klinikum
2018-2022
German Cancer Research Center
2022
Heidelberg University
2022
Helmholtz Zentrum München
2018
Abstract Background Peroxisome proliferator-activated receptor gamma (PPARG) is a member of the nuclear family. It involved in regulation adipogenesis, lipid metabolism, insulin sensitivity, vascular homeostasis and inflammation. In addition, PPARG agonists, known as thiazolidinediones, are well established treatment type 2 diabetes mellitus. PPARGs role cancer matter debate, pro- anti-tumour properties have been described various tumour entities. Currently, specific patients with colorectal...
Abstract Purpose: Human papillomavirus (HPV)–negative head and neck squamous cell carcinoma (HNSCC) is associated with unfavorable prognosis, while independent prognostic markers remain to be defined. Experimental Design: We retrospectively performed miRNA expression profiling. Patients were operated for locally advanced HPV-negative HNSCC had received radiochemotherapy in eight different hospitals (DKTK-ROG; n = 85). Selection fulfilled comparable demographic, treatment, follow-up...
Postoperative (chemo) radiation improves tumor control and survival in high-risk patients with head neck squamous cell carcinoma based on established risk factors. The clinical cooperation group “Personalized Radiotherapy Head Neck Cancer” focuses the identification validation of new biomarkers, which are aimed at eventually stratifying personalizing therapy concept. Hence, we reviewed all oral cavity, oropharynx, hypopharynx, or larynx, treated postoperative from 06/2008 until 06/2015...
Previously, we have shown that copy number gain of the chromosomal band 16q24.3 is associated with impaired clinical outcome radiotherapy-treated head and neck squamous cell carcinoma (HNSCC) patients. We set out to identify a prognostic mRNA signature from genes located on in radio(chemo)therapy-treated HNSCC patients TCGA (The Cancer Genome Atlas, n = 99) cohort. applied stepwise forward selection using expression data 41 genes. The resulting optimal Cox-proportional hazards regression...
Brain metastasis (BM) in colorectal cancer (CRC) is a rare event with poor prognosis. Apart from (K)RAS status and lung bone no biomarkers exist to identify patients at risk. This study aimed gene expression signature associated BM.
// Christine Woischke 1, * , Cristina Blaj Eva Marina Schmidt Sebastian Lamprecht 1 Jutta Engel 2 Heiko Hermeking 3, 4 Thomas Kirchner David Horst Pathologisches Institut, Ludwig-Maximilians-Universität München, Germany Tumorregister Institut für medizinische Informationsverarbeitung, Biometrie und Epidemiologie, 3 German Cancer Consortium (DKTK), Heidelberg, Research Center (DKFZ), These authors have contributed equally to this work Correspondence to: Horst, email:...
Abstract Current clinical imaging methods face limitations in the detection and correct characterization of different subtypes renal cell carcinoma (RCC), while these are important for therapy prognosis. The present study evaluates potential grating-based X-ray phase-contrast computed tomography (gbPC-CT) visualization human RCC subtypes. results 23 ex vivo formalin-fixed kidney specimens obtained with CT were compared to absorption-based (gbCT), a 3T MRI validated using histology. Regions...
Abstract We present two rare cases of mixed large cell neuroendocrine carcinoma and squamous the colon. A literature search revealed only three published with similar histology but none these reports provided profound molecular mutational analyses. Our exhibited a distinct, colon‐like immunophenotype strong nuclear CDX2 β ‐catenin expression in more than 90% tumour cells both components. analysed carcinomas regarding microsatellite stability, RAS , BRAF PD‐L1 status. In addition,...
Abstract Hospital‐acquired infections due to multi‐drug resistant Gram‐negative organisms (MDRGNO) pose a major threat global health. A vaccine preventing colonization and consecutive infection with MDRGNO could be particularly valuable, as therapeutic options become increasingly limited. Outer membrane vesicles (OMV) of Escherichia coli strain CFT073 well three strains that had caused severe in humans were administered intranasally mice, without cholera toxin an adjuvant. The humoral immune...
Human papillomavirus (HPV)-driven head and neck squamous cell carcinomas (HNSCC) generally have a more favourable prognosis. We hypothesized that HPV-associated HNSCC may be identified by an miRNA-signature according to their specific molecular pathogenesis, characterized unique transcriptome compared HPV-negative HNSCC. performed miRNA expression profiling of two p16/HPV DNA cohorts patients treated adjuvant radio(chemo)therapy (multicentre DKTK-ROG n = 128, single-centre LMU-KKG 101). A...
Drug-induced liver injury (DILI) is a leading cause of acute failure (ALF). Predictors for orthotopic transplantation (OLT) or death in drug-induced ALF (DI-ALF) are scarce. In total 33 346 patients recruited our prospective study on potentially hepatotoxic drugs had ALF. DILI diagnosis was based Roussel Uclaf Causality Assessment Method (RUCAM) score and expert opinion. Area under the receiver operating characteristic (AUROC) curve, Youden's index positive negative likelihood ratios were...
<p>Supplementary Figures 1-20</p>
<p>Supplementary Figures 1-20</p>
<div>AbstractPurpose:<p>Human papillomavirus (HPV)–negative head and neck squamous cell carcinoma (HNSCC) is associated with unfavorable prognosis, while independent prognostic markers remain to be defined.</p>Experimental Design:<p>We retrospectively performed miRNA expression profiling. Patients were operated for locally advanced HPV-negative HNSCC had received radiochemotherapy in eight different hospitals (DKTK-ROG; <i>n</i> = 85). Selection fulfilled...
<div>AbstractPurpose:<p>Human papillomavirus (HPV)–negative head and neck squamous cell carcinoma (HNSCC) is associated with unfavorable prognosis, while independent prognostic markers remain to be defined.</p>Experimental Design:<p>We retrospectively performed miRNA expression profiling. Patients were operated for locally advanced HPV-negative HNSCC had received radiochemotherapy in eight different hospitals (DKTK-ROG; <i>n</i> = 85). Selection fulfilled...
<p>Supplementary Methods</p>
<p>Supplementary Methods</p>