A5001115451- Advanced X-ray and CT Imaging
- Advanced X-ray Imaging Techniques
- Medical Imaging Techniques and Applications
- Hematopoietic Stem Cell Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Radiation Dose and Imaging
- Lung Cancer Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Acute Lymphoblastic Leukemia research
- Infrared Thermography in Medicine
- Advanced Radiotherapy Techniques
- COVID-19 diagnosis using AI
- Calibration and Measurement Techniques
- Digital Radiography and Breast Imaging
- Neutropenia and Cancer Infections
- Bone health and osteoporosis research
- Cancer Treatment and Pharmacology
- Congenital Diaphragmatic Hernia Studies
- Multiple Myeloma Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Superconducting Materials and Applications
- HIV/AIDS drug development and treatment
- Radiation Therapy and Dosimetry
- Nuclear Physics and Applications
- HIV Research and Treatment
Technical University of Munich
2017-2025
Klinikum rechts der Isar
2020-2025
Cleveland Clinic
2018-2024
European Synchrotron Radiation Facility
2024
University College London
2024
Philips (Germany)
2021-2023
NXP (Netherlands)
2022-2023
Philips (Netherlands)
2022-2023
Institute for Advanced Study
2023
Karlsruhe Institute of Technology
2022
Although advanced medical imaging technologies give detailed diagnostic information, a low-dose, fast, and inexpensive option for early detection of respiratory diseases follow-ups is still lacking. The novel method x-ray dark-field chest might fill this gap but has not yet been studied in living humans. Enabling the assessment microstructural changes lung parenchyma, technique presents more sensitive alternative to conventional x-rays, requires only fraction dose applied CT. We application...
Background X-ray dark-field radiography takes advantage of the wave properties x-rays, with a relatively high signal in lungs due to many air-tissue interfaces alveoli. Purpose To describe qualitative and quantitative characteristics x-ray images healthy human subjects. Materials Methods Between October 2018 January 2020, patients legal age who underwent chest CT as part their diagnostic work-up were screened for study participation. Inclusion criteria normal scan, ability consent, stand...
Background Dark-field chest radiography allows for assessment of lung alveolar structure by exploiting wave optical properties x-rays. Purpose To evaluate the qualitative and quantitative features dark-field in participants with pulmonary emphysema as compared those healthy control subjects. Materials Methods In this prospective study conducted from October 2018 to 2020, aged at least 18 years who underwent clinically indicated CT were screened participation. Inclusion criteria an ability...
Dark-field chest radiography allows the assessment of structural integrity alveoli by exploiting wave properties x-rays. To compare qualitative and quantitative features dark-field in patients with COVID-19 pneumonia conventional CT imaging. In this prospective study conducted from May 2020 to December 2020, aged at least 18 years who underwent for clinically suspected infection were screened participation. Inclusion criteria a CO-RADS score ≥4, ability consent procedure stand upright...
Abstract Background Dark-field chest radiography is sensitive to the lung alveolar structure. We evaluated change of dark-field signal between inspiration and expiration. Methods From 2018 2020, patients who underwent computed tomography (CT) were prospectively enrolled, excluding those with any condition besides emphysema visible on CT. Participants imaged in both expiration a prototype system. calculated total ∑DF coefficient ϵ , assumed be proportional number alveoli density,...
Abstract Background Currently, alternative medical imaging methods for the assessment of pulmonary involvement in patients infected with COVID-19 are sought that combine a higher sensitivity than conventional (attenuation-based) chest radiography lower radiation dose CT imaging. Methods Sixty COVID-19-associated lung changes scan and 40 subjects without pathologic visible were included (in total, 100, 59 male, mean age 58 ± 14 years). All gave written informed consent. We employed clinical...
Abstract Objectives Dark-field chest radiography (dfCXR) has recently reached clinical trials. Here we compare dfCXR to conventional for the detection and staging of pulmonary emphysema. Materials Methods Subjects were included after a medically indicated computed tomography (CT) scan, showing either no lung impairments or different stages To establish ground truth, all CT scans assessed by 3 radiologists assigning emphysema severity scores based on Fleischner Society classification scheme....
The purpose of this study was to evaluate the dose characteristic for patient examinations at first clinical X-ray dark-field chest radiography system and determine whether effective is within a clinically acceptable range.A setup grating-based constructed commissioned, operating tube voltage 70 kVp. Thermoluminescent dosimeter (TLD) measurements were conducted using an anthropomorphic phantom modeling reference person obtain conversion coefficient relating area product (DAP) system. For 92...
Dark-field radiography, a new X-ray imaging method, has recently been applied to human chest for the first time. It employs conventional devices in combination with Talbot-Lau interferometer large field of view, providing both attenuation and dark-field radiographs. is well known that sample scatter creates artifacts modalities. Here, we demonstrate also generated by as detector crosstalk create radiographs, addition expected loss spatial resolution. We propose deconvolution-based correction...
Background: Dark-field imaging is a novel modality that allows for the assessment of material interfaces by exploiting wave character x-ray. While it has been extensively studied in chest imaging, only little known about other tissues. Therefore, purpose this study was to evaluate whether clinical X-ray dark-field scanner prototype osteoporosis. Materials and methods: In prospective we examined human cadaveric lumbar spine specimens (vertebral segments L2 L4). We used radiography yields both...
Dark-field radiography of the human chest is a promising novel imaging technique with potential becoming valuable tool for early diagnosis chronic obstructive pulmonary disease and other diseases lung. The large field-of-view needed clinical purposes could recently be achieved by scanning system. While this approach overcomes limited availability area grating structures, it also results in prolonged image acquisition time, leading to concomitant motion artifacts caused intrathoracic...
X-ray dark-field imaging enables a spatially-resolved visualization of ultra-small-angle scattering. Using phantom measurements, we demonstrate that material's effective signal may be reduced by modification the visibility spectrum other dark-field-active objects in beam. This is equivalent conventional beam-hardening, and distinct from related, known effects, where modified attenuation or phase shifts. We present theoretical model for this group effects verify it comparison to measurements....
To compare the visibility of anatomical structures and overall quality attenuation images obtained with a dark-field X-ray radiography prototype those from commercial system.Each 65 patients recruited for this study thorax radiograph at reference system. Five radiologists independently assessed structures, level motion artifacts, image all on five-point scale, 5 points being highest rating. The average scores were compared between two types. differences evaluated using an area under curve...
Grating-based X-ray phase-contrast and in particular dark-field radiography are promising new imaging modalities for medical applications. Currently, the potential advantage of early-stage diagnosis pulmonary diseases humans is being investigated. These studies make use a comparatively large scanning interferometer at short acquisition times, which comes expense significantly reduced mechanical stability as compared to tabletop laboratory setups. Vibrations create random fluctuations grating...
Supplemental material is available for this article.
Febrile neutropenia (FN) is an oncologic emergency frequently encountered in hematopoietic cell transplant (HCT) and chimeric antigen receptor (CAR) T-cell therapy patients, which requires immediate initiation of broad-spectrum antibiotics. Data regarding antibiotic de-escalation (DE) neutropenic patients are limited, guideline recommendations vary. A clinical protocol for DE agents was implemented if were afebrile after 72 hours had no evidence infection. The primary endpoint the difference...
"Imaging Three-Dimensional Airway Morphology in Congenital Pulmonary Malformation Using Hierarchical Phase Contrast Tomography." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
Optimal administration of busulfan (Bu) is hampered by variable and unpredictable drug metabolism in individual patients. At our institution, Bu was previously administered with fixed weight-based dosing (WBD) combination cyclophosphamide (Cy) etoposide (E) for patients non-Hodgkin lymphoma (NHL) undergoing autologous stem cell transplantation (ASCT). In 2014, we adopted real-time pharmacokinetic (PK)-guided therapeutic monitoring (TDM) all NHL Bu-containing ASCT. Here compare outcomes who...
Abstract Background Spirometry and conventional chest x-ray have limitations in investigating early emphysema, while computed tomography, the reference imaging method this context, is not part of routine patient care due to its higher radiation dose. In work, we investigated a novel low-dose modality, dark-field x-ray, for evaluation emphysema patients with alpha1-antitrypsin deficiency. Methods By exploiting wave properties x-rays contrast formation, visualises structural integrity alveoli,...
Summary Background Diseases of the respiratory system are leading global causes chronic morbidity and mortality. While advanced medical imaging technologies today deliver detailed diagnostic information, a low-dose, fast, inexpensive option for early detection and/or follow-ups is still lacking. Here, we report on first human application novel modality, namely X-ray dark-field chest imaging, which might fill this gap. Enabling assessment microstructural changes in lung parenchyma, technique...
Zielsetzung Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of death worldwide, yet early detection and treatment can prevent the progression disease. X-ray Computed Tomography (CT) scans chest provide quantitative measure morphological changes in lung. The potential incorporating optimal Window Setting (WS) selection, typically carried out during examination CT for COPD, generally overlooked deep learning models. We aim to optimize COPD with densely connected convolutional...