A5102821046- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Meningioma and schwannoma management
- Radiation Dose and Imaging
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Esophageal Cancer Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Radiation Therapy and Dosimetry
- Colorectal and Anal Carcinomas
- Advanced X-ray and CT Imaging
- Advances in Oncology and Radiotherapy
- Breast Lesions and Carcinomas
- Radiopharmaceutical Chemistry and Applications
- Colorectal Cancer Surgical Treatments
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Cancer, Hypoxia, and Metabolism
Klinikum rechts der Isar
2014-2024
Technical University of Munich
2013-2024
Klinik und Poliklinik für Strahlentherapie und Radioonkologie
2009-2020
München Klinik
2014-2020
Ottawa Hospital
2019
Ospedale di Parma
2018
Deutschen Konsortium für Translationale Krebsforschung
2017
Universitätsklinik für Stereotaktische Neurochirurgie
2017
Fundación Instituto Valenciano de Oncología
2016
University of Würzburg
2007-2015
Adaptive Radiotherapy aims to identify anatomical deviations during a radiotherapy course and modify the treatment plan maintain objectives. This requires regions of interest (ROIs) be defined using most recent imaging data. study investigates clinical utility deformable image registration (DIR) automatically propagate ROIs. Target (GTV) organ-at-risk (OAR) ROIs were non-rigidly propagated from planning CT scan per-treatment for 22 patients. Propagated quantitatively compared with expert...
The impact of local tumor ablative therapy in oligometastasized prostate cancer (PC) is still under debate. To gain data for this approach, we evaluated PC patients receiving stereotactic body radiotherapy (SBRT) to bone metastases.In retrospective study, 15 with a total 20 metastases were regarding biochemical progression-free survival (PSA-PFS), time initiation ADT, and control rate (LCR). Three received concomitant androgen deprivation (ADT).The median follow-up after RT was 22.5 months...
Abstract Background Throughout the last years, carbon‐fibre‐reinforced PEEK (CFP) pedicle screw systems were introduced to replace standard titanium alloy (Ti) implants for spinal instrumentation, promising improved radiotherapy (RT) treatment planning accuracy. We compared dosimetric impact of both intensity modulated proton (IMPT) and volumetric arc photon therapy (VMAT), with focus on uncertainties in Hounsfield unit assignment alloy. Methods Retrospective was performed CT data five...
This study was performed to evaluate skin toxicity during modern three-dimensional conformal radiotherapy (3D-CRT) and the importance of dose distribution patient related factors.This comprises 255 patients with breast cancer treated tangential after conserving surgery between 03/2012 05/2017. The median prescribed 50.4 Gy (range 50-50.4) 92.2% received a sequential boost 10-16 Gy. Adverse toxicities (according CTCAE v. 4.03 occurrence moist desquamations) were assessed at end treatment. in...
The aim of this study was to compare dose-volume histogram (DVH) with dose-mass (DMH) parameters for treatment left-sided breast cancer in deep inspiration breath-hold (DIBH) and free breathing (FB). Additionally, lung expansion anatomical factors were analyzed correlated dose differences.For 31 patients 3D conformal radiation therapy plans retrospectively calculated on FB DIBH CTs the planning system. doses, structures CT data transferred into MATLAB DVHs DMHs calculated. Mean doses...
The aim of the present study was to evaluate if it is feasible for experienced radiation oncologists visually sort out patients with a large dose heart. This would facilitate retrospective data evaluations. And in case an insufficient visual assessment, define which structures should be contoured and can skipped as their derived from other easily future clinical trials.Planning CTs left-sided breast cancer treated 3D-conformal radiotherapy by tangential fields were divided into two groups:...
X-ray and particle radiation therapy planning requires accurate estimation of local electron density within the patient body to calculate dose delivery tumour regions. We evaluate feasibility accuracy measurement using dual-layer computed tomography (DLCT), a recently introduced dual-energy CT technique.Two calibration phantoms were scanned with DLCT virtual monoenergetic images (VMIs) at 50 keV 200 generated. investigated two approaches obtain relative densities from these VMIs: fit an...
Oncoplastic surgery techniques lead to a rearrangement of the breast tissue and impede target definition during adjuvant radiotherapy (RT). The aim this study was assess local control rates after immediate oncoplastic RT.This comprises 965 patients who underwent breast-conserving therapy RT between 01/2000 12/2005. 288 received (ONC) 677 only (NONC). All were treated with external tangential-beam (total dose: 50/50.4 Gy; fraction dose 1.8/2.0 Gy). An additional boost 10-16 Gy primary tumor...
Maximum (MIP) and average intensity projection (AIP) CTs allow rapid definition of internal target volumes in a 4D-CT. The purpose this study was to assess the accuracy these techniques large patient cohort combination with simulations on lung phantom.4DCT data from self-developed 3D phantom 50 patients tumors were analyzed. ITVs contoured maximum (ITVMIP) (ITVAIP) subsequently compared 10 phases 4D-CT (ITV10). In additionally theoretical volume calculated for each motion volumes.ITV10...
Purpose: In radiotherapy (RT) of brain tumors, the primary motor cortex is not regularly considered in target volume delineation, although decline function possible due to radiation. Non-invasive identification motor-eloquent areas currently mostly restricted functional magnetic resonance imaging (fMRI), which has shown lack precision for this purpose. Navigated transcranial stimulation (nTMS) a novel tool identify areas. This study aims integrate nTMS maps RT planning and evaluates...
To investigate dynamic contrast-enhanced MRI (DCE-MRI) for quantification of pulmonary blood flow (PBF) and volume (PBV) using the prebolus approach to compare results global lung perfusion (GLP).Eleven volunteers were examined by applying different contrast agent doses (0.5, 1.0, 2.0, 3.0 mL gadolinium diethylene triamine pentaacetic acid [Gd-DTPA]), a saturation-recovery (SR) true fast imaging with steady precession (TrueFISP) sequence. PBF PBV determined single bolus prebolus. Region...
Tumor-Treating Fields (TTFields) are a novel treatment strategy for glioblastoma (GBM) that is approved the use concomitantly to adjuvant chemotherapy. Preclinical data suggest synergistic interaction of TTFields and radiotherapy (RT). However, dosimetric uncertainties caused by highly dense arrays have led caution applying TTF setup during RT.