Purpose Accelerated repopulation is a main reason for locoregional failure after fractionated radiotherapy head and neck squamous cell carcinoma (HNSCC). Epidermal growth factor receptor (EGFR) key controller of cellular proliferation in HNSCC, which stimulated the current study to look direct link between EGFR status possible clinical advantage accelerated radiotherapy. Patients Methods Immunohistochemical staining was performed 304 patients with available pretreatment tumor biopsy material...

Other investigators have demonstrated by transfer of medium from irradiated cells and irradiation with low-fluence alpha particles or microbeams that do not to be directly exposed ionizing radiation detrimentally affected, i.e. bystander effects. In this study, we demonstrate X-irradiated human CGL1 hybrid the killing reduces plating efficiency nonirradiated 33 +/- 6%. addition, show amount cell death induced effects is dependent on X-ray dose, induction apoptosis does appear responsible for...

A report is given on the controversial subject of vertebral retroposition. The following findings were obtained:— Vertebral retroposition does occur. It mainly in lumbosacral spine, but can occur upper lumbar, dorsal, or cervical region. There generally present a definite reduction intervertebral space (84·4 per cent.), either due to disc protrusion, osteoarthritic degeneration, infection, trauma. few cases are congenital origin. not cause radiating backache, radiological indication changes.

The US nuclear weapons testing program in the Pacific conducted between 1946 and 1958 resulted radiation exposure Marshall Islands. potentially widespread from radioiodines of fallout has raised concerns about risk thyroid cancer Marshallese population. most serious exposures its health hazards hydrogen-thermonuclear bomb test, Castle BRAVO, on March 1, 1954. Between 1993 1997, we screened 3, 709 for disease who were born before BRAVO test. It was 60% entire population at still alive time...

Journal Article Gamma ray-induced bystander effect in tumour glioblastoma cells: a specific study on cell survival, cytokine release and receptors Get access A. Facoetti, Facoetti *Corresponding author: facoetti@unipv.it Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Ballarini, Ballarini R. Cherubini, Cherubini S. Gerardi, Gerardi Nano, Nano Ottolenghi, Ottolenghi K. M. Prise, Prise Trott, Trott C. Zilio Radiation Protection Dosimetry, Volume 122, Issue...

The aim of the present study was to evaluate if it is feasible for experienced radiation oncologists visually sort out patients with a large dose heart. This would facilitate retrospective data evaluations. And in case an insufficient visual assessment, define which structures should be contoured and can skipped as their derived from other easily future clinical trials.Planning CTs left-sided breast cancer treated 3D-conformal radiotherapy by tangential fields were divided into two groups:...

SummaryRadiation-induced myocardial degeneration in the rat is preceded by changes capillary structure and function, which may be a major factor pathogenesis of radiation-induced heart disease. In order to investigate mechanism damage we studied endothelial cell proliferation untreated control rats at different times following local irradiation with 20 Gy using [3H]thymidine autoradiography. Since latency as well are about twice long Sprague-Dawley Wistar rats, was both strains. The...

SummaryThe clonogenic potential of the progeny irradiated cells was tested in vitro by replating cultures after various times, allowing between five and over 25 subsequent divisions to take place irradiation. Whereas plating efficiency surviving Chinese hamster not decreased, C3H10T½ a dose-dependent but slight decrease observed even longest follow-up period. These data do contradict prevalent hypothesis radiobiology that proliferation colonogenic cell irradiation is significantly different...

In 1963, before Ellis (1971) introduced the NSD concept, we started a clinical study on four different fractionation schedules in patients with cancer of skin, irradiated X rays, to check validity Strandqvist line within and beyond overall time limits his observations. The postirradiation reactions results were compared reaction skin lesions treated our standard schedule 50–51 Gy 17 fractions 23 days. first step was establish iso-effective single dose. We 22 Gy. after this dose definitely...

Abstract Purpose: Most radioimmunotherapy studies on radiolabeled antibody distribution are based autoradiographic and radioluminographic data, which provide a lack of detailed information due to low resolution. We used fluorescently labeled anti–carcinoembryonic antigen (CEA) (A5B7) investigate quantitatively the kinetics microdistribution in clinically relevant orthotopic colorectal cancer model (LS174T) using high-resolution digital microscopy. Experimental Design: Nude mice bearing...

The usual method for estimating the risk from exposure to neutrons uses concept of relative biological effectiveness (RBE) compared with photons, which is better known. RBE has been evaluated using cellular and animal models. But this causes difficulties in applying humans. ANDANTE project takes a new approach three different disciplines parallel: Physics: track structure model used contrast patterns damage macro-molecules photons. simulations reproduce same energy spectra as are other two...