A5054359721- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Ischemic Stroke Management
- Meningioma and schwannoma management
- Moyamoya disease diagnosis and treatment
- Radiation Dose and Imaging
- Venous Thromboembolism Diagnosis and Management
- Advanced X-ray and CT Imaging
- Cerebrospinal fluid and hydrocephalus
- Stroke Rehabilitation and Recovery
- Advanced MRI Techniques and Applications
- Neurosurgical Procedures and Complications
- Spinal Fractures and Fixation Techniques
- Orthopedic Surgery and Rehabilitation
- Glioma Diagnosis and Treatment
- Artificial Intelligence in Healthcare and Education
- Medical Imaging Techniques and Applications
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Arrhythmias and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Peripheral Artery Disease Management
- Blood Coagulation and Thrombosis Mechanisms
University Hospital Cologne
2018-2025
University of Cologne
2017-2025
General Department of Preventive Medicine
2024
Centrum für Integrierte Onkologie
2022
Klinik und Poliklinik für Psychosomatik und Psychotherapie
2020
University Hospital Heidelberg
2015-2016
Heidelberg University
2015-2016
University Medical Centre Mannheim
2015
Brigham and Women's Hospital
2015
University of Massachusetts Lowell
2015
Background Intrasaccular flow disruption represents a new paradigm in endovascular treatment of wide-necked bifurcation aneurysms. Objective To perform matched case–control study comparing complications and angiographic outcome using the Woven Endobridge (WEB) device stent-assisted coiling (SAC). Methods Sixty-six patients treated with WEB at three German tertiary care centers were included 66 SAC based on aneurysm location unruptured/ruptured status. Parameters retrospectively analysed...
Abstract In aneurysmal subarachnoid hemorrhage (aSAH), accurate diagnosis of aneurysm is essential for subsequent treatment to prevent rebleeding. However, detection proves be challenging and time-consuming. The purpose this study was develop evaluate a deep learning model (DLM) automatically detect segment aneurysms in patients with aSAH on computed tomography angiography. retrospective single-center study, three different DLMs were trained 68 79 treated (2016–2017) using...
Malignant melanoma is an aggressive skin cancer in which brain metastases are common. Our aim was to establish and evaluate a deep learning model for fully automated detection segmentation of patients with malignant using clinical routine MR imaging.Sixty-nine total 135 at initial diagnosis available multiparametric imaging datasets (T1-/T2-weighted, T1-weighted gadolinium contrast-enhanced, FLAIR) were included. A previously established architecture (3D convolutional neural network;...
Non-small cell lung cancer (NSCLC) is the most common tumor entity spreading to brain and up 50% of patients develop metastases (BMs). Detection BMs on MRI challenging with an inherent risk missed diagnosis.To train evaluate a deep learning model (DLM) for fully automated detection 3D segmentation in NSCLC clinical routine MRI.Retrospective.Ninety-eight 315 pretreatment MRI, divided into training (66 patients, 248 BMs) independent test (17 67 control (15 0 cohorts.T1 -/T2 -weighted, T1...
The flow re-direction endoluminal device (FRED) is a safe and effective treatment option for intracranial aneurysms. novel FRED X features an antithrombotic surface coating ("X Technology") on otherwise unmodified stent design. This two-center study evaluates the clinical safety efficacy of compares it to literature.
Diagnosing myocarditis relies on multimodal data, including cardiovascular magnetic resonance (CMR), clinical symptoms, and blood values. The correct interpretation integration of CMR findings require radiological expertise knowledge. We aimed to investigate the performance Generative Pre-trained Transformer 4 (GPT-4), a large language model, for report-based medical decision-making in context cardiac MRI suspected myocarditis.
Background The latest advancement of artificial intelligence (AI) is generative pretrained transformer large language models (LLMs). They have been trained on massive amounts text, enabling humanlike and semantical responses to text-based inputs requests. Foreshadowing numerous possible applications in various fields, the potential such tools for medical data integration clinical decision-making not yet clear. Objective In this study, we investigate LLMs report-based example acute ischemic...
Abstract Background We evaluated the acceleration of a three-dimensional isotropic flow-independent magnetic resonance angiography (MRA) (relaxation-enhanced without contrast and triggering, REACT) neck arteries using compressed SENSE (CS) combined with deep learning (adaptive intelligence, AI)-based reconstruction (CS-AI). Methods Thirty-four volunteers received 3-T REACT MRA, acquired threefold: (i) CS factor 7 (CS7), scan time 1:20 min:s; (ii) 10 (CS10), 0:55 (iii) CS-AI (CS10-AI), min:s....
Phenox flow diverters (p64 and its smaller vessel variant p48) represent an established treatment option for intracranial aneurysms. This study evaluates the safety efficacy of new generation these devices with additional antithrombotic surface coating (HPC). Consecutive patients treated between 2020 2023 at three institutions were retrospectively reviewed aneurysm characteristics, procedural details, complications, angiographic outcomes. Sixty-one (mean age 56 years) 61 The mean size was...
Background The Woven EndoBridge (WEB) device is a novel endovascular tool for the treatment of wide-necked intracranial aneurysms. Objective To evaluate factors influencing aneurysm occlusion and recurrence after WEB embolization. Methods A total 113 patients (mean age 58.9±11.9 years) with 114 aneurysms size 8.6±4.6 mm) were successfully treated at three German tertiary care centers between May 2011 February 2018. Aneurysm was evaluated using Raymond-Roy classification. We retrospectively...
Von Willebrand factor (VWF) serves as a nidus for platelet aggregation and thrombosis. We hypothesize that VWF fibers contribute to the development of venous thromboembolism (VTE) metastasis formation. Here, we show vascular lymphatic endothelial cells (ECs) express in vitro release after activation by tumor cell supernatants. In contrast, an ex vivo analysis primary mouse tumors revealed presence blood microvasculature but not vessels. Unlike anticoagulant Fondaparinux, inhibitor thrombin...
Background The Derivo Embolization Device (DED) is a novel flow diverter stent that provides increased x-ray visibility, an improved delivery system, and potentially reduced thrombogenicity. objective of this study was to evaluate the early safety efficacy second-generation DED. Methods We retrospectively analyzed all patients with unruptured intracranial aneurysms (UIAs) treated DED between November 2015 December 2017 in three German tertiary care centers. Procedural details, complications,...
Background The Derivo Embolization Device (DED) is a novel flow diverter with advanced X-ray visibility, potentially lower thrombogenicity, and an improved delivery system. Objective To evaluate the safety efficacy of DED for emergency treatment ruptured intracranial aneurysms. Methods Between February 2016 March 2018, 10 patients (median age 54.5 years, seven women) 11 aneurysms were treated at three neurovascular centers. Procedural details, complications, morbidity, aneurysm occlusion...
Background Woven Endobridge (WEB) embolization is a safe and efficient technique for endovascular treatment of intracranial aneurysms. However, the management aneurysm recurrence after WEB placement has not been well described to date. We present our multicenter experience retreatment implantation. Methods This study patients who underwent implantation in three German tertiary care centers. Treatment strategies, complications, angiographic outcome were retrospectively assessed. Results Among...
In stroke magnetic resonance imaging (MRI), contrast-enhanced angiography (CE-MRA) is the clinical standard to depict extracranial arteries but native MRA techniques are of increased interest facilitate practice. The purpose this study was assess detection internal carotid artery (ICA) stenosis and plaques as well image quality cervical between a novel flow-independent relaxation-enhanced without contrast triggering (REACT) sequence CE-MRA in acute ischemic (AIS).In retrospective,...
Abstract The use of mobile head CT scanners in the neurointensive care unit (NICU) saves time for patients and NICU staff can reduce transport-related mishaps, but reduced image quality previous has prevented their widespread clinical use. This study compares SOMATOM On.Site (Siemens Healthineers, Erlangen, Germany), a state-of-the-art scanner, conventional 64-slice stationary scanner. included 40 who underwent scans with both scanners. Gray white matter signal noise were measured at...